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Volumn 393, Issue 12, 2012, Pages 1391-1403

Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon

Author keywords

Colon; Cysteine cathepsins; Intercellular junctions; Intestinal barrier; Mucus

Indexed keywords

CATHEPSIN B; CATHEPSIN K; CATHEPSIN L; CATHEPSIN X; CLAUDIN 1; COLLAGEN TYPE 4; COLLAGENASE; ELASTASE; LAMININ; MUCIN 2; OCCLUDIN; UVOMORULIN;

EID: 84869404265     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2012-0204     Document Type: Conference Paper
Times cited : (14)

References (53)
  • 1
    • 80053623241 scopus 로고    scopus 로고
    • Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP
    • Arampatzidou, M., Mayer, K., Lolyeva, M.E., Asrat, S.G., Ravichandran, M., Gunther, T., Schule, R., Reinheckel, T., and Brix, K. (2011a). Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP. Biol. Chem. 392, 983-993.
    • (2011) Biol. Chem. , vol.392 , pp. 983-993
    • Arampatzidou, M.1    Mayer, K.2    Lolyeva, M.E.3    Asrat, S.G.4    Ravichandran, M.5    Gunther, T.6    Schule, R.7    Reinheckel, T.8    Brix, K.9
  • 2
    • 84860389887 scopus 로고    scopus 로고
    • Imaging of protease functions-Current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues
    • Arampatzidou, M., Rehders, M., Dauth, S., Yu, D.M., Tedelind, S., and Brix, K. (2011b). Imaging of protease functions-current guide to spotting cysteine cathepsins in classical and novel scenes of action in mammalian epithelial cells and tissues. Ital. J. Anat. Embryol. 116, 1-19.
    • (2011) Ital. J. Anat. Embryol. , vol.116 , pp. 1-19
    • Arampatzidou, M.1    Rehders, M.2    Dauth, S.3    Yu, D.M.4    Tedelind, S.5    Brix, K.6
  • 5
    • 38649111363 scopus 로고    scopus 로고
    • Cysteine cathepsins: Cellular roadmap to different functions
    • Brix, K., Dunkhorst, A., Mayer, K., and Jordans, S. (2008). Cysteine cathepsins: cellular roadmap to different functions. Biochimie 90, 194-207.
    • (2008) Biochimie , vol.90 , pp. 194-207
    • Brix, K.1    Dunkhorst, A.2    Mayer, K.3    Jordans, S.4
  • 6
    • 79960071578 scopus 로고    scopus 로고
    • Cysteine cathepsins and the skeleton
    • Bromme, D. (2011). Cysteine cathepsins and the skeleton. Clin. Rev. Bone Miner. Metab. 9, 83-93.
    • (2011) Clin. Rev. Bone Miner. Metab. , vol.9 , pp. 83-93
    • Bromme, D.1
  • 7
    • 0029310512 scopus 로고
    • Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution
    • Bromme, D. and Okamoto, K. (1995). Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution. Biol. Chem. Hoppe Seyler 376, 379-384.
    • (1995) Biol. Chem. Hoppe Seyler , vol.376 , pp. 379-384
    • Bromme, D.1    Okamoto, K.2
  • 9
    • 79960666941 scopus 로고    scopus 로고
    • Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits
    • Dauth, S., Sirbulescu, R.F., Jordans, S., Rehders, M., Avena, L., Oswald, J., Lerchl, A., Saftig, P., and Brix, K. (2011b). Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits. BMC Neurosci. 12, 74.
    • (2011) BMC Neurosci. , vol.12 , pp. 74
    • Dauth, S.1    Sirbulescu, R.F.2    Jordans, S.3    Rehders, M.4    Avena, L.5    Oswald, J.6    Lerchl, A.7    Saftig, P.8    Brix, K.9
  • 10
    • 33645051476 scopus 로고    scopus 로고
    • Design of cathepsin K inhibitors for osteoporosis
    • Deaton, D.N. and Tavares, F.X. (2005). Design of cathepsin K inhibitors for osteoporosis. Curr. Top. Med. Chem. 5, 1639-1675.
    • (2005) Curr. Top. Med. Chem. , vol.5 , pp. 1639-1675
    • Deaton, D.N.1    Tavares, F.X.2
  • 12
    • 70349471029 scopus 로고    scopus 로고
    • Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: A comparison of available tools
    • Desmarais, S., Masse, F., and Percival, M.D. (2009). Pharmacological inhibitors to identify roles of cathepsin K in cell-based studies: a comparison of available tools. Biol. Chem. 390, 941-948.
    • (2009) Biol. Chem. , vol.390 , pp. 941-948
    • Desmarais, S.1    Masse, F.2    Percival, M.D.3
  • 16
    • 0029809357 scopus 로고    scopus 로고
    • Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
    • Gelb, B.D., Shi, G.P., Chapman, H.A., and Desnick, R.J. (1996). Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science 273, 1236-1238.
    • (1996) Science , vol.273 , pp. 1236-1238
    • Gelb, B.D.1    Shi, G.P.2    Chapman, H.A.3    Desnick, R.J.4
  • 17
    • 0029055417 scopus 로고
    • Colonic epithelium is diffusely abnormal in ulcerative colitis and colorectal cancer
    • Gibson, P., Rosella, O., Nov, R., and Young, G. (1995). Colonic epithelium is diffusely abnormal in ulcerative colitis and colorectal cancer. Gut 36, 857-863.
    • (1995) Gut , vol.36 , pp. 857-863
    • Gibson, P.1    Rosella, O.2    Nov, R.3    Young, G.4
  • 19
    • 84856703493 scopus 로고    scopus 로고
    • An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants
    • Gustafsson, J.K., Ermund, A., Johansson, M.E., Schutte, A., Hansson, G.C., and Sjovall, H. (2011). An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants. Am. J. Physiol. Gastrointest. Liver Physiol. 302, G430-G438.
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.302
    • Gustafsson, J.K.1    Ermund, A.2    Johansson, M.E.3    Schutte, A.4    Hansson, G.C.5    Sjovall, H.6
  • 21
    • 0030091627 scopus 로고    scopus 로고
    • Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract
    • Hanby, A.M., Chinery, R., Poulsom, R., Playford, R.J., and Pignatelli, M. (1996). Downregulation of E-cadherin in the reparative epithelium of the human gastrointestinal tract. Am. J. Pathol. 148, 723-729.
    • (1996) Am. J. Pathol. , vol.148 , pp. 723-729
    • Hanby, A.M.1    Chinery, R.2    Poulsom, R.3    Playford, R.J.4    Pignatelli, M.5
  • 22
    • 0027533464 scopus 로고
    • Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells
    • Howell, S., Brewis, I.A., Hooper, N.M., Kenny, A.J., and Turner, A.J. (1993). Mosaic expression of membrane peptidases by confluent cultures of Caco-2 cells. FEBS Lett. 317, 109-112.
    • (1993) Febs Lett. , vol.317 , pp. 109-112
    • Howell, S.1    Brewis, I.A.2    Hooper, N.M.3    Kenny, A.J.4    Turner, A.J.5
  • 25
    • 79952748335 scopus 로고    scopus 로고
    • The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    • Johansson, M.E., Larsson, J.M., and Hansson, G.C. (2011b). The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc. Natl. Acad. Sci. USA 108 (Suppl 1), 4659-4665.
    • (2011) Proc. Natl. Acad. Sci. , vol.108 , Issue.1 , pp. 4659-4665
    • Johansson, M.E.1    Larsson, J.M.2    Hansson, G.C.3
  • 26
    • 71049188177 scopus 로고    scopus 로고
    • Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions
    • Jordans, S., Jenko-Kokalj, S., Kuhl, N.M., Tedelind, S., Sendt, W., Bromme, D., Turk, D., and Brix, K. (2009). Monitoring compartment-specific substrate cleavage by cathepsins B, K, L, and S at physiological pH and redox conditions. BMC Biochem. 10, 23.
    • (2009) BMC Biochem. , vol.10 , pp. 23
    • Jordans, S.1    Jenko-Kokalj, S.2    Kuhl, N.M.3    Tedelind, S.4    Sendt, W.5    Bromme, D.6    Turk, D.7    Brix, K.8
  • 28
    • 71249111374 scopus 로고    scopus 로고
    • Odanacatib, a cathepsin K inhibitor for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling
    • Lewiecki, E.M. (2009). Odanacatib, a cathepsin K inhibitor for the treatment of osteoporosis and other skeletal disorders associated with excessive bone remodeling. IDrugs 12, 799-809.
    • (2009) IDrugs , vol.12 , pp. 799-809
    • Lewiecki, E.M.1
  • 29
    • 33745121509 scopus 로고    scopus 로고
    • Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel
    • Lidell, M.E., Moncada, D.M., Chadee, K., and Hansson, G.C. (2006). Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel. Proc. Natl. Acad. Sci. USA 103, 9298-9303.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 9298-9303
    • Lidell, M.E.1    Moncada, D.M.2    Chadee, K.3    Hansson, G.C.4
  • 31
    • 50249105789 scopus 로고    scopus 로고
    • Laminin α5 influences the architecture of the mouse small intestine mucosa
    • Mahoney, Z.X., Stappenbeck, T.S., and Miner, J.H. (2008). Laminin α5 influences the architecture of the mouse small intestine mucosa. J. Cell Sci. 121, 2493-2502.
    • (2008) J. Cell Sci. , vol.121 , pp. 2493-2502
    • Mahoney, Z.X.1    Stappenbeck, T.S.2    Miner, J.H.3
  • 32
    • 38649115273 scopus 로고    scopus 로고
    • Extracellular localization of intestinal cathepsins: Implications of their actions during post-operative ileus
    • B. Vollmar, ed. (Rostock, Germany: Medimond International Proceedings
    • Mayer, K., Schwartz, S., Lentze, M.J., Kalff, J.C., and Brix, K. (2006). Extracellular localization of intestinal cathepsins: implications of their actions during post-operative ileus. In: XLI Congress of the European Society for Surgical Research, B. Vollmar, ed. (Rostock, Germany: Medimond International Proceedings), pp. 63-66.
    • (2006) XLI Congress of the European Society for Surgical Research , pp. 63-66
    • Mayer, K.1    Schwartz, S.2    Lentze, M.J.3    Kalff, J.C.4    Brix, K.5
  • 33
    • 67649620040 scopus 로고    scopus 로고
    • Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation
    • Mayer, K., Vreemann, A., Qu, H., and Brix, K. (2009). Release of endo-lysosomal cathepsins B, D, and L from IEC6 cells in a cell culture model mimicking intestinal manipulation. Biol. Chem. 390, 471-480.
    • (2009) Biol. Chem. , vol.390 , pp. 471-480
    • Mayer, K.1    Vreemann, A.2    Qu, H.3    Brix, K.4
  • 34
    • 33747626518 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in intestinal inflammation
    • Medina, C. and Radomski, M.W. (2006). Role of matrix metalloproteinases in intestinal inflammation. J. Pharmacol. Exp. Ther. 318, 933-938.
    • (2006) J. Pharmacol. Exp. Ther. , vol.318 , pp. 933-938
    • Medina, C.1    Radomski, M.W.2
  • 36
    • 48149111676 scopus 로고    scopus 로고
    • The moonlighting enzyme CD13: Old and new functions to target
    • Mina-Osorio, P. (2008). The moonlighting enzyme CD13: old and new functions to target. Trends Mol. Med. 14, 361-371.
    • (2008) Trends Mol. Med. , vol.14 , pp. 361-371
    • Mina-Osorio, P.1
  • 37
    • 0018609721 scopus 로고
    • A simple, versatile, sensitive and volume-independent method for quantitative protein determination which is independent of other external influences
    • Neuhoff, V., Philipp, K., Zimmer, H.G., and Mesecke, S. (1979). A simple, versatile, sensitive and volume-independent method for quantitative protein determination which is independent of other external influences. Hoppe Seylers Z. Physiol. Chem. 360, 1657-1670.
    • (1979) Hoppe Seylers Z. Physiol. Chem. , vol.360 , pp. 1657-1670
    • Neuhoff, V.1    Philipp, K.2    Zimmer, H.G.3    Mesecke, S.4
  • 38
    • 80053521469 scopus 로고    scopus 로고
    • Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model
    • Noth, R., Lange-Grumfeld, J., Stuber, E., Kruse, M.L., Ellrichmann, M., Hasler, R., Hampe, J., Bewig, B., Rosenstiel, P., Schreiber, S., et al. (2011). Increased intestinal permeability and tight junction disruption by altered expression and localization of occludin in a murine graft versus host disease model. BMC Gastroenterol. 11, 109.
    • (2011) BMC Gastroenterol. , vol.11 , pp. 109
    • Noth, R.1    Lange-Grumfeld, J.2    Stuber, E.3    Kruse, M.L.4    Ellrichmann, M.5    Hasler, R.6    Hampe, J.7    Bewig, B.8    Rosenstiel, P.9    Schreiber, S.10
  • 40
    • 77953442640 scopus 로고    scopus 로고
    • Future of anticathepsin K drugs: Dual therapy for skeletal disease and atherosclerosis?
    • Podgorski, I. (2009). Future of anticathepsin K drugs: dual therapy for skeletal disease and atherosclerosis? Future Med. Chem. 1, 21-34.
    • (2009) Future Med Chem. , vol.1 , pp. 21-34
    • Podgorski, I.1
  • 41
    • 80054716832 scopus 로고    scopus 로고
    • Increase in the tight junction protein claudin-1 in intestinal inflammation
    • Poritz, L.S., Harris, L.R., 3rd, Kelly, A.A., and Koltun, W.A. (2011). Increase in the tight junction protein claudin-1 in intestinal inflammation. Dig. Dis. Sci. 56, 2802-2809.
    • (2011) Dig. Dis. Sci. , vol.56 , pp. 2802-2809
    • Poritz, L.S.1    Harris III, L.R.2    Kelly, A.A.3    Koltun, W.A.4
  • 42
    • 0033802292 scopus 로고    scopus 로고
    • Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages
    • Punturieri, A., Filippov, S., Allen, E., Caras, I., Murray, R., Reddy, V., and Weiss, S.J. (2000). Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J. Exp. Med. 192, 789-799.
    • (2000) J. Exp. Med. , vol.192 , pp. 789-799
    • Punturieri, A.1    Filippov, S.2    Allen, E.3    Caras, I.4    Murray, R.5    Reddy, V.6    Weiss, S.J.7
  • 43
    • 79953751008 scopus 로고    scopus 로고
    • Osteoporosis: Now and the future
    • Rachner, T.D., Khosla, S., and Hofbauer, L.C. (2011). Osteoporosis: now and the future. Lancet 377, 1276-1287.
    • (2011) Lancet , vol.377 , pp. 1276-1287
    • Rachner, T.D.1    Khosla, S.2    Hofbauer, L.C.3
  • 44
    • 77957855881 scopus 로고    scopus 로고
    • Specialized roles for cysteine cathepsins in health and disease
    • Reiser, J., Adair, B., and Reinheckel, T. (2010). Specialized roles for cysteine cathepsins in health and disease. J. Clin. Invest. 120, 3421-3431.
    • (2010) J. Clin. Invest. , vol.120 , pp. 3421-3431
    • Reiser, J.1    Adair, B.2    Reinheckel, T.3
  • 47
    • 84874661796 scopus 로고    scopus 로고
    • Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice
    • DOI 10.1136/gutjnl-2011-300076
    • Sina, C., Lipinski, S., Gavrilova, O., Aden, K., Rehman, A., Till, A., Rittger, A., Podschun, R., Meyer-Hoffert, U., Haesler, R., et al. (2012). Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. Gut. DOI 10.1136/gutjnl-2011- 300076.
    • (2012) Gut.
    • Sina, C.1    Lipinski, S.2    Gavrilova, O.3    Aden, K.4    Rehman, A.5    Till, A.6    Rittger, A.7    Podschun, R.8    Meyer-Hoffert, U.9    Haesler, R.10
  • 48
    • 52649142110 scopus 로고    scopus 로고
    • Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycininduced pulmonary fibrosis
    • Srivastava, M., Steinwede, K., Kiviranta, R., Morko, J., Hoymann, H.G., Langer, F., Buhling, F., Welte, T., and Maus, U.A. (2008). Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycininduced pulmonary fibrosis. Respir. Res. 9, 54.
    • (2008) Respir. Res. , vol.9 , pp. 54
    • Srivastava, M.1    Steinwede, K.2    Kiviranta, R.3    Morko, J.4    Hoymann, H.G.5    Langer, F.6    Buhling, F.7    Welte, T.8    Maus, U.A.9
  • 49
    • 0034502852 scopus 로고    scopus 로고
    • Cathepsin K in thyroid epithelial cells: Sequence, localization and possible function in extracellular proteolysis of thyroglobulin
    • Tepel, C., Bromme, D., Herzog, V., and Brix, K. (2000). Cathepsin K in thyroid epithelial cells: sequence, localization and possible function in extracellular proteolysis of thyroglobulin. J. Cell Sci. 113 Pt 24, 4487-4498.
    • (2000) J. Cell Sci. , vol.113 , Issue.24 , pp. 4487-4498
    • Tepel, C.1    Bromme, D.2    Herzog, V.3    Brix, K.4
  • 50
    • 0030271572 scopus 로고    scopus 로고
    • Macromolecular organization of basement membranes
    • Timpl, R. (1996). Macromolecular organization of basement membranes. Curr. Opin. Cell Biol. 8, 618-624.
    • (1996) Curr. Opin. Cell Biol. , vol.8 , pp. 618-624
    • Timpl, R.1
  • 51
    • 67649589450 scopus 로고    scopus 로고
    • Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases
    • Vreemann, A., Qu, H., Mayer, K., Andersen, L.B., Stefana, M.I., Wehner, S., Lysson, M., Farcas, A.M., Peters, C., Reinheckel, T., et al. (2009). Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases. Biol. Chem. 390, 481-492.
    • (2009) Biol. Chem. , vol.390 , pp. 481-492
    • Vreemann, A.1    Qu, H.2    Mayer, K.3    Andersen, L.B.4    Stefana, M.I.5    Wehner, S.6    Lysson, M.7    Farcas, A.M.8    Peters, C.9    Reinheckel, T.10
  • 53
    • 18944365919 scopus 로고    scopus 로고
    • The role of cathepsins in osteoporosis and arthritis: Rationale for the design of new therapeutics
    • Yasuda, Y., Kaleta, J., and Bromme, D. (2005). The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics. Adv. Drug Deliv. Rev. 57, 973-993.
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 973-993
    • Yasuda, Y.1    Kaleta, J.2    Bromme, D.3


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