A 3 adenosine receptor mediates apoptosis in 5637 human bladder cancer cells by G q protein/PKC-dependent AIF upregulation

Cellular Physiology and Biochemistry

Volumn 30, Issue 5, 2012, Pages 1159-1168

  Kanno, Takeshi ^a   Gotoh, Akinobu ^a   Fujita, Yumiko ^a   Nakano, Takashi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Apoptosis; Apoptosis inducing factor; Bladder cancer cell

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENYLATE CYCLASE; APOPTOSIS INDUCING FACTOR; FORSKOLIN; PROTEIN KINASE C; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CELL CULTURE; GENE CONSTRUCT; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADENOSINE; APOPTOSIS; APOPTOSIS INDUCING FACTOR; DIHYDROPYRIDINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; INDOLES; MALEIMIDES; OLIGOPEPTIDES; PROTEIN KINASE C; RECEPTOR, ADENOSINE A3; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84869228847     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000343306     Document Type: Article

References (19)

1. Candé C, Cecconi F, Dessen P, Kroemer G: Apoptosis-inducing factor (AIF): Key to the conserved caspaseindependent pathways of cell death? J Cell Sci 2002;115:4727-4734. (Pubitemid 36054627)
2. Daugas E, Susin SA, Zamzami N, Ferri KF, Irinopoulou T, Larochette N, Prévost MC, Leber B, Andrews D, Penninger J, Kroemer G: Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis. FASEB J 2000;14:729-739. (Pubitemid 30198571)
3. Ye H, Cande C, Stephanou NC, Jiang S, Gurbuxani S, Larochette N, Daugas E, Garrido C, Kroemer G, Wu H: DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat Struct Biol 2002;9:680-684. (Pubitemid 34977301)
4. Bilyy R, Kit Y, Hellman U, Stoika R: AMID: New insights on its intracellular localization and expression at apoptosis. Apoptosis 2008;13:729-732.
5. Tsuchiya A, Kanno T, Saito M, Miyoshi Y, Gotoh A, Nakano T, Nishizaki T: Intracellularly transported adenosine induces apoptosis in MCF-7 human breast cancer cells by accumulating AMID in the nucleus. Cancer Lett 2012;321:65-72.
6. Yang D, Yaguchi T, Nagata T, Gotoh A, Dovat S, Song C, Nishizaki T: AMID mediates adenosine-induced caspase-independent HuH-7 cell apoptosis. Cell Physiol Biochem 2011;27:37-44.
7. Saitoh M, Nagai K, Nakagawa K, Yamamura T, Yamamoto S, Nishizaki T: Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem Pharmacol 2004;67:2005-2011. (Pubitemid 38591388)
8. Yang D, Yaguchi T, Nakano T, Nishizaki T: Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells. Cell Physiol Biochem 2011;27:71-78.
9. Nogi Y, Kanno T, Nakano T, Fujita Y, Tabata C, Fukuoka K, Gotoh A, Nishizaki T: AMP converted from intracellularly transported adenosine upregulates p53 expression to induce malignant pleural mesothelioma cell apoptosis. Cell Physiol Biochem 2012;30:61-74.
10. Yang D, Yaguchi T, Yamamoto H, Nishizaki T: Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation. Biochem Pharmacol 2007;73:1665-1675. (Pubitemid 46527539)
11. Yang D, Yaguchi T, Nakano T, Nishizaki T: Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells. Cell Biol Toxicol 2010;26:319-330.
12. Moro S, Spalluto G, Jacobson KA: Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example. Trends Pharmacol Sci 2005;26:44-51. (Pubitemid 40052709)
13. Saito M, Yaguchi T, Yasuda Y, Nakano T, Nishizaki T: Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors. Cancer Lett 2010;290:211-215.
14. Sai K, Yang D, Yamamoto H, Fujikawa H, Yamamoto S, Nagata T, Saito M, Yamamura T, Nishizaki T: A1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosineinduced RCR-1 astrocytoma cell death. Neurotoxicol 2006;27:458-467. (Pubitemid 43867776)
15. 2a adenosine receptors. J Gastroenterol 2009;44:56-65.
16. Kamiya H, Kanno T, Fujita Y, Gotoh A, Nakano T, Nishizaki T: Apoptosis-related gene transcription in human A549 lung cancer cells via A3 adenosine receptor. Cell Physiol Biochem 2012;29:687-696.
17. Otsuki T, Kanno T, Fujita Y, Tabata C, Fukuoka K, Nakano T, Gotoh A, Nishizaki T: A3 adenosine receptormediated p53-dependent apoptosis in Lu-65 human lung cancer cells. Cell Physiol Biochem 2012;30:210-220.
18. Kanno T, Nakano T, Fujita Y, Gotoh A, Nishizaki T: Adenosine induces apoptosis in SBC-3 human lung cancer cells through A3 adenosine receptor-dependent AMID upregulation. Cell Physiol Biochem 2012;30:666-676.
19. Nagaya H, Gotoh A, Kanno T, Nishizaki T: A3 adenosine receptor mediates apoptosis in in vitro RCC4-VHL human renal cancer cells by upregulating AMID expression. J Urology 2012; in press.