Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors

Cancer Letters

Volumn 290, Issue 2, 2010, Pages 211-215

  Saito, Masaru ^a   Yaguchi, Takahiro ^a   Yasuda, Yoshiyuki ^a   Nakano, Takashi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

A1 adenosine receptor; Adenosine; Apoptosis; CW2 cell; Human colonic cancer

Indexed keywords

2 CHLOROADENOSINE; 8 CYCLOPENTYLTHEOPHYLLINE; 9 (2 HYDROXY 3 NONYL)ADENINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE DEAMINASE INHIBITOR; ADENYLATE CYCLASE INHIBITOR; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; N (2 PHENYLCYCLOPENTYL)AZACYCLOTRIDECAN 2 IMINE;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER CELL; CANCER REGRESSION; COLON CANCER; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; INOCULATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; ENZYME ACTIVATION; HUMANS; MICE; RECEPTOR, ADENOSINE A1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MUS;

EID: 77649183200     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2009.09.011     Document Type: Article

References (13)

1. Saitoh M., Nagai K., Nakagawa K., Yamamura T., Yamamoto S., and Nishizaki T. Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem. Pharmacol. 67 (1994) 2005-2011
2. Yang D., Yaguchi T., Yamamoto H., and Nishizaki T. Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation. Biochem. Pharmacol. 73 (2007) 1665-1675
3. Vintermyr O.K., Gjertsen B.T., Lanotte M., and Doskeland S.O. Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells. Exp. Cell Res. 206 (1993) 157-161
4. Boe R., Gjertsen B.T., Doskeland S.O., and Vintermyr O.K. 8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line. Br. J. Cancer 72 (1995) 1151-1159
5. Pratt R.M., and Martin G.R. Epithelial cell death and cyclic AMP increase during palatal development. Proc. Natl. Acad. Sci. USA 72 (1975) 874-877
6. 3 adenosine receptor agonist, in human lung cancer cells. Cancer Lett. 264 (2008) 309-315
7. Panjehpour M., and Karami-Tehrani F. Adenosine modulates cell growth in the human breast cancer cells via adenosine receptors. Oncol. Res. 16 (2007) 575-585
8. 3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-kappaB signal transduction pathways. Int. J. Oncol. 33 (2008) 287-295
9. S. Morello, R. Sorrentino, A. Porta, G. Forte, A. Popolo, A. Petrella, A. Pinto, Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-κB signalling pathway in thyroid cancer cells, J. Cell. Physiol., in press.
10. 1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death. Neurotoxicology 27 (2006) 458-467
11. 2a adenosine receptors. J. Gastroenterol. 44 (2009) 56-65
12. Thorburn A. Death receptor-induced cell killing. Cell. Signal. 16 (2004) 139-144
13. Earnshaw W.C., Martins L.M., and Kaufmann S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68 (1999) 383-424