Adenosine activates AMPK to phosphorylate Bcl-X L responsible for mitochondrial damage and diablo release in HuH-7 cells

Cellular Physiology and Biochemistry

Volumn 27, Issue 1, 2011, Pages 71-78

  Yang, Donqin ^a,b   Yaguchi, Takahiro ^a   Nakano, Takashi ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Adenosine; AMPK; Apoptosis; DIABLO; HuH 7 cell; Mitochondria; Phosphorylation

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE; CASPASE 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MUTANT PROTEIN; PLASMID DNA; PROTEIN BCL XL; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SERINE; SMALL INTERFERING RNA; THREONINE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE; GENE SILENCING; HEPATOMA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 79951666404     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000325207     Document Type: Article

References (17)

1. Yang D, Yaguchi T, Yamamoto H, Nishizaki T: Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation. Biochem Pharmacol 2007;73:1665-1675. (Pubitemid 46527539)
2. L /DIABLO/ IAP expression in HuH-7 human hepatoma cells. Cell Biol Toxicol 2010;26:319-330.
3. Saitoh M, Nagai K, Nakagawa K, Yamamura T, Yamamoto S, Nishizaki T: Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem Pharmacol 2004;67:2005-2011. (Pubitemid 38591388)
4. Bae EJ, Cho MJ, Kim SG: Metformin prevents an adaptive increase in GSH and induces apoptosis under the conditions of GSH deficiency in H4IIE cells. J Toxicol Environ Health A 2007;70:1371-1380. (Pubitemid 47124005)
5. Hardie DG, Carling D, Carlson M: The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 1998;67:821-855. (Pubitemid 28411146)
6. Kemp BE, Mitchelhill KI, Stapleton D, Michell BJ, Chen ZP, Witters LA: Dealing with energy demand: the AMP-activated protein kinase. Trends Biochem Sci 1999;24:22-25. (Pubitemid 29074459)
7. Du C, Fang M, Li Y, Li L, Wang X: Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102:33-42.
8. Salvesen GS, Duckett CS: IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 2002;3:401-410. (Pubitemid 34685698)
9. Zhuge J: Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-b-D- ribofuranoside (AICAR). Cell Biol Toxicol 2009;25:253-263.
10. Mukherjee P, Mulrooney TJ, Marsh J, Blair D, Chiles TC, Seyfried TN: Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain. Mol Cancer 2008;7:37.
11. Cory S, Adams JM: The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-656. (Pubitemid 37328916)
12. Kroemer G: The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 1997;3:614-620. (Pubitemid 27264969)
13. Wang X: The expanding role of mitochondria in apoptosis. Genes Dev 2001;15:2922-2933. (Pubitemid 33078942)
14. Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281:1309-1312. (Pubitemid 28406816)
15. Li LY, Luo X, Wang X: Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 2001;412:95-99. (Pubitemid 32851517)
16. Loeffler M, Kroemer G: The mitochondrion in cell death control: certainties and incognita. Exp Cell Res 2000;256:19-26. (Pubitemid 30211162)
17. Susin SA, Lorenzo, HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G: Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 1999;397:441-446.