Adenosine induces apoptosis in SBC-3 human lung cancer cells through A 3 adenosine receptor-dependent AMID upregulation

Cellular Physiology and Biochemistry

Volumn 30, Issue 3, 2012, Pages 666-676

  Kanno, Takeshi ^a   Nakano, Takashi ^a   Fujita, Yumiko ^a   Gotoh, Akinobu ^a   Nishizaki, Tomoyuki ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Adenosine; AMID; Apoptosis; SBC 3 lung cancer cell

Indexed keywords

1,4 DIHYDRO 2 METHYL 6 PHENYL 4 (2 PHENYLETHYNYL) 3,5 PYRIDINEDICARBOXYLIC ACID 5 BENZYL 3 ETHYL ESTER; ADENOSINE A3 RECEPTOR; ADENOSINE A3 RECEPTOR AGONIST; APOPTOSIS INDUCING FACTOR HOMOLOGOUS MITOCHONDRION ASSOCIATED INDUCER OF DEATH; FLUORESCEIN ISOTHIOCYANATE; LIPOCORTIN 5; MESSENGER RNA; PROPIDIUM IODIDE; PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CANCER; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84864408363     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000341447     Document Type: Article

References (17)

1. Saitoh M, Nagai K, Nakagawa K, Yamamura T, Yamamoto S, Nishizaki T: Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochem Pharmacol 2004;67:2005-2011.
2. Yang D, Yaguchi T, Nakano T, Nishizaki T: Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells. Cell Physiol Biochem 2011;27:71-78.
3. Yang D, Yaguchi T, Yamamoto H, Nishizaki T: Intracellularly transported adenosine induces apoptosis in HuH-7 human hepatoma cells by downregulating c-FLIP expression causing caspase-3/-8 activation. Biochem Pharmacol 2007;73:1665-1675.
4. Yang D, Yaguchi T, Nakano T, Nishizaki T: Adenosine-induced caspase-3 activation by tuning Bcl-XL/DIABLO/IAP expression in HuH-7 human hepatoma cells. Cell Biol Toxicol 2010;26:319-330.
5. Saito M, Yaguchi T, Yasuda Y, Nakano T, Nishizaki T: Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A1 adenosine receptors. Cancer Lett 2010:290:211-215.
6. Sai K, Yang D, Yamamoto H, Fujikawa H, Yamamoto S, Nagata T, Saito M, Yamamura T, Nishizaki T: A1 adenosine receptor signal and AMPK involving caspase-9/-3 activation are responsible for adenosine-induced RCR-1 astrocytoma cell death. Neurotoxicol 2006;27:458-467.
7. Yasuda Y, Saito M, Yamamura T, Yaguchi T, Nishizaki T: Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A2a adenosine receptors. J Gastroenterol 2009;44:56-65.
8. Bar-Yehuda S, Stemmer SM, Madi L, Castel D, Ochaion A, Cohen S, Barer F, Zabutti A, Perez-Liz G, Del Valle L, Fishman P: The A3 adenosine receptor agonist CF102 induces apoptosis of hepatocellular carcinoma via de-regulation of the Wnt and NF-κB signal transduction pathways. Int J Oncol 2008;33:287-295.
9. Kim SJ, Min HY, Chung HJ, Park EJ, Hong JY, Kang YJ, Shin DH, Jeong LS, Lee SK: Inhibition of cell proliferation through cell cycle arrest and apoptosis by thio-Cl-IB-MECA, a novel A3 adenosine receptor agonist, in human lung cancer cells. Cancer Lett 2008;264:309-315.
10. Morello S, Sorrentino R, Porta A, Forte G, Popolo A, Petrella A, Pinto A: Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-κB signaling pathway in thyroid cancer cells. J Cell Physiol 2009;221:378-386.
11. Panjehpour M, Karami-Tehrani F: Adenosine modulates cell growth in the human breast cancer cells via adenosine receptors. Oncol Res 2007;16:575-585.
12. Bilyy R, Kit Y, Hellman U, Stoika R: AMID: new insights on its intracellular localization and expression at apoptosis. Apoptosis 2008;13:729-732.
13. Yang D, Yaguchi T, Nagata T, Gotoh A, Dovat S, Song C, Nishizaki T: AMID mediates adenosine-induced caspase-independent HuH-7 cell apoptosis. Cell Physiol Biochem 2011;27:37-44.
14. Kamiya H, Kanno T, Fujita Y, Gotoh A, Nakano T, Nishizaki T: Apoptosis-related gene transcription in human A549 lung cancer cells via A3 adenosine receptor. Cell Physiol Biochem 2012;29:687-696.
15. Moro S, Spalluto G, Jacobson KA: Techniques: Recent developments in computer-aided engineering of GPCR ligands using the human adenosine A3 receptor as an example. Trends Pharmacol Sci 2005;26:44-51.
16. Tsuchiya A, Kanno T, Saito M, Miyoshi Y, Gotoh A, Nakano T, Nishizaki T: Intracellularly transported adenosine induces apoptosis in MCF-7 human breast cancer cells by accumulating AMID in the nucleus. Cancer Lett 2012;321:65-72.
17. Otsuki T, Kanno T, Fujita Y, Tabata C, Fukuoka K, Nakano T, Gotoh A, Nishizaki T: A3 adenosine receptor-mediated p53-dependent apoptosis in Lu-65 human lung cancer cells. Cell Physiol Biochem 2012;30:210-220.