Leishmanicidal, antiproteolytic and antioxidant evaluation of natural biflavonoids isolated from Garcinia brasiliensis and their semisynthetic derivatives

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 613-623

  Gontijo, Vanessa Silva ^a   Judice, Wagner A S ^b   Codonho, Barbara ^a   Pereira, Ivan Oliveira ^a,c   Assis, Diego Magno ^d   Januário, Jaqueline Pereira ^a   Caroselli, Elide E ^d   Juliano, Maria Aparecida ^d   De Carvalho Dosatti, Amanda ^b   Marques, Marcos José ^a   Junior, Claudio Viegas ^a   Santos, Marcelo Henrique Dos ^a  

^a FEDERAL UNIVERSITY OF ALFENAS   (Brazil)

^b UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

^c University Vale of Rio Verde   (Brazil)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Antioxidants; Antiproteolytic; Biflavonoids; Garcinia brasiliensis; Leishmania amazonensis; Natural products; Semisynthesis

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETIC ACID ETHYL ESTER; ANTILEISHMANIAL AGENT; ANTIOXIDANT; ASCORBIC ACID; BIOFLAVONOID; BUTYLCRESOL; FUKUGISIDE; GARCINIA BRASILIENSIS EXTRACT; MORELLOFLAVONE; MORELLOFLAVONE 4''' O BETA DEXTRO GLYCOSYL; MORELLOFLAVONE 7,4',7''',3''',4''' PENTA O BUTANOYL; MORELLOFLAVONE 7,4',7''',3''',4''' PENTA O METHYL; MORELLOFLAVONE 7,4',7'',3''',4''' PENTA O ACETYL; PHENOL; PLANT EXTRACT; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ACYLATION; ALKYLATION; AMASTIGOTE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL LYSATE; CELL VACUOLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; ENZYME INHIBITION; EPICARP; GARCINIA BRASILIENSIS; LEISHMANIA; LIPOPHILICITY; MEDICINAL PLANT; NONHUMAN; PERITONEUM MACROPHAGE; PH; PROMASTIGOTE;

ANIMALS; ANTIOXIDANTS; ANTIPROTOZOAL AGENTS; BIFLAVONOIDS; BIOLOGICAL AGENTS; CYSTEINE PROTEASES; CYSTEINE PROTEINASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; GARCINIA; LEISHMANIA; MICE; MOLECULAR CONFORMATION; PARASITIC SENSITIVITY TESTS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869214009     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.06.021     Document Type: Article

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