Relationships between the chromatographic hydrophobicity indices and solute descriptors obtained by using several reversed-phase, diol, nitrile, cyclodextrin and immobilised artificial membrane-bonded high-performance liquid chromatography columns

Journal of Chromatography A

Volumn 797, Issue 1-2, 1998, Pages 41-55

  Valko K ^a   Plass, M ^b   Bevan, C ^a   Reynolds, D ^a   Abraham, M H ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Chemometrics; Hydrophobicity index; Immobilised artificial membranes; Principal component analysis; Solute descriptors; Stationary phases, LC

Indexed keywords

AMPHOLYTE; CYCLODEXTRIN; CYCLOHEXANE; NITRILE; OCTANOL; WATER;

ARTIFICIAL MEMBRANE; BLOOD BRAIN BARRIER; CALIBRATION; CHEMICAL COMPOSITION; CHEMOMETRIC ANALYSIS; CONFERENCE PAPER; HYDROGEN BOND; HYDROPHOBICITY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLVATION;

EID: 0032570997     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(97)00961-8     Document Type: Conference Paper

References (41)

1. Meyer H. Arch. Exp. Pathol. Pharmacol. 42:1899;109.
2. Overton E. Z. Phys. Chem. 22:1987;189.
3. Hansch C., Fujita T. J. Am. Chem. Soc. 86:1964;1616.
4. Leo A., Hansch C., Elkins D. Chem. Rev. 7:1971;525.
5. Hansch C., Leo A. Chem. Rev. 91:1993;1281.
6. R. Mannhold, H. Kubinyi, H. Timmerman, in: V. Pilska, B. Testa, H. van de Waterbeemd (Eds.), Methods and Principles in Medicinal Chemistry, Vol. 4, Lipophilicity in Drug Action and Toxicology, VCH, Weinheim, New York, 1996.
7. R.F. Rekker, The Hydrophobic Fragmental Constant, Pharmacochemistry Library, Vol. 1, Elsevier, Amsterdam, 1997.
8. C. Hansch, A. Leo, cLog P program, Pomona, CA, USA.
9. Pallas for Windows, ProLog P Module, CompuDrug Chemistry, Budapest, V. 2. 1994.
10. ACD/log P, Advanced Chemistry Development, Toronto, V. 1. 1996.
11. Collander R. Acta Physiol. Scand. 13:1947;363.
12. A. Leo, in: R.G. Gould (Ed.), Biological Correlations - The Hansch Approach (Advances in Chemistry Ser. 114), America Chemical Society, Washington, DC, 1972, p. 51.
13. Kamlet M.J., Doherty R.M., Abboud J.-L.M., Abraham M.H., Taft R.W. CHEMTECH. 16:1986;566.
14. Abraham M.H., Doherty R.M., Kamlet M.J., Taft R.W. Chem. Brit. 22:1986;551.
15. Abraham M.H. Chem. Soc. Rev. 22:1993;660.
16. M.H. Abraham, University College London DataBase, 1997.
17. Abraham M.H., McGowan J.C. Chromatographia. 23:1987;243.
18. M.H. Abraham, H.S. Chadha, in: V. Pilska, B. Testa, H. van de Waterbeemd (Eds.), Lipophilicity in Drug Action and Toxicology, VCH, Weinheim, 1996.
19. Abraham M.H., Roses M. J. Phys. Org. Chem. 7:1994;672.
20. Abraham M.H., Chadha H.S., Leitao R.A.E., Mitchell R.C., Lambert W.J., Kaliszan R., Nasal A., Haber P. J. Chromatogr. A. 766:1997;35.
21. Mirrlees M.S., Moulton S.J., Murphy C.T., Taylor P.J. J. Med. Chem. 19:1976;619.
22. Unger S.H., Cook J.R., Hollenberg J.S. J. Pharm. Sci. 67:1978;1364.
23. Braumann Th., Weber G., Grimme L.H. J. Chromatogr. 261:1983;329.
24. Lambert W.J. J. Chromatogr. A. 656:1993;469.
25. Harnisch M., Mockel H.J., Schulze G.J. J. Chromatogr. 282:1983;315.
26. K. Valkó, in: H. Kalász, L. Ettre (Eds.), Chromatography - The State of the Art, Akadémia, Budapest, 1995, p. 739.
27. Valkó K. J. Liq. Chromatogr. 7:1984;1405.
28. Valkó K., Slégel P. J. Chromatogr. 631:1993;49.
29. Valkó K., Bevan C., Reynolds D. Anal. Chem. 69:1997;2022.
30. Krass J.D., Jastorff B., Genieser H.-G. Anal. Chem. 69:1997;2575.
31. Pidgeon C., Venkatarum U.V. Anal. Biochem. 176:1989;36.
32. M.H. Abraham, M. Roses, C.F. Poole, S. Poole, J. Chromatogr. A, in press.
33. Nasal A., Sznitowska M., Bucinski A., Kaliszan R. J. Chromatogr. A. 692:1995;83.
34. Mikake K., Kitaura F., Mizuno N., Terada H. J. Chromatogr. 389:1987;47.
35. Abraham M.H., Chadha H.S., Whiting G.S., Mitchell R.C. J. Pharm. Sci. 83:1994;1085.
36. Abraham M.H., Chadha H.S., Leo A.J. J. Chromatogr. A. 685:1994;203.
37. Abraham M.H., Chadha H.S., Mitchell R.C. J. Pharm. Sci. 83:1994;1257.
38. Jackson P.T., Schure M.R., Weber T.P., Carr P.W. Anal. Chem. 69:1997;416.
39. Sándi Á., Bede Á., Szepesy L., Rippel G. Chromatographia. 45:1997;206.
40. Carr P.W., Doherty R.M., Kamlet M.J., Taft R.W., Melander W., Horváth Cs. Anal. Chem. 58:1986;2674.
41. Cruz E., Euerby M.R., Johnson C.M., Hackett C.A. Chromatographia. 44:1997;151.