Natural polyprenylated benzophenones inhibiting cysteine and serine proteases

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1230-1239

  Martins, Felipe T ^a   Assis, Diego M ^a   dos Santos, Marcelo H ^a   Camps, I ^a   Veloso, Márcia P ^a   Juliano, Maria A ^b   Alves, Lira C ^a   Doriguetto, Antônio C ^a  

^a FEDERAL UNIVERSITY OF ALFENAS   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Benzophenones; Cathepsin G; Flexible docking; Guttiferone A; Proteases; SAR

Indexed keywords

2,2',4 TRIHYDROXYBENZOPHENONE; ANTINEOPLASTIC AGENT; BENZOPHENONE DERIVATIVE; CATHEPSIN B; CATHEPSIN G; CHYMOSTATIN; CYSTEINE PROTEINASE INHIBITOR; DIPHENYLMETHANONE; EPICLUSIANONE; GARCINIA BRASILIENSIS EXTRACT; GARCINIAPHENONE; GUTTIFERONE A; PAPAIN; PLANT EXTRACT; SERINE PROTEINASE INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ISOLATION; DRUG PROTEIN BINDING; GARCINIA; GARCINIA BRASILIENSIS; IC 50; PRENYLATION; PROTEIN DEGRADATION; SIMULATION; STRUCTURE ACTIVITY RELATION;

BENZOPHENONES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE PROTEINASE INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SERINE PROTEINASE INHIBITORS; SPECTRUM ANALYSIS;

EID: 60549087694     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.018     Document Type: Article

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