Selective inhibition of phosphodiesterase 1 relaxes urinary bladder smooth muscle: Role for ryanodine receptor-mediated BK channel activation

American Journal of Physiology - Cell Physiology

Volumn 303, Issue 10, 2012, Pages

  Xin, Wenkuan ^a   Soder, Rupal P ^a   Cheng, Qiuping ^a   Rovner, Eric S ^b   Petkov, Georgi V ^a,b  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

8MM IBMX; Contractility; Patch clamp; Paxilline; Ryanodine

Indexed keywords

8 METHOXYMETHYL 3 ISOBUTYL 1 METHYLXANTHINE; CYCLIC AMP; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; METHYLXANTHINE DERIVATIVE; PAXILLINE; PHOSPHODIESTERASE I; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; DETRUSOR MUSCLE; ELECTRIC FIELD; ENZYME INHIBITION; GUINEA PIG; HUMAN; HUMAN CELL; HYPERPOLARIZATION; INFORMATION PROCESSING; ISOMETRICS; MEMBRANE POTENTIAL; MUSCLE CONTRACTILITY; MUSCLE RELAXATION; MUSCLE STRENGTH; MUSCLE TONE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

1-METHYL-3-ISOBUTYLXANTHINE; ANIMALS; CELLS, CULTURED; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 1; ELECTRIC STIMULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GUINEA PIGS; HUMANS; ISOENZYMES; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MEMBRANE POTENTIALS; MUSCLE RELAXATION; MUSCLE, SMOOTH; PATCH-CLAMP TECHNIQUES; PHOSPHODIESTERASE INHIBITORS; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SIGNAL TRANSDUCTION; TISSUE CULTURE TECHNIQUES; URINARY BLADDER; XANTHINES;

CAVIA;

EID: 84869210284     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00162.2012     Document Type: Article

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