Initial clinical experience with the selective phosphodiesterase-l isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder

World Journal of Urology

Volumn 18, Issue 6, 2000, Pages 439-443

  Truss, Michael C ^a   Stief, Christian G ^a   Ückert, Stefan ^a   Becker, Armin J ^a   Schultheiss, Dirk ^a   Machtens, Stefan ^a   Tonas, Udo ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ISOENZYME; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; VINCA ALKALOID; VINPOCETINE;

ARTICLE; BLADDER; BLADDER DISEASE; CLINICAL TRIAL; COMPLIANCE (PHYSICAL); DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HUMAN; MALE; MIDDLE AGED; PATHOPHYSIOLOGY; PILOT STUDY; URINE INCONTINENCE; URODYNAMICS;

COMPLIANCE; FEMALE; HUMANS; ISOENZYMES; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PILOT PROJECTS; URINARY BLADDER; URINARY BLADDER DISEASES; URINARY INCONTINENCE; URODYNAMICS; VINCA ALKALOIDS;

EID: 0034577690     PISSN: 07244983     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00007088     Document Type: Article

References (20)

1. Andersson KE, Cardozo LD, Chappie C, Drutz HP, Finkbeiner AE, Haab F, Vela Navarete R (1999) Pharmacological treatment of urinary incontinence. In: Abrams P, Khoury S, Wein A (eds) Incontinence. Health Publication Ltd., Plymouth, UK 449-486
2. Andersson KE (1993) Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 45: 253-308
3. Andersson KE, Stief CG (1997) Neurotransmission and the contraction and relaxation of penile erectile tissues. World J Urol 15: 14-20
4. Andersson KE, Appell R, Cardozo LD, Chappie C, Drutz HP, Finkbeiner AE, Haab F, Vela Navarete R (1999) The phar-macological treatment of urinary incontinence. BJU Int 84: 923-947
5. Eglen RM, Hedge SS, Watson N (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 48: 531-565
6. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA (1998) Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 338: 1397-1404
7. Hadjiev D, Yancheva S (1976) Rheoencephalographic and psychological studies with ethyl apovincamate in cerebral vascular insufficiency. Arzneimittelforschung 26: 1947-1950
8. Hall IP (1993) Isoenzyme selective phosphodiesterase inhibitors: potential clinical uses. Br J Clin Pharmacol 35: 1-7
9. Miyazaki M (1995) The effect of a cerebral vasodilator, vinpocetine, on cerebral vascular resistance evaluated by the Doppler ultrasonic technique in patients with cerebrovascular diseases. Angiology 46: 53-58
10. Nicholson CD, Challiss RA, Shahid M (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol Sci 12: 19-27
11. Page C, Torphy T PDE inhibitors: drugs with an expanding range of therapeutic uses. William Harvey Research Conference, Nice, France, 1-3 December, abstract book
12. Schudt C, Dent G, Rabe KF (1996) Phosphodiesterase inhibitors. In: Page E (ed) The handbook of immunpharmacology. Academic, London
13. Soderling SH, Bayuga SJ, Beavo JA (1999) Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci USA 96: 7071-7076
14. Somlyo AP, Somlyo AV (1994) Signal transduction and regulation in smooth muscle. Nature 372: 231-236
15. Thai LJ, Salmon DP, Lasker B, Bower D, Klauber MR (1989) The safety and lack of efficiency of vinpocetine in Alzheimer's disease. J Am Geriatr Soc 37: 515-520
16. Truss MC, Uckert S, Stief CG et al (1995) Porcine detrusor cyclic nucleotide phosphodiesterase isoenzymes: characterization and functional effects of various phosphodiesterase inhibitors in vitro. Urology 45: 893-901
17. Truss MC, Ückert S, Stief CG, Forssmann WG, Jonas U (1996) Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle: II Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels. Urol Res 24: 129-134
18. Truss MC, Ückert S, Stief CG, Kuczyk M, Forssmann WG. Jonas U (1996) Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle: I. Identification and characterization. Urol Res 24: 123-128
19. Vinpocetine product information, Thiemann Pharmaceuticals
20. Wagner TH, Hu TW (1998) Economic costs of urinary incontinence in 1995. Urology 51: 355-361