Effects of various phosphodiesterase-lnhibitors, forskolin, and sodium nitroprusside on porcine detrusor smooth muscle tonic responses to muscarinergic stimulation and cyclic nucleotide levels in vitro

Neurourology and Urodynamics

Volumn 15, Issue 1, 1996, Pages 59-70

  Truss, Michael C ^a   Ückert, Stefan ^a   Stief, Christian G ^a   Kuczyk, Markus ^a   Schulz Knappe, Peter ^b   Forssmann, Wolf Georg ^b   Jonas, Udo ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b IPF PHARMACEUTICALS GMBH   (Germany)

Author keywords

cAMP; cGMP; Detrusor; Phosphodiesterase

Indexed keywords

CYCLIC AMP; CYCLIC GMP; DIPYRIDAMOLE; FORSKOLIN; MILRINONE; NITROPRUSSIDE SODIUM; PAPAVERINE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; VINPOCETINE; ZAPRINAST;

ANIMAL TISSUE; ARTICLE; DETRUSOR MUSCLE; IN VITRO STUDY; NONHUMAN; SMOOTH MUSCLE TONE; SWINE;

ADENYLATE CYCLASE; ANIMALS; CYCLIC AMP; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; FORSKOLIN; GUANYLATE CYCLASE; MUSCLE CONTRACTION; MUSCLE RELAXATION; MUSCLE, SMOOTH; NITROPRUSSIDE; NUCLEOTIDES, CYCLIC; PHOSPHODIESTERASE INHIBITORS; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; SWINE; URINARY BLADDER; VASODILATOR AGENTS;

EID: 0029928905     PISSN: 07332467     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6777(1996)15:1<59::AID-NAU6>3.0.CO;2-E     Document Type: Article

References (37)

1. Andersson KE (1988): Current concepts in the treatment of disorders of micturition. Drugs 35:477-494.
2. Andersson KE ( 1990): Autonomie neurotransmission and the unstable bladder. Neurourol Urodyn 9:555-557.
3. Andersson KE (1993): Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 45:253-308.
4. Andersson KE, Hedlund H. (1990): Basic and clinical aspects of cholinergic agents in bladder dysfunction. Prog Brain Res 84:201-7.
5. Andersson KE, Fovaeus M, Hedlund H (1988): Urogenital muscarinic receptors and drug effects. Ann Clin Res 20:356-66.
6. Beavo, J (1990): Multiple phosphodiesterase isoenzymes: Background, nomenclature and implications. In Beavo J, Houslay MD (eds): "Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action." New York: Wiley.
7. Cardozo LD, Stanton SL (1979): An objective comparison of the effects of parenterally administered drugs in patients suffering from detrusor instability. J Urol 122:58-59.
8. Cardozo LD, Cooper D, Versi E (1987): Oxybutynin chloride in the management of idiopathic detrusor instability. Neurourol Urodyn 6:256-257.
9. Guarneri L, Ibba M, Angelico P, Testa R (1991): Effects of oxybutynin, terodiline, and nifedipine on the cystometrogram in conscious rats with infravesical outflow obstruction. Pharmacol Res 24:263-72.
10. Guarneri L, Robinson E, Testa R (1994): A review of flavoxate: Pharmacology and mechanism of action. Drugs Today 30:91-98.
11. Hall IP (1993): Isoenzyme selective phosphodiesterase inhibitors: Potential clinical uses. Br J Clin Pharmacol 35:1-7.
12. Hedlund H, Mattiasson A, Andersson KE(1991): Effects of pinacidil on detrusor instability in men with bladder outlet obstruction. J Urol 146:1345-7.
13. ATP channel opener with in vivo selectivity for urinary bladder. J Pharmacol Exp Ther 274:884-890.
14. Langtry HD, McTavish D (1990): Terodiline. A review of its pharmacological properties, and therapeutic use in the treatment of urinary incontinence. Drugs 40:748-61.
15. Lincoln TM (1989): Cyclic CMP and mechanisms of vasodilation. Pharmacol Ther 41:479-502.
16. Lincoln TM, Cornwell TL (1991): Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels 28:129-37.
17. Lincoln TM, Cornwell TL (1993): Intracellular cyclic GMP receptor proteins. Faseb J 7:328-38.
18. Lowry OH, Rosebrough H, Farr AL, Randall RJ (1951): Protein measurement with the Folin phenol reagent. J Biol Chem 193:165-275.
19. Morita T, Wheeler MA, Miyagawa I, Kondo S, Weiss RM (1986a): Effects of forskolin on contractility and cyclic AMP levels in rabbit detrusor muscle. Tohoku J Exp Med 149:283-5.
20. Morita T, Dohkita S, Kondo S, Nishimoto T, Hirano S, Tsuchida S (1990): Cyclic adenosine monophosphate production and contractile response induced by beta-adrenoceptor subtypes in rabbit urinary bladder smooth muscle. Urol Int 45:10-5.
21. Morita T, Tsujii T, Dokhita S (1992): Regional difference in functional roles of cAMP and cGMP in lower urinary tract smooth muscle contractility. Urol Int 49:191-5.
22. Morita T, Wheeler MA, Weiss RM (1986b): Relaxant effect of forskolin in rabbit detrusor smooth muscle: Role of cyclic AMP. J Urol 135:1293-5.
23. Nakatsu K (1988): Role of cGMP in relaxation of vascular and other smooth muscle. Can J Physiol Pharmacol 67:251-262.
24. Nicholson CD, Shahid M (1994): Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes: Their potential utility in the therapy of asthma. Pulm Pharmacol 7:1-17.
25. Nicholson CD, Challiss RA, Shahid M (1991): Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol Sci 12:19-27.
26. Nilvebrant L, Andersson KE, Matthiasson A (1985): Characterization of the muscarinic cholinoceptors in the human detrusor. J Urol 134:418-23.
27. Nosálová V, Machová J, Babulova A (1993): Protective action of vinpocetine against experimentally induced gastric damage in rats. Arzneimittel forschung Drug Res 43:891-985.
28. Opie LH (1982): Role of cyclic nucleotides in heart metabolism. Cardiovasc Res 16:483-507.
29. Persson K, Andersson KE (1994): Non-adrenergic, non-cholinergic relaxation and levels of cyclic nucleotides in rabbit lower urinary tract. Eur J Pharmacol 268:159-67.
30. Pharmacia (1991), Dridase (Oxybutynin) Product Information. Erlangen (Germany), Pharmacia GmbH.
31. Reeves ML, England PJ (1990): Cardiac phosphodiesterase and the functional effects of selective inhibition. In Beavo J, Houslay MD (eds): "Cyclic Nucleotide Phosphodiesterases: Structure, Regulation and Drug Action." New York: Wiley.
32. Thompson W J (1991): Cyclic nucleotide phosphodiesterases: Pharmacology, biochemistry and function. Pharmacol Ther 51:13-33.
33. Torphy TJ, Cieslinski LB (1990): Characterization and selective inhibition of cyclic nucleotide phosphodiesterase isoenzymes in canine tracheal smooth muscle. Mol Pharmacol 37:206-214.
34. Torphy TJ, Undem BJ (1991): Phosphodiesterase inhibitors: New opportunities for the treatment of asthma. Thorax 46:512-23.
35. Torphy TJ, Livi GP. Balcarek JM, White JR, Chilton FH, Undem BJ (1992): Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma. Adv Second Messenger Phosphoprotein Res 25:289-305.
36. Truss MC, Ückert S, Stief CG, Schulz-Knappe P, Hess R, Forssmann WG, Jonas U (1995): Porcine detrusor cyclic nucleotide phosphodiesterase (PDE) isoenzymes: Characterization and functional effects of various PDE inhibitors. Urology 45:893-901.
37. Zorzitto ML, Jewett MAS, Fernie GR, Holliday PJ, Bartlett S (1986): Effectiveness of propantheline bromide in the treatment of geriatric patients with detrusor instability. Neurourol Urodyn 5:133-140.