p107 acts as a tumor suppressor in pRb-deficient epidermis

Molecular Carcinogenesis

Volumn 47, Issue 2, 2008, Pages 105-113

  Lara, M Fernanda ^a   Santos, Mirentxu ^a   Ruiz, Sergio ^a,b   Segrelles, Carmen ^a   Moral, Marta ^a   Martínez Cruz, Ana Belén ^a   Hernández, Pilar ^a   Martínez Palacio, Jesús ^a   Lorz, Corina ^a   García Escudero, Ramón ^a   Paramio, Jesús M ^a  

^a CIEMAT   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

Apoptosis; Epidermis; Microarray; p107; p53; pRb; Ras; Tumorigenesis

Indexed keywords

PROTEIN P107; PROTEIN P53; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS; FEMALE; GENE EXPRESSION PROFILING; KERATINOCYTE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE H RAS; PHENOTYPE; PRIORITY JOURNAL; SKIN CARCINOGENESIS; SKIN GRAFT; TUMOR SUPPRESSOR GENE;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELLS, CULTURED; FEMALE; GENE DELETION; GENES, RETINOBLASTOMA; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MICE; MICE, NUDE; RETINOBLASTOMA-LIKE PROTEIN P107; SKIN; SKIN NEOPLASMS;

MUS;

EID: 38949179217     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20367     Document Type: Article

References (35)

1. Classon M, Dyson N. p107 and p130: Versatile proteins with interesting pockets. Exp Cell Res 2001;264:135-147.
2. Attwooll C, Denchi EL, Helm K. The E2F family: Specific functions and overlapping interests. EMBO J 2004;23:4709-4716.
3. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
4. DeGregori J. Surprising dependency for retinoblastoma protein in ras-mediated tumorigenesis. Mol Cell Biol 2006;26:1165-1169.
5. Dannenberg JH, Schuijff L, Dekker M, van der Valk M, Riele HT. Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130. Genes Dev 2004;18:2952-2962.
6. Balsitis SJ, Sage J, Duensing S, Munger K, Jacks T, Lambert PF. Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independrnt effects of E7 in vivo. Mol Cell Biol 2003;23:9094-9103.
7. Ruiz S, Santos M, Segrelles C, et al. Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis. Development 2004;131:2737-2748.
8. Ruiz S, Santos M, Lara MF, Segrelles C, Ballestin C, Paramio JM. Unexpected roles for pRb in mouse skin carcinogenesis. Cancer Res 2005;65:9678-9686.
9. Ruiz S, Santos M, Paramio JM. Is the loss of pRb essential for the mouse skin carcinogenesis? Cell Cycle 2006;5:625-629.
10. Ruiz S, Segrelles C, Bravo A, et al. Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Development 2003;130:2341-2353.
11. Ruiz S, Segrelles C, Santos M, Lara MF, Paramio JM. Functional link between retinoblastoma family of proteins and the Wnt signaling pathway in mouse epidermis. Dev Dyn 2004;230:410-418.
12. Paramio JM, Segrelles C, Ruiz S, et al. The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis. J Biol Chem 2001;276:44203-44211.
13. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003;4:249-264.
14. Vaquerizas JM, Conde L, Yankilevich P, et al. GEPAS, an experiment-oriented pipeline for the analysis of microarray gene expression data. Nucleic Acids Res 2005;33(Web Server issue):W616-W620.
15. Saeed AI, Sharov V, White J, et al. T M4: A free, open-source system for microarray data management and analysis. Biotechniques 2003;34:374-378.
16. Ren B, Cam H, Takahashi Y, et al. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 2002;16:245-256.
17. Ishida S, Huang E, Zuzan H, et al. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol 2001;21:4684-4699.
18. Wei CL, Wu Q, Vega VB, et al. A global map of p53 transcription-factor binding sites in the human genome. Cell 2006;124:207-219.
19. Alfarano C, Andrade CE, Anthony K, et al. The Biomolecular Interaction Network Database and related tools 2005 update. Nucleic Acids Res 2005;33(Database issue):D418-D424.
20. Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 1986;322:78-80.
21. Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88:593-602.
22. Pearson M, Carbone R, Sebastiani C, et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 2000;406:207-210.
23. Smulson ME, Simbulan-Rosenthal CM, Boulares AH, et al. Roles of poly(ADP-ribosyl)ation and PARP in apoptosis, DNA repair, genomic stability and functions of p53 and E2F-1. Adv Enzyme Regul 2000;40:183-215.
24. Schmid G, Wang ZQ, Wesierska-Gadek J. Compensatory expression of p73 in PARP-deficient mouse fibroblasts as response to a reduced level of regularly spliced wild-type p53 protein. Biochem Biophys Res Commun 1999;255:399-405.
25. Kim KC, Jung CS, Choi KH. Overexpression of p73 enhances cisplatin-induced apoptosis in HeLa cells. Arch Pharm Res 2006;29:152-158.
26. Munger K, Basile JR, Duensing S, et al. Biological activities and molecular targets of the human papillomavirus E7 oncoprotein. Oncogene 2001;20:7888-7898.
27. Peeper DS, Upton TM, Ladha MH, et al. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature 1997;386:177-181.
28. Mittnacht S, Paterson H, Olson MF, Marshall CJ. Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein. Curr Biol 1997;7:219-221.
29. Williams JP, Stewart T, Li B, Mulloy R, Dimova D, Classon M. The retinoblastoma protein is required for Ras-induced oncogenic transformation. Mol Cell Biol 2006;26:1170-1182.
30. Palmero I, Serrano M. Induction of senescence by oncogenic Ras. Methods Enzymol 2001;333:247-256.
31. Palmero I, Pantoja C, Serrano M. p19ARF links the tumour suppressor p53 to Ras. Nature 1998;395:125-126.
32. Peeper DS, Dannenberg JH, Douma S, te Riele H, Bernards R. Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat Cell Biol 2001;3:198-203.
33. Sheikh MS, Fornace AJ Jr. Role of p53 family members in apoptosis. J Cell Physiol 2000;182:171-181.
34. Irwin MS, Kaelin WG Jr. Role of the newer p53 family proteins in malignancy. Apoptosis 2001;6:17-29.
35. Tyteca S, Legube G, Trouche D. To die or not to die: A HAT trick. Mol Cell 2006;24:807-808.