Never tear us apart-the importance of centrosome clustering

Journal of Cell Science

Volumn 125, Issue 14, 2012, Pages 3281-3292

  Marthiens, Véronique ^a   Piel, Matthieu ^a   Basto, Renata ^a  

^a CNRS   (France)

Author keywords

Bipolar spindle; Cancer; Centrosome amplification; Chromosome instability; Clustering

Indexed keywords

ANA2 PROTEIN; ASL PROTEIN; CDK5RAP2 PROTEIN; CEP152 PROTEIN; CEP63 PROTEIN; CNN PROTEIN; CP110 PROTEIN; CPAP PROTEIN; PEPTIDES AND PROTEINS; PERICENTRIN; PLK4 PROTEIN; PLP PROTEIN; SAS4 PROTEIN; SAS5 PROTEIN; SAS6 PROTEIN; STIL PROTEIN; UNCLASSIFIED DRUG;

ANEUPLOIDY; BIPOLAR DIVISION; CELL DIVISION; CELL EXPANSION; CENTROSOME; DROSOPHILA; INSECT CELL; INTERPHASE; MITOSIS; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SUPERNUMERARY CHROMOSOME;

ANIMALS; CENTROSOME; DROSOPHILA; HUMANS; MICE; MITOSIS;

EID: 84869143979     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.094797     Document Type: Note

References (153)

1. Arquint, C., Sonnen, K. F., Stierhof, Y. D. and Nigg, E. A. (2012). Cell-cycle- regulated expression of STIL controls centriole number in human cells. J. Cell Sci. 125, 1342-1352.
2. Barr, A. R., Kilmartin, J. V. and Gergely, F. (2010). CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response. J. Cell Biol. 189, 23-39.
3. Barrera, J. A., Kao, L. R., Hammer, R. E., Seemann, J., Fuchs, J. L. and Megraw, T. L. (2010). CDK5RAP2 regulates centriole engagement and cohesion in mice. Dev. Cell 18, 913-926.
4. Basto, R., Lau, J., Vinogradova, T., Gardiol, A., Woods, C. G., Khodjakov, A. and Raff, J. W. (2006). Flies without centrioles. Cell 125, 1375-1386.
5. Basto, R., Brunk, K., Vinadogrova, T., Peel, N., Franz, A., Khodjakov, A. and Raff, J. W. (2008). Centrosome amplification can initiate tumorigenesis in flies. Cell 133, 1032-1042.
6. Bettencourt-Dias, M. and Glover, D. M. (2007). Centrosome biogenesis and function: centrosomics brings new understanding. Nat. Rev. Mol. Cell Biol. 8, 451-463.
7. Bettencourt-Dias, M., Giet, R., Sinka, R., Mazumdar, A., Lock, W. G., Balloux, F., Zafiropoulos, P. J., Yamaguchi, S., Winter, S., Carthew, R. W. et al. (2004). Genome-wide survey of protein kinases required for cell cycle progression. Nature 432, 980-987.
8. Bettencourt-Dias, M., Rodrigues-Martins, A., Carpenter, L., Riparbelli, M., Lehmann, L., Gatt, M. K., Carmo, N., Balloux, F., Callaini, G. and Glover, D. M. (2005). SAK/PLK4 is required for centriole duplication and flagella development. Curr. Biol. 15, 2199-2207.
9. Blachon, S., Gopalakrishnan, J., Omori, Y., Polyanovsky, A., Church, A., Nicastro, D., Malicki, J. and Avidor-Reiss, T. (2008). Drosophila asterless and vertebrate Cep152: Are orthologs essential for centriole duplication. Genetics 180, 2081-2094.
10. Bolhy, S., Bouhlel, I., Dultz, E., Nayak, T., Zuccolo, M., Gatti, X., Vallee, R., Ellenberg, J. and Doye, V. (2011). A Nup133-dependent NPC-anchored network tethers centrosomes to the nuclear envelope in prophase. J. Cell Biol. 192, 855-871.
11. Bond, J., Roberts, E., Springell, K., Lizarraga, S. B., Scott, S., Higgins, J., Hampshire, D. J., Morrison, E. E., Leal, G. F., Silva, E. O. et al. (2005). A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nat. Genet. 37, 353-355.
12. Bornens, M. (2002). Centrosome composition and microtubule anchoring mechanisms. Curr. Opin. Cell Biol. 14, 25-34.
13. Boveri, T. (2008). Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris. J. Cell Sci. 121 Suppl. 1, 1-84.
14. Brinkley, B. R. and Goepfert, T. M. (1998). Supernumerary centrosomes and cancer: Boveri's hypothesis resurrected. Cell Motil. Cytoskeleton 41, 281-288.
15. Brinkley, B. R., Cox, S. M., Pepper, D. A., Wible, L., Brenner, S. L. and Pardue, R. L. (1981). Tubulin assembly sites and the organization of cytoplasmic microtubules in cultured mammalian cells. J. Cell Biol. 90, 554-562.
16. Brownlee, C. W., Klebba, J. E., Buster, D. W. and Rogers, G. C. (2011). The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. J. Cell Biol. 195, 231-243.
17. Buchman, J. J., Tseng, H. C., Zhou, Y., Frank, C. L., Xie, Z. and Tsai, L. H. (2010). Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron 66, 386-402.
18. Buffin, E., Emre, D. and Karess, R. E. (2007). Flies without a spindle checkpoint. Nat. Cell Biol. 9, 565-572.
19. Burbank, K. S., Mitchison, T. J. and Fisher, D. S. (2007). Slide-and-cluster models for spindle assembly. Curr. Biol. 17, 1373-1383.
20. Carreno, S., Kouranti, I., Glusman, E. S., Fuller, M. T., Echard, A. and Payre, F. (2008). Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells. J. Cell Biol. 180, 739-746.
21. Castellanos, E., Dominguez, P. and Gonzalez, C. (2008). Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr. Biol. 18, 1209-1214.
22. Caussinus, E. and Gonzalez, C. (2005). Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat. Genet. 37, 1125-1129.
23. Chen, Z., Indjeian, V. B., McManus, M., Wang, L. and Dynlacht, B. D. (2002). CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells. Dev. Cell 3, 339-350.
24. Cimini, D., Howell, B., Maddox, P., Khodjakov, A., Degrassi, F. and Salmon, E. D. (2001). Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J. Cell Biol. 153, 517-527.
25. Cizmecioglu, O., Arnold, M., Bahtz, R., Settele, F., Ehret, L., Haselmann-Weiss, U., Antony, C. and Hoffmann, I. (2010). Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. J. Cell Biol. 191, 731-739.
26. Cullen, C. F. and Ohkura, H. (2001). Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles. Nat. Cell Biol. 3, 637-642.
27. Cunha-Ferreira, I., Rodrigues-Martins, A., Bento, I., Riparbelli, M., Zhang, W., Laue, E., Callaini, G., Glover, D. M. and Bettencourt-Dias, M. (2009). The SCF/ Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/ PLK4. Curr. Biol. 19, 43-49.
28. D'Angiolella, V., Donato, V., Vijayakumar, S., Saraf, A., Florens, L., Washburn, M. P., Dynlacht, B. and Pagano, M. (2010). SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation. Nature 466, 138-142.
29. Delattre, M. and Gönczy, P. (2004). The arithmetic of centrosome biogenesis. J. Cell Sci. 117, 1619-1630.
30. Delattre, M., Leidel, S., Wani, K., Baumer, K., Bamat, J., Schnabel, H., Feichtinger, R., Schnabel, R. and Gönczy, P. (2004). Centriolar SAS-5 is required for centrosome duplication in C. elegans. Nat. Cell Biol. 6, 656-664.
31. Delattre, M., Canard, C. and Gönczy, P. (2006). Sequential protein recruitment in C. elegans centriole formation. Curr. Biol. 16, 1844-1849.
32. Dobbelaere, J., Josué, F., Suijkerbuijk, S., Baum, B., Tapon, N. and Raff, J. (2008). A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila. PLoS Biol. 6, e224.
33. Doxsey, S. (2002). Duplicating dangerously: linking centrosome duplication and aneuploidy. Mol. Cell 10, 439-440.
34. Duncan, A. W., Taylor, M. H., Hickey, R. D., Hanlon Newell, A. E., Lenzi, M. L., Olson, S. B., Finegold, M. J. and Grompe, M. (2010). The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature 467, 707-710.
35. Dzhindzhev, N. S., Yu, Q. D., Weiskopf, K., Tzolovsky, G., Cunha-Ferreira, I., Riparbelli, M., Rodrigues-Martins, A., Bettencourt-Dias, M., Callaini, G. and Glover, D. M. (2010). Asterless is a scaffold for the onset of centriole assembly. Nature 467, 714-718.
36. Endow, S. A. and Komma, D. J. (1998). Assembly and dynamics of an anastral:astral spindle: the meiosis II spindle of Drosophila oocytes. J. Cell Sci. 111, 2487-2495.
37. Fache, V., Gaillard, J., Van Damme, D., Geelen, D., Neumann, E., Stoppin-Mellet, V. and Vantard, M. (2010). Arabidopsis kinetochore fiber-associated MAP65-4 cross-links microtubules and promotes microtubule bundle elongation. Plant Cell 22, 3804-3815.
38. Faggioli, F., Vezzoni, P. and Montagna, C. (2011). Single-cell analysis of ploidy and centrosomes underscores the peculiarity of normal hepatocytes. PLoS ONE 6, e26080.
39. Fant, X., Srsen, V., Espigat-Georger, A. and Merdes, A. (2009). Nuclei of non-muscle cells bind centrosome proteins upon fusion with differentiating myoblasts. PLoS ONE 4, e8303.
40. Fink, J., Carpi, N., Betz, T., Bétard, A., Chebah, M., Azioune, A., Bornens, M., Sykes, C., Fetler, L., Cuvelier, D. et al. (2011). External forces control mitotic spindle positioning. Nat. Cell Biol. 13, 771-778.
41. Fujiwara, T., Bandi, M., Nitta, M., Ivanova, E. V., Bronson, R. T. and Pellman, D. (2005). Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437, 1043-1047.
42. Gaillard, J., Neumann, E., Van Damme, D., Stoppin-Mellet, V., Ebel, C., Barbier, E., Geelen, D. and Vantard, M. (2008). Two microtubule-associated proteins of Arabidopsis MAP65s promote antiparallel microtubule bundling. Mol. Biol. Cell 19, 4534-4544.
43. Ganem, N. J., Godinho, S. A. and Pellman, D. (2009). A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282.
44. Getsios, S. and MacCalman, C. D. (2003). Cadherin-11 modulates the terminal differentiation and fusion of human trophoblastic cells in vitro. Dev. Biol. 257, 41-54.
45. Gonzalez, C. (2007). Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat. Rev. Genet. 8, 462-472.
46. Gonzalez, C. (2008). Centrosome function during stem cell division: the devil is in the details. Curr. Opin. Cell Biol. 20, 694-698.
47. Goshima, G., Wollman, R., Goodwin, S. S., Zhang, N., Scholey, J. M., Vale, R. D. and Stuurman, N. (2007). Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316, 417-421.
48. Grava, S., Schaerer, F., Faty, M., Philippsen, P. and Barral, Y. (2006). Asymmetric recruitment of dynein to spindle poles and microtubules promotes proper spindle orientation in yeast. Dev. Cell 10, 425-439.
49. Guderian, G., Westendorf, J., Uldschmid, A. and Nigg, E. A. (2010). Plk4 trans- autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation. J. Cell Sci. 123, 2163-2169.
50. Guernsey, D. L., Jiang, H., Hussin, J., Arnold, M., Bouyakdan, K., Perry, S., Babineau-Sturk, T., Beis, J., Dumas, N., Evans, S. C. et al. (2010). Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. Am. J. Hum. Genet. 87, 40-51.
51. Guidotti, J. E., Brégerie, O., Robert, A., Debey, P., Brechot, C. and Desdouets, C. (2003). Liver cell polyploidization: a pivotal role for binuclear hepatocytes. J. Biol. Chem. 278, 19095-19101.
52. Guo, H. Q., Gao, M., Ma, J., Xiao, T., Zhao, L. L., Gao, Y. and Pan, Q. J. (2007). Analysis of the cellular centrosome in fine-needle aspirations of the breast. Breast Cancer Res. 9, R48.
53. Habedanck, R., Stierhof, Y. D., Wilkinson, C. J. and Nigg, E. A. (2005). The Polo kinase Plk4 functions in centriole duplication. Nat. Cell Biol. 7, 1140-1146.
54. Hatch, E. M., Kulukian, A., Holland, A. J., Cleveland, D. W. and Stearns, T. (2010). Cep152 interacts with Plk4 and is required for centriole duplication. J. Cell Biol. 191, 721-729.
55. Heald, R., Tournebize, R., Blank, T., Sandaltzopoulos, R., Becker, P., Hyman, A. and Karsenti, E. (1996). Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature 382, 420-425.
56. Herwig, L., Blum, Y., Krudewig, A., Ellertsdottir, E., Lenard, A., Belting, H. G. and Affolter, M. (2011). Distinct cellular mechanisms of blood vessel fusion in the zebrafish embryo. Curr. Biol. 21, 1942-1948.
57. Holland, A. J., Lan, W., Niessen, S., Hoover, H. and Cleveland, D. W. (2010). Polo like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability. J. Cell Biol. 188, 191-198.
58. Janson, M. E., Loughlin, R., Loïodice, I., Fu, C., Brunner, D., Nédélec, F. J. and Tran, P. T. (2007). Crosslinkers and motors organize dynamic microtubules to form stable bipolar arrays in fission yeast. Cell 128, 357-368.
59. Jurczyk, A., Gromley, A., Redick, S., San Agustin, J., Witman, G., Pazour, G. J., Peters, D. J. and Doxsey, S. (2004). Pericentrin forms a complex with intraflagellar transport proteins and polycystin-2 and is required for primary cilia assembly. J. Cell Biol. 166, 637-643.
60. Kemp, C. A., Kopish, K. R., Zipperlen, P., Ahringer, J. and O'Connell, K. F. (2004). Centrosome maturation and duplication in C. elegans require the coiled-coil protein SPD-2. Dev. Cell 6, 511-523.
61. Khodjakov, A. and Rieder, C. L. (2001). Centrosomes enhance the fidelity of cytokinesis in vertebrates and are required for cell cycle progression. J. Cell Biol. 153, 237-242.
62. Khodjakov, A., Cole, R. W., Oakley, B. R. and Rieder, C. L. (2000). Centrosome independent mitotic spindle formation in vertebrates. Curr. Biol. 10, 59-67.
63. Kingsbury, M. A., Friedman, B., McConnell, M. J., Rehen, S. K., Yang, A. H., Kaushal, D. and Chun, J. (2005). Aneuploid neurons are functionally active and integrated into brain circuitry. Proc. Natl. Acad. Sci. USA 102, 6143-6147.
64. Kirkham, M., Müller-Reichert, T., Oegema, K., Grill, S. and Hyman, A. A. (2003). SAS-4 is a C. elegans centriolar protein that controls centrosome size. Cell 112, 575-587.
65. Kitagawa, D., Busso, C., Flückiger, I. and Gönczy, P. (2009). Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos. Dev. Cell 17, 900-907.
66. Kitagawa, D., Vakonakis, I., Olieric, N., Hilbert, M., Keller, D., Olieric, V., Bortfeld, M., Erat, M. C., Flückiger, I., Gönczy, P. et al. (2011). Structural basis of the 9-fold symmetry of centrioles. Cell 144, 364-375.
67. Kitajima, T. S., Ohsugi, M. and Ellenberg, J. (2011). Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes. Cell 146, 568-581.
68. Kleylein-Sohn, J., Westendorf, J., Le Clech, M., Habedanck, R., Stierhof, Y. D. and Nigg, E. A. (2007). Plk4-induced centriole biogenesis in human cells. Dev. Cell 13, 190-202.
69. Knoblich, J. A. (2008). Mechanisms of asymmetric stem cell division. Cell 132, 583-597.
70. Kobayashi, T. and Dynlacht, B. D. (2011). Regulating the transition from centriole to basal body. J. Cell Biol. 193, 435-444.
71. Kohlmaier, G., Loncarek, J., Meng, X., McEwen, B. F., Mogensen, M. M., Spektor, A., Dynlacht, B. D., Khodjakov, A. and Gönczy, P. (2009). Overly long centrioles and defective cell division upon excess of the SAS-4-related protein CPAP. Curr. Biol. 19, 1012-1018.
72. Korzeniewski, N., Treat, B. and Duensing, S. (2011). The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression. Mol. Cancer 10, 61.
73. Krzywicka-Racka, A. and Sluder, G. (2011). Repeated cleavage failure does not establish centrosome amplification in untransformed human cells. J. Cell Biol. 194, 199-207.
74. Kumar, A., Girimaji, S. C., Duvvari, M. R. and Blanton, S. H. (2009). Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly. Am. J. Hum. Genet. 84, 286-290.
75. Kunda, P., Pelling, A. E., Liu, T. and Baum, B. (2008). Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr. Biol. 18, 91- 101.
76. Kuriyama, R. and Borisy, G. G. (1981). Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy. J. Cell Biol. 91, 814-821.
77. Kwon, M., Godinho, S. A., Chandhok, N. S., Ganem, N. J., Azioune, A., Thery, M. and Pellman, D. (2008). Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 22, 2189-2203.
78. Leber, B., Maier, B., Fuchs, F., Chi, J., Riffel, P., Anderhub, S., Wagner, L., Ho, A. D., Salisbury, J. L., Boutros, M. et al. (2010). Proteins required for centrosome clustering in cancer cells. Sci. Transl. Med. 2, 33ra38.
79. Leidel, S. and Gönczy, P. (2003). SAS-4 is essential for centrosome duplication in C elegans and is recruited to daughter centrioles once per cell cycle. Dev. Cell 4, 431- 439.
80. Leidel, S., Delattre, M., Cerutti, L., Baumer, K. and Gönczy, P. (2005). SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat. Cell Biol. 7, 115-125.
81. Lingle, W. L. and Salisbury, J. L. (1999). Altered centrosome structure is associated with abnormal mitoses in human breast tumors. Am. J. Pathol. 155, 1941-1951.
82. Lingle, W. L. and Salisbury, J. L. (2000). The role of the centrosome in the development of malignant tumors. Curr. Top. Dev. Biol. 49, 313-329.
83. Loughlin, R., Heald, R. and Nédélec, F. (2010). A computational model predicts Xenopus meiotic spindle organization. J. Cell Biol. 191, 1239-1249.
84. Loughlin, R., Wilbur, J. D., McNally, F. J., Nédélec, F. J. and Heald, R. (2011). Katanin contributes to interspecies spindle length scaling in Xenopus. Cell 147, 1397- 1407.
85. Lucas, E. P. and Raff, J. W. (2007). Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin. J. Cell Biol. 178, 725-732.
86. Magidson, V., O'Connell, C. B., Lončarek, J., Paul, R., Mogilner, A. and Khodjakov, A. (2011). The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly. Cell 146, 555-567.
87. Margall-Ducos, G., Celton-Morizur, S., Couton, D., Brégerie, O. and Desdouets, C. (2007). Liver tetraploidization is controlled by a new process of incomplete cytokinesis. J. Cell Sci. 120, 3633-3639.
88. Martinez-Campos, M., Basto, R., Baker, J., Kernan, M. and Raff, J. W. (2004). The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis. J. Cell Biol. 165, 673-683.
89. Megraw, T. L., Kao, L. R. and Kaufman, T. C. (2001). Zygotic development without functional mitotic centrosomes. Curr. Biol. 11, 116-120.
90. Minc, N., Burgess, D. and Chang, F. (2011). Influence of cell geometry on division- plane positioning. Cell 144, 414-426.
91. Morin, X. and Bellaïche, Y. (2011). Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development. Dev. Cell 21, 102-119.
92. Morin, X., Daneman, R., Zavortink, M. and Chia, W. (2001). A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Proc. Natl. Acad. Sci. USA 98, 15050-15055.
93. Murphy, T. D. (2003). Drosophila skpA, a component of SCF ubiquitin ligases, regulates centrosome duplication independently of cyclin E accumulation. J. Cell Sci. 116, 2321-2332.
94. Musacchio, A. and Salmon, E. D. (2007). The spindle-assembly checkpoint in space and time. Nat. Rev. Mol. Cell Biol. 8, 379-393.
95. Nédélec, F. J., Surrey, T., Maggs, A. C. and Leibler, S. (1997). Self-organization of microtubules and motors. Nature 389, 305-308.
96. Nigg, E. A. (2006). Origins and consequences of centrosome aberrations in human cancers. Int. J. Cancer 119, 2717-2723.
97. Nigg, E. A. and Raff, J. W. (2009). Centrioles, centrosomes, and cilia in health and disease. Cell 139, 663-678.
98. O'Connell, K. F. (2002). The ZYG-1 kinase, a mitotic and meiotic regulator of centriole replication. Oncogene 21, 6201-6208.
99. O'Connell, K. F., Maxwell, K. N. and White, J. G. (2000). The spd-2 gene is required for polarization of the anteroposterior axis and formation of the sperm asters in the Caenorhabditis elegans zygote. Dev. Biol. 222, 55-70.
100. Otto, S. P. (2007). The evolutionary consequences of polyploidy. Cell 131, 452-462.
101. Peel, N., Stevens, N. R., Basto, R. and Raff, J. W. (2007). Overexpressing centriole- replication proteins in vivo induces centriole overduplication and de novo formation. Curr. Biol. 17, 834-843.
102. Pelletier, L., Ozlü, N., Hannak, E., Cowan, C., Habermann, B., Ruer, M., Müller-Reichert, T. and Hyman, A. A. (2004). The Caenorhabditis elegans centrosomal protein SPD-2 is required for both pericentriolar material recruitment and centriole duplication. Curr. Biol. 14, 863-873.
103. Pelletier, L., O'Toole, E., Schwager, A., Hyman, A. A. and Müller-Reichert, T. (2006). Centriole assembly in Caenorhabditis elegans. Nature 444, 619-623.
104. Puklowski, A., Homsi, Y., Keller, D., May, M., Chauhan, S., Kossatz, U., Grünwald, V., Kubicka, S., Pich, A., Manns, M. P. et al. (2011). The SCF-FBXW5 E3- ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat. Cell Biol. 13, 1004-1009.
105. Quintyne, N. J., Reing, J. E., Hoffelder, D. R., Gollin, S. M. and Saunders, W. S. (2005). Spindle multipolarity is prevented by centrosomal clustering. Science 307, 127-129.
106. Rauch, A., Thiel, C. T., Schindler, D., Wick, U., Crow, Y. J., Ekici, A. B., van Essen, A. J., Goecke, T. O., Al-Gazali, L., Chrzanowska, K. H. et al. (2008). Mutations in the pericentrin (PCNT) gene cause primordial dwarfism. Science 319, 816-819.
107. Rebollo, E., Sampaio, P., Januschke, J., Llamazares, S., Varmark, H. and González, C. (2007). Functionally unequal centrosomes drive spindle orientation in asymme- trically dividing Drosophila neural stem cells. Dev. Cell 12, 467-474.
108. Ring, D., Hubble, R. and Kirschner, M. (1982). Mitosis in a cell with multiple centrioles. J. Cell Biol. 94, 549-556.
109. Rodionov, V. I. and Borisy, G. G. (1997). Self-centring activity of cytoplasm. Nature 386, 170-173.
110. Rodrigues-Martins, A., Riparbelli, M., Callaini, G., Glover, D. M. and Bettencourt-Dias, M. (2007). Revisiting the role of the mother centriole in centriole biogenesis. Science 316, 1046-1050.
111. Rodrigues-Martins, A., Bettencourt-Dias, M., Riparbelli, M., Ferreira, C., Ferreira, I., Callaini, G. and Glover, D. M. (2007). DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly. Curr. Biol. 17, 1465-1472.
112. Rogers, G. C., Rusan, N. M., Roberts, D. M., Peifer, M. and Rogers, S. L. (2009). The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication. J. Cell Biol. 184, 225-239.
113. Rusan, N. M. and Rogers, G. C. (2009). Centrosome function: sometimes less is more. Traffic 10, 472-481.
114. Schmidt, T. I., Kleylein-Sohn, J., Westendorf, J., Le Clech, M., Lavoie, S. B., Stierhof, Y. D. and Nigg, E. A. (2009). Control of centriole length by CPAP and CP110. Curr. Biol. 19, 1005-1011.
115. Schuh, M. and Ellenberg, J. (2007). Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes. Cell 130, 484- 498.
116. Silkworth, W. T., Nardi, I. K., Scholl, L. M. and Cimini, D. (2009). Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells. PLoS ONE 4, e6564.
117. Sillibourne, J. E., Tack, F., Vloemans, N., Boeckx, A., Thambirajah, S., Bonnet, P., Ramaekers, F. C., Bornens, M. and Grand-Perret, T. (2010). Autophosphorylation of polo-like kinase 4 and its role in centriole duplication. Mol. Biol. Cell 21, 547-561.
118. Sir, J. H., Barr, A. R., Nicholas, A. K., Carvalho, O. P., Khurshid, M., Sossick, A., Reichelt, S., D'Santos, C., Woods, C. G. and Gergely, F. (2011). A primary microcephaly protein complex forms a ring around parental centrioles. Nat. Genet. 43, 1147-1153.
119. Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W. and Benezra, R. (2007). Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11, 9-23.
120. Sotillo, R., Schvartzman, J. M., Socci, N. D. and Benezra, R. (2010). Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal. Nature 464, 436-440.
121. Spektor, A., Tsang, W. Y., Khoo, D. and Dynlacht, B. D. (2007). Cep97 and CP110 suppress a cilia assembly program. Cell 130, 678-690.
122. Splinter, D., Tanenbaum, M. E., Lindqvist, A., Jaarsma, D., Flotho, A., Yu, K. L., Grigoriev, I., Engelsma, D., Haasdijk, E. D., Keijzer, N. et al. (2010). Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry. PLoS Biol. 8, e1000350.
123. Srinivas, B. P., Woo, J., Leong, W. Y. and Roy, S. (2007). A conserved molecular pathway mediates myoblast fusion in insects and vertebrates. Nat. Genet. 39, 781-786.
124. Stevens, N. R., Dobbelaere, J., Brunk, K., Franz, A. and Raff, J. W. (2010). Drosophila Ana2 is a conserved centriole duplication factor. J. Cell Biol. 188, 313- 323.
125. Storchova, Z. and Pellman, D. (2004). From polyploidy to aneuploidy, genome instability and cancer. Nat. Rev. Mol. Cell Biol. 5, 45-54.
126. Strnad, P., Leidel, S., Vinogradova, T., Euteneuer, U., Khodjakov, A. and Gönczy, P. (2007). Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle. Dev. Cell 13, 203-213.
127. Subramanian, R., Wilson-Kubalek, E. M., Arthur, C. P., Bick, M. J., Campbell, E. A., Darst, S. A., Milligan, R. A. and Kapoor, T. M. (2010). Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein. Cell 142, 433-443.
128. Surrey, T., Nedelec, F., Leibler, S. and Karsenti, E. (2001). Physical properties determining self-organization of motors and microtubules. Science 292, 1167-1171.
129. Sussan, T. E., Yang, A., Li, F., Ostrowski, M. C. and Reeves, R. H. (2008). Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature 451, 73-75.
130. Tanenbaum, M. E. and Medema, R. H. (2010). Mechanisms of centrosome separation and bipolar spindle assembly. Dev. Cell 19, 797-806.
131. Tanenbaum, M. E., Macùrek, L., Galjart, N. and Medema, R. H. (2008). Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly. EMBO J. 27, 3235-3245.
132. Tanenbaum, M. E., Macùrek, L., Janssen, A., Geers, E. F., Alvarez-Fernández, M. and Medema, R. H. (2009). Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr. Biol. 19, 1703-1711.
133. Tang, C. J., Fu, R. H., Wu, K. S., Hsu, W. B. and Tang, T. K. (2009). CPAP is a cell- cycle regulated protein that controls centriole length. Nat. Cell Biol. 11, 825-831.
134. Tang, C. J., Lin, S. Y., Hsu, W. B., Lin, Y. N., Wu, C. T., Lin, Y. C., Chang, C. W., Wu, K. S. and Tang, T. K. (2011). The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO J. 30, 4790-4804.
135. Tassin, A. M., Maro, B. and Bornens, M. (1985). Fate of microtubule-organizing centers during myogenesis in vitro. J. Cell Biol. 100, 35-46.
136. Théry, M., Racine, V., Pépin, A., Piel, M., Chen, Y., Sibarita, J. B. and Bornens, M. (2005). The extracellular matrix guides the orientation of the cell division axis. Nat. Cell Biol. 7, 947-953.
137. Théry, M., Jiménez-Dalmaroni, A., Racine, V., Bornens, M. and Jülicher, F. (2007). Experimental and theoretical study of mitotic spindle orientation. Nature 447, 493- 496.
138. Thompson, S. L. and Compton, D. A. (2008). Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell Biol. 180, 665-672.
139. Thompson, S. L. and Compton, D. A. (2010). Proliferation of aneuploid human cells is limited by a p53-dependent mechanism. J. Cell Biol. 188, 369-381.
140. Thompson, S. L. and Compton, D. A. (2011). Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors. Proc. Natl. Acad. Sci. USA 108, 17974-17978.
141. Thornton, G. K. and Woods, C. G. (2009). Primary microcephaly: do all roads lead to Rome. Trends Genet. 25, 501-510.
142. Uetake, Y. and Sluder, G. (2004). Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a tetraploidy checkpoint. J. Cell Biol. 165, 609-615.
143. Unhavaithaya, Y. and Orr-Weaver, T. L. (2012). Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity. Genes Dev. 26, 31-36.
144. van Breugel, M., Hirono, M., Andreeva, A., Yanagisawa, H. A., Yamaguchi, S., Nakazawa, Y., Morgner, N., Petrovich, M., Ebong, I. O., Robinson, C. V. et al. (2011). Structures of SAS-6 suggest its organization in centrioles. Science 331, 1196-1199.
145. Varmark, H., Llamazares, S., Rebollo, E., Lange, B., Reina, J., Schwarz, H. and Gonzalez, C. (2007). Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila. Curr. Biol. 17, 1735-1745.
146. Vulprecht, J., David, A., Tibelius, A., Castiel, A., Konotop, G., Liu, F., Bestvater, F., Raab, M. S., Zentgraf, H., Izraeli, S. et al. (2012). STIL is required for centriole duplication in human cells. J. Cell Sci. 125, 1353-1362.
147. Weaver, B. A. and Cleveland, D. W. (2009). The role of aneuploidy in promoting and suppressing tumors. J. Cell Biol. 185, 935-937.
148. Weaver, B. A., Silk, A. D., Montagna, C., Verdier-Pinard, P. and Cleveland, D. W. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11, 25-36.
149. Williams, B. R., Prabhu, V. R., Hunter, K. E., Glazier, C. M., Whittaker, C. A., Housman, D. E. and Amon, A. (2008). Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science 322, 703-709.
150. Wojcik, E. J., Glover, D. M. and Hays, T. S. (2000). The SCF ubiquitin ligase protein slimb regulates centrosome duplication in Drosophila. Curr. Biol. 10, 1131-1134.
151. Yang, A. H., Kaushal, D., Rehen, S. K., Kriedt, K., Kingsbury, M. A., McConnell, M. J. and Chun, J. (2003). Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J. Neurosci. 23, 10454-10462.
152. Zimmerman, W. C., Sillibourne, J., Rosa, J. and Doxsey, S. J. (2004). Mitosis- specific anchoring of gamma tubulin complexes by pericentrin controls spindle organization and mitotic entry. Mol. Biol. Cell 15, 3642-3657.
153. Zyss, D. and Gergely, F. (2009). Centrosome function in cancer: guilty or innocent. Trends Cell Biol. 19, 334-346.