Centrosome function during stem cell division: the devil is in the details

Current Opinion in Cell Biology

Volumn 20, Issue 6, 2008, Pages 694-698

  Gonzalez, Cayetano ^a,b  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^b INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL DIVISION; CELL POLARITY; CELL RENEWAL; CENTROSOME; DROSOPHILA; GERM LINE; HUMAN; NEURAL STEM CELL; NEUROBLAST; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; STEM CELL;

ANIMALS; CELL DIVISION; CELL POLARITY; CENTROSOME; DROSOPHILA; FEMALE; GERM CELLS; HUMANS; MALE; MICROTUBULES; MODELS, BIOLOGICAL; STEM CELLS;

ANIMALIA;

EID: 56949084012     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2008.10.003     Document Type: Review

References (42)

1. Basto R., Lau J., Vinogradova T., Gardiol A., Woods C.G., Khodjakov A., and Raff J.W. Flies without centrioles. Cell 125 (2006) 1375-1386. This is the first report of adult flies homozygous for a mutant that causes the loss of centrioles during zygotic development.
2. Stevens N.R., Raposo A.A.S.F., Basto R., St Johnston D., and Raff J.W. From stem cell to embryo without centrioles. Curr Biol 17 (2007) 1498-1503. This article demonstrates that acentriolar fGSCs can undergo asymmetric division, renewing themselves and producing daughters that differentiate into fully mature eggs.
3. Varmark H., Llamazares S., Rebollo E., Lange B., Reina J., Schwarz H., and Gonzalez C. Asterless is a centriolar protein required for centrosome function and embryo development in Drosophila. Curr Biol 17 (2007) 1735-1745
4. Rodrigues-Martins A., Riparbelli M., Callaini G., Glover D.M., and Bettencourt-Dias M. From centriole biogenesis to cellular function: centrioles are essential for cell division at critical developmental stages. Cell Cycle 7 (2008) 11-16
5. Gatti M., and Goldberg M.L. Mutations affecting cell division in Drosophila. Methods Cell Biol 35 (1991) 543-586
6. Spieth H.T. Drosophilid mating behavior: the behaviour of decapitated females. Anim Behav 14 (1966) 226-235
7. Szabad J., and Fajszi C. Control of female reproduction in Drosophila: genetic dissection using gynandromorphs. Genetics 100 (1982) 61-78
8. Doe C.Q. Neural stem cells: balancing self-renewal with differentiation. Development 135 (2008) 1575-1587
9. Knoblich J.A. Mechanisms of asymmetric stem cell division. Cell 132 (2008) 583-597
10. Bowman S.K., Neumuller R.A., Novatchkova M., Du Q., and Knoblich J.A. The Drosophila NuMA homolog Mud regulates spindle orientation in asymmetric cell division. Dev Cell 10 (2006) 731-742. This and the following two references identified Mud as a key regulator of spindle orientation in Drosophila neuroblasts.
11. Siller K.H., Cabernard C., and Doe C.Q. The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nat Cell Biol 8 (2006) 594-600. See above.
12. Izumi Y., Ohta N., Hisata K., Raabe T., and Matsuzaki F. Drosophila Pins-binding protein Mud regulates spindle-polarity coupling and centrosome organization. Nat Cell Biol 8 (2006) 586-593. See above.
13. Siegrist S.E., and Doe C.Q. Microtubule-induced Pins/G [alpha]i cortical polarity in Drosophila neuroblasts. Cell 123 (2005) 1323-1335. Describes the role of microtubules in cortical polarity.
14. Siegrist S.E., and Doe C.Q. Microtubule-induced cortical cell polarity. Genes Dev 21 (2007) 483-496
15. Rebollo E. Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. Dev Cell 12 (2007) 467-474. This and the following reference showed that the two centrosomes of an NB are unequal in function and fate and contribute to align the spindle with the polarity axis in these cells.
16. Rusan N.M., and Peifer M. A role for a novel centrosome cycle in asymmetric cell division. J Cell Biol 177 (2007) 13-20. See above.
17. Gonzalez C. Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat Rev Genet 8 (2007) 462-472
18. Megraw T.L., Li K., Kao L.R., and Kaufman T.C. The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila. Development 126 (1999) 2829-2839
19. Vaizel-Ohayon D., and Schejter E.D. Mutations in centrosomin reveal requirements for centrosomal function during early Drosophila embryogenesis. Curr Biol 9 (1999) 889-898
20. Bonaccorsi S., Giansanti M.G., and Gatti M. Spindle self-organization and cytokinesis during male meiosis in asterless mutants of Drosophila melanogaster. J Cell Biol 142 (1998) 751-761
21. Megraw T.L., Kao L.-R., and Kaufman T.C. Zygotic development without functional mitotic centrosomes. Curr Biol 11 (2001) 116-120. This is the first report of adult flies homozygous for a mutant that causes centrosome dysfunction during zygotic development.
22. Lee C.Y. Drosophila Aurora-A-kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev 20 (2006) 3464-3474
23. Giansanti M.G., Gatti M., and Bonaccorsi S. The role of centrosomes and astral microtubules during asymmetric division of Drosophila neuroblasts. Development 128 (2001) 1137-1145. One of the first demonstrations on the role of centrosomes in neuroblast asymmetric division.
24. Castellanos E., Dominguez P., and Gonzalez C. Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol 18 (2008) 1209-1214. This article showed that different types of centrosome dysfunction, including centrosome loss by mutation, in dsas4 are tumorigenic in larval NBs.
25. Basto R., Brunk K., Vinadogrova T., Peel N., Franz A., Khodjakov A., and Raff J.W. Centrosome amplification can initiate tumorigenesis in flies. Cell 133 (2008) 1032-1042
26. de Anda F.C., Pollarolo G., Da Silva J.S., Camoletto P.G., Feiguin F., and Dotti C.G. Centrosome localization determines neuronal polarity. Nature 436 (2005) 704-708
27. Morrison S.J., and Spradling A.C. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 132 (2008) 598-611
28. Fuller M.T., and Spradling A.C. Male and female Drosophila germline stem cells: two versions of immortality. Science 316 (2007) 402-404
29. Yamashita Y.M., Mahowald A.P., Perlin J.R., and Fuller M.T. Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science 315 (2007) 518-521. This article showed that centrosomes in mGSCs are unequal in function and fate and that the oldest centrosome is retained by the mGSC at each division.
30. Yamashita Y.M., Jones D.L., and Fuller M.T. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 301 (2003) 1547-1550. This article showed that spindle alignment in mGSCs is mediated by APC and astral microtubules. It also showed that centrosome dysfunction can result in spindle misorientation and expansion of the SC compartment.
31. Deng W., and Lin H. Spectrosomes and Fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. Dev Biol 189 (1997) 79-94
32. Lin H., and Spradling A.C. A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 124 (1997) 2463-2476
33. Cooley L., and Theurkauf W.E. Cytoskeletal functions during Drosophila oogenesis. Science 266 (1994) 590-596
34. Doubilet S., and McKim K.S. Spindle assembly in the oocytes of mouse and Drosophila-similar solutions to a problem. Chromosome Res 15 (2007) 681-696
35. Cowan C.R., and Hyman A.A. Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos. Nature 431 (2004) 92-96. This, and the following article describe the role of microtubules and centrosomes in axis formation in C. elegans.
36. Tsai M.-C., and Ahringer J. Microtubules are involved in anterior-posterior axis formation in C. elegans embryos. J Cell Biol 179 (2007) 397-402. See above.
37. Kuang S., Kuroda K., Le Grand F., and Rudnicki M.A. Asymmetric self-renewal and commitment of satellite stem cells in muscle. Cell 129 (2007) 999-1010. Describes the role of microtubules in satellite stem cell asymmetric division.
38. Schroeder T. Asymmetric cell division in normal and malignant hematopoietic precursor cells. Cell Stem Cell 1 (2007) 479-481
39. Yingling J., Youn Y.H., Darling D., Toyo-Oka K., Pramparo T., Hirotsune S., and Wynshaw-Boris A. Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell 132 (2008) 474-486
40. Wu M., Kwon H.Y., Rattis F., Blum J., Zhao C., Ashkenazi R., Jackson T.L., Gaiano N., Oliver T., and Reya T. Imaging hematopoietic precursor division in real time. Cell Stem Cell 1 (2007) 541-554. Using live imaging techniques, these authors showed that haematopoietic precursors can divide asymmetrically or symmetrically, depending on extrinsic cues from the environment and on intrinsic cues like oncogenes.
41. Higginbotham H.R., and Gleeson J.G. The centrosome in neuronal development. Trends Neurosci 30 (2007) 276-283
42. Stearns T., and Winey M. The cell center at 100. Cell 91 (1997) 303-309