GDNF and BDNF gene interplay in chronic tinnitus

International Journal of Molecular Epidemiology and Genetics

Volumn 3, Issue 3, 2012, Pages 245-251

  Sand, P G ^a   Langguth, B ^a   Schecklmann, M ^a   Kleinjung, T ^a,b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

BDNF; GDNF; Genetic variation; Sexual dimorphism; Tinnitus

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR;

ADULT; ALLELE; ARTICLE; CAUCASIAN; CHRONIC DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NERVE CELL PLASTICITY; SEX DIFFERENCE; TINNITUS;

EID: 84869120251     PISSN: None     EISSN: 19481756     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Shargorodsky J, Curhan GC, Farwell WR. Prevalence and characteristics of tinnitus among US adults. Am J Med 2010; 123: 711-718.
2. Ortmann AJ, Neely JG. Sudden sensorineural hearing loss and delayed complete sudden spontaneous recovery. J Am Acad Audiol 2012; 23: 249-255.
3. Deshaies P, Gonzales Z, Zenner HP, Plontke S, Paré L, Hébert S, Normandin N, Girard SA, Leroux T, Tyler R, Côté C. Environmental Noise and Tinnitus. In: Burden of disease from environmental noise. Quantification of healthy life years lost in Europe. Edited by Theakston F. WHO, Copenhagen 2011; pp: 71-90
4. Sand PG, Langguth B, Kleinjung T, Eichhammer P. Genetics of chronic tinnitus. Prog Brain Res 2007; 166: 159-168.
5. Petersen HC, Andersen T, Frederiksen H, Hoffman HJ, Christensen K. The heritability of tinnitus: a twin study. Poster presented at: Nordic Epidemiology Congress; June 9-12, 2002. Aarhus, Denmark.
6. Kvestad E, Czajkowski N, Engdahl B, Hoffman HJ, Tambs K. Low heritability of tinnitus: results from the second Nord-Trøndelag health study. Arch Otolaryngol Head Neck Surg 2010; 136: 178-182.
7. Saunders JC. The role of central nervous system plasticity in tinnitus. J Commun Disord 2007; 40: 313-334.
8. Tzounopoulos T. Mechanisms of synaptic plasticity in the dorsal cochlear nucleus: plasticity-induced changes that could underlie tinnitus. Am J Audiol 2008; 17: S170-175.
9. Møller AR. Plasticity diseases. Neurol Res 2009; 31: 1023-1030.
10. Dohrmann K, Elbert T, Schlee W, Weisz N. Tuning the tinnitus percept by modification of synchronous brain activity. Restor Neurol Neurosci 2007; 25: 371-378.
11. Rauschecker JP, Leaver AM, Mühlau M. Tuning out the noise: limbic-auditory interactions in tinnitus. Neuron 2010; 66: 819-826.
12. Singer W, Panford-Walsh R, Watermann D, Hendrich O, Zimmermann U, Köpschall I, Rohbock K, Knipper M. Salicylate alters the expression of calcium response transcription factor 1 in the cochlea: implications for brainderived neurotrophic factor transcriptional regulation. Mol Pharmacol 2008; 73: 1085-1091.
13. Weisz N, Wienbruch C, Dohrmann K, Elbert T. Neuromagnetic indicators of auditory cortical reorganization of tinnitus. Brain 2005; 128: 2722-2731.
14. Eggermont JJ. Role of auditory cortex in noiseand drug-induced tinnitus. Am J Audiol 2008; 17: S162-169.
15. Tan J, Rüttiger L, Panford-Walsh R, Singer W, Schulze H, Kilian SB, Hadjab S, Zimmermann U, Köpschall I, Rohbock K, Knipper M. Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma. Neuroscience 2007; 145: 715-726.
16. Martin DM, Raphael Y. Gene-based diagnostic and treatment methods for tinnitus. Int Tinnitus J 2003; 9: 3-10.
17. Feng J, Bendiske J, Morest DK. Degeneration in the ventral cochlear nucleus after severe noise damage in mice. J Neurosci Res 2012; 90: 831-841.
18. Gabaizadeh R, Staecker H, Liu W, Van De Water TR. BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione. Brain Res Mol Brain Res 1997; 50: 71-78.
19. Shoji F, Miller AL, Mitchell A, Yamasoba T, Altschuler RA, Miller JM. Differential protective effects of neurotrophins in the attenuation of noise-induced hair cell loss. Hear Res 2000; 146: 134-142.
20. Yu H, Wang DD, Wang Y, Liu T, Lee FS, Chen ZY. Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. J Neurosci 2012; 32: 4092-4101.
21. Uchida S, Hara K, Kobayashi A, Otsuki K, Yamagata H, Hobara T, Suzuki T, Miyata N, Watanabe Y. Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events. Neuron 2011; 69: 359-372.
22. Nam YJ, Stöver T, Hartman SS, Altschuler RA. Upregulation of glial cell line-derived neurotrophic factor (GDNF) in the rat cochlea following noise. Hear Res 2000; 146: 1-6.
23. Hajcak G, Castille C, Olvet DM, Dunning JP, Roohi J, Hatchwell E. Genetic variation in brainderived neurotrophic factor and human fear conditioning. Genes Brain Behav 2009; 8: 80-85.
24. Schofield PR, Williams LM, Paul RH, Gatt JM, Brown K, Luty A, Cooper N, Grieve S, Dobson-Stone C, Morris C, Kuan SA, Gordon E. Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: evidence from cognition, the P300 and fronto-hippocampal systems. Biol Psychol 2009; 80: 176-188.
25. Juckel G, Schumacher C, Giegling I, Assion HJ, Mavrogiorgou P, Pogarell O, Mulert C, Hegerl U, Norra C, Rujescu D. Serotonergic functioning as measured by the loudness dependence of auditory evoked potentials is related to a haplotype in the brain-derived neurotrophic factor (BDNF) gene. J Psychiatr Res 2010; 44: 541-546.
26. Zdanys KF, Kleiman TG, Zhang H, Ozbay F, MacAvoy MG, Gelernter J, van Dyck CH. BDNF variants, premorbid educational attainment, and disease characteristics in Alzheimer's disease: an exploratory study. J Alzheimers Dis 2009; 17: 887-898.
27. Goebel G, Hiller W. The tinnitus questionnaire. A standard instrument for grading the degree of tinnitus. Results of a multicenter study with the tinnitus questionnaire. HNO 1994; 42: 166-172.
28. Tsai SJ, Cheng CY, Yu YW, Chen TJ, Hong CJ. Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. Am J Med Genet B Neuropsychiatr Genet 2003; 123B: 19-22.
29. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
30. Dupont WD, Plummer WD Jr. Power and sample size calculations. A review and computer program. Control Clin Trials 1990; 11: 116-128.
31. Goodyer IM, Croudace T, Dudbridge F, Ban M, Herbert J. Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. Br J Psychiatry 2010; 197: 365-371.
32. Pilgramm M, Rychlick R, Lebisch H, Siedentop H, Goebel G, Kirchhoff D. (1999). Tinnitus in the Federal Republic of Germany: A representative epidemiological study. In: J. W. P. Hazell (Ed.), Proceedings of the Sixth Internantional Tinnitus Seminar (pp: 64-67). London: The Tinnitus and Hyperacusis Centre.
33. Scott B, Lindberg P. Psychological profile and somatic complaints between help-seeking and non-help-seeking tinnitus subjects. Psychosomatics 2000; 41: 347-352.
34. Hébert S, Canlon B, Hasson D, Magnusson Hanson LL, Westerlund H, Theorell T. Tinnitus severity is reduced with reduction of depressive mood--a prospective population study in Sweden. PLoS One 2012; 7: e37733.
35. Goto F, Saruta J, Kanzaki S, To M, Tsutsumi T, Tsukinoki K, Ogawa K. Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus. Neurosci Lett 2012; 510: 73-77.
36. Stöver T, Nam Y, Gong TL, Lomax MI, Altschuler RA. Glial cell line-derived neurotrophic factor (GDNF) and its receptor complex are expressed in the auditory nerve of the mature rat cochlea. Hear Res 2001; 155: 143-151.
37. Vanneste S, Joos K, De Ridder D. Prefrontal cortex based sex differences in tinnitus perception: same tinnitus intensity, same tinnitus distress, different mood. PLoS One 2012; 7: e31182.
38. Sohrabji F, Lewis DK. Estrogen-BDNF inter actions: implications for neurodegenerative diseases. Front Neuroendocrinol 2006; 27: 404-414.
39. Pinaud R, Tremere LA. Control of central auditory processing by a brain-generated oestrogen. Nat Rev Neurosci 2012.
40. McFadden D. Sex differences in the auditory system. Dev Neuropsychol 1998; 14: 261-298.
41. Rogers DS, Harkrider AW, Burchfield SB, Nabelek AK. The influence of listener's gender on the acceptance of background noise. J Am Acad Audiol 2003; 14: 372-382.
42. Sagi E, D'Alessandro LM, Norwich KH. Identification variability as a measure of loudness: an application to gender differences. Can J Exp Psychol 2007; 61: 64-70.
43. Kocak M, Ulmer JL, Biswal BB, Aralasmak A, Daniels DL, Mark LP. The influence of gender on auditory and language cortical activation patterns: preliminary data. Am J Neuroradiol 2005; 26: 2248-2255.
44. Burman DD, Bitan T, Booth JR. Sex differences in neural processing of language among children. Neuropsychologia 2008; 46: 1349-1362.
45. Krizman J, Skoe E, Kraus N. Sex differences in auditory subcortical function. Clin Neurophysiol 2012; 123: 590-597.
46. Rademacher J, Morosan P, Schleicher A, Freund HJ, Zilles K. Human primary auditory cortex in women and men. Neuroreport 2001; 12: 1561-1565.
47. Lenarz M, Sönmez H, Joseph G, Büchner A, Lenarz T. Effect of gender on the hearing performance of adult cochlear implant patients. Laryngoscope 2012; 122: 1126-1129.
48. Dobie RA, Sakai CS, Sullivan MD, Katon WJ, Russo J. Antidepressant treatment of tinnitus patients: report of a randomized clinical trial and clinical prediction of benefit. Am J Otol 1993; 14: 18-23.
49. Castrén E, Rantamäki T. The role of BDNF and its receptors in depression and antidepressant drug action: Reactivation of developmental plasticity. Dev Neurobiol 2010; 70: 289-297.
50. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL, Lee FS. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 2004; 24: 4401-4411.
51. Huang R, Huang J, Cathcart H, Smith S, Poduslo SE. Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. J Med Genet 2007; 44: e66.
52. Lemos C, Mendonça D, Pereira-Monteiro J, Barros J, Sequeiros J, Alonso I, Sousa A. BDNF and CGRP interaction: implications in migraine susceptibility. Cephalalgia 2010; 30: 1375-1382.
53. Green EK, Raybould R, Macgregor S, Hyde S, Young AH, O'Donovan MC, Owen MJ, Kirov G, Jones L, Jones I, Craddock N. Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK. Br J Psychiatry 2006; 188: 21-25.
54. Terracciano A, Tanaka T, Sutin AR, Deiana B, Balaci L, Sanna S, Olla N, Maschio A, Uda M, Ferrucci L, Schlessinger D, Costa PT Jr. BDNF Val66Met is associated with Introversion and interacts with 5-HTTLPR to influence Neuroticism. Neuropsychopharmacology 2010; 35: 1083-1089.
55. Walter NT, Montag C, Markett SA, Reuter M. Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. Psychosom Med 2011; 73: 23-28.
56. Cathomas F, Vogler C, Euler-Sigmund JC, de Quervain DJ, Papassotiropoulos A. Finemapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory. Int J Neuropsychopharmacol 2010; 13: 975-980.
57. Lavebratt C, Aberg E, Sjöholm LK, Forsell Y. Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. J Affect Disord 2010; 125: 249-255.