Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents

British Journal of Psychiatry

Volumn 197, Issue 5, 2010, Pages 365-371

  Goodyer, Ian M ^a   Croudace, Tim ^a   Dudbridge, Frank ^b   Ban, Maria ^c   Herbert, Joe ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; HYDROCORTISONE; METHIONINE; SEROTONIN TRANSPORTER; VALINE;

5 HTTLPR GENE; ADOLESCENT; ALLELE; ARTICLE; BDNF GENE; FEMALE; FOLLOW UP; GENE; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PROMOTER REGION; SALIVA LEVEL;

ADOLESCENT; ADOLESCENT PSYCHOLOGY; ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CIRCADIAN RHYTHM; DEPRESSIVE DISORDER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYDROCORTISONE; LIFE CHANGE EVENTS; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SALIVA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 78249232054     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.110.077750     Document Type: Article

References (35)

1. Dunn V, Goodyer IM. Longitudinal investigation into childhood- and adolescence-onset depression: psychiatric outcome in early adulthood. Br J Psychiatry 2006; 188: 216-22.
2. Fombonne E, Wostear G, Cooper V, Harrington R, Rutter M. The Maudsley long-term follow-up of child and adolescent depression. 1. Psychiatric outcomes in adulthood. Br J Psychiatry 2001; 179: 210-7.
3. Donnelly P. Progress and challenges in genome-wide association studies in humans. Nature 2008; 456: 728-31.
4. Hasler G, Drevets WC, Manji HK, Charney DS. Discovering endophenotypes for major depression. Neuropsychopharmacology 2004; 29: 1765-81.
5. Goodyer IM. Emanuel Miller Lecture: early onset depressions - meanings, mechanisms and processes. J Child Psychol Psychiatry 2008; 49: 1239-56.
6. Mannie ZN, Harmer CJ, Cowen PJ. Increased waking salivary cortisol levels in young people at familial risk of depression. Am J Psychiatry 2007; 164: 617-21.
7. Goodyer IM, Herbert J, Tamplin A, Altham PME. Recent life events, cortisol, dehydroepiandrosterone and the onset of major depression in high-risk adolescents. Br J Psychiatry 2000; 177: 499-504.
8. Kumamaru E, Numakawa T, Adachi N, Yagasaki Y, Izumi A, Niyaz M, et al. Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase. Mol Endocrinol 2008; 22: 546-58.
9. Huang GJ, Herbert J. Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone. Biol Psychiatry 2006; 59: 619-24.
10. Pinnock SB, Herbert J. Brain-derived neurotropic factor and neurogenesis in the adult rat dentate gyrus: interactions with corticosterone. Eur J Neurosci 2008; 27: 2493-500.
11. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003; 112: 257-69.
12. Verhagen M, van der Meij A, van Deurzen PA, Janzing JG, Arias-Vasquez A, Buitelaar JK, et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 2010; 15: 260-71.
13. Strauss J, Barr CL, George CJ, King N, Shaikh S, Devlin B, et al. Association study of brain-derived neurotrophic factor in adults with a history of childhood onset mood disorder. Am J Med Genet B Neuropsychiatr Genet 2004; 131B: 16-9.
14. Pezawas L, Meyer-Lindenberg A, Goldman AL, Verchinski BA, Chen G, Kolachana BS, et al. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Mol Psychiatry 2008; 13: 654, 709-16.
15. Forbes EE. Where's the fun in that? Broadening the focus on reward function in depression. Biol Psychiatry 2009; 66: 199-200.
16. Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nat Neurosci 2007; 10: 1089-93.
17. Risch N, Herrell R, Lehner T, Liang KY, Eaves L, Hoh J, et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 2009; 301: 2462-71.
18. Monroe SM, Reid MW. Gene-environment interactions in depression research: genetic polymorphisms and life-stress polyprocedures. Psychol Sci 2008; 19: 947-56.
19. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry 2010; 15: 18-22.
20. Goodyer IM, Bacon A, Ban M, Croudace T, Herbert J. Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents. Br J Psychiatry 2009; 195: 39-45.
21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorder (4th edn) (DSM-IV). APA, 1994.
22. Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moreci P, et al. Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997; 36: 980-8.
23. Shaffer D, Gould MS, Brasio J, Ambrosini P, Fisher P, Bird H, et al. A Children's Global Assessment Scale (CGAS). Arch Gen Psychiatry 1983; 40: 1228-31.
24. Kent L, Vostanis P, Feehan C. Detection of major and minor depression in children and adolescents: evaluation of the Mood and Feelings Questionnaire. J Child Psychol Psychiatry 1997; 38: 565-73.
25. Daviss WB, Birmaher B, Melhem NA, Axelson DA, Michaels SM, Brent DA. Criterion validity of the Mood and Feelings Questionnaire for depressive episodes in clinic and non-clinic subjects. J Child Psychol Psychiatry 2006; 47: 927-34.
26. Harrell JEF. Regression Modelling Strategies: With Applications to Linear Models, Logistic Regression and Survival Analysis. Springer, 2005.
27. Adachi M, Barrot M, Autry AE, Theobald D, Monteggia LM. Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 2008; 63: 642-9.
28. Jaffee SR, Moffitt TE, Caspi A, Fombonne E, Poulton R, Martin J. Differences in early childhood risk factors for juvenile-onset and adult-onset depression. Arch Gen Psychiatry 2002; 59: 215-22.
29. Brown GW, Harris TO. Depression and the serotonin transporter 5-HTTLPR polymorphism: a review and a hypothesis concerning gene-environment interaction. J Affect Disord 2008; 111: 1-12.
30. Jacobs N, Kenis G, Peeters F, Derom C, Vlietinck R, Van Os J. Stress-related negative affectivity and genetically altered serotonin transporter function: evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 2006; 63 989-96.
31. Canli T, Ferri J, Duman EA. Genetics of emotion regulation. Neuroscience 2009; 164: 43-54.
32. Munafo MR, Durrant C, Lewis G, Flint J. Gene X environment interactions at the serotonin transporter locus. Biol Psychiatry 2009; 65: 211-9.
33. Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF, et al. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol Psychiatry 2009; March 3 (Epub ahead of print).
34. Ouellet-Morin I, Boivin M, Dionne G, Lupien SJ, Arseneault L, Barr RG, et al. Variations in heritability of cortisol reactivity to stress as a function of early familial adversity among 19-month-old twins. Arch Gen Psychiatry 2008; 65: 211-8.
35. Cools R, Roberts AC, Robbins TW. Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn Sci 2008; 12: 31-40.