BDNF variants, premorbid educational attainment, and disease characteristics in alzheimer's disease: An exploratory study

Journal of Alzheimer's Disease

Volumn 17, Issue 4, 2009, Pages 887-898

  Zdanys, Kristina F ^a   Kleiman, Timothy G ^a   Zhang, Huiping ^b   Ozbay, Fatih ^b   MacAvoy, Martha G ^a   Gelernter, Joel ^a,b   Van Dyck, Christopher H ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Alzheimer's Disease Research Unit   (United States)

^c Division of Human Genetics   (United States)

Author keywords

Activities of daily living; Alzheimer's disease; Brain derived neurotrophic factor; Cognition; Education; Single nucleotide polymorphism

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; COGNITIVE DEFECT; DISEASE COURSE; DISEASE SEVERITY; EDUCATIONAL STATUS; FEMALE; GENETIC VARIABILITY; GENOTYPE; HALLUCINATION; HOMOZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; MENTAL DISEASE; ONSET AGE; PRIORITY JOURNAL; PROTEIN SECRETION; SINGLE NUCLEOTIDE POLYMORPHISM; COGNITION; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; HALLUCINATIONS; PATHOPHYSIOLOGY; POLYMERASE CHAIN REACTION; PREVALENCE; PSYCHOLOGY; RETROSPECTIVE STUDY; SEVERITY OF ILLNESS INDEX; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION; DISEASE PROGRESSION; EDUCATIONAL STATUS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HALLUCINATIONS; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; RETROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 68949163661     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2009-1106     Document Type: Article

References (70)

1. Huang ZJ, Kirkwood A, Pizzorusso T, Porciatti V, Morales B, Bear MF, Maffei L, Tonegawa S (1999) BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. Cell 98, 739-755.
2. Gorski JA, Zeiler SR, Tamowski S, Jones KR (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23, 6856-6865.
3. Kalb R (2005) The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci 28, 5-11.
4. Lee JL, Everitt BJ, Thomas KL (2004) Independent cellular processes for hippocampal memory consolidation and recon-solidation. Science 304, 839-843.
5. Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T, Meuth S, Nagy A, Greene RW, Nestler EJ (2004) Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA 101, 10827-10832.
6. Fumagalli F, Racagni G, Riva MA (2006) The expanding role of BDNF: a therapeutic target for Alzheimer's disease? Pharmacogenomics J 6, 8-15.
7. Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW (1991) BDNF messenger RNA is decreased in the hippocampus of individuals with Alzheimer's disease. Neuron 7, 695-702.
8. Holsinger RM, Schnarr J, Henry P, Castelo VT, Fahnestock M (2000) Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Brain Res Mol Brain Res 76, 347-354.
9. Hock C, Heese K, Hulette C, Rosenberg C, Otten U (2000) Region-specific neurotrophin imbalances in Alzheimer disease: decreased levels of brain-derived neurotrophic factor and increased levels of nerve growth factor in hippocampus and cortical areas. Arch Neurol 57, 846-851.
10. Peng S, Wuu J, Mufson EJ, Fahnestock M (2005) Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem 93, 1412-1421.
11. Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M (2005) Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Exp Neurol 194, 91-96.
12. Laske C, Stransky E, Leyhe T, Eschweiler GW, Wittorf A, Richartz E, Bartels M, Buchkremer G, Schott K (2006) Stage-dependent BDNF serum concentrations in Alzheimer's disease. J Neural Transm 113, 1217-1224.
13. MatsushitaS,Arai H, Matsui T,Yuzuriha T,Urakami K, Masa-ki T, Higuchi S (2005) Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease. J Neural Transm 112, 703-711.
14. Nishimura M, Kuno S, Kaji R, Kawakami H (2005) Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy. Mov Disord 20, 1031-1059.
15. Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S (2001) A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 6, 83-86.
16. Olin D, MacMurray J, Comings DE (2005) Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neurosci Lett 381, 275-278.
17. Riemenschneider M, Schwarz S, Wagenpfeil S, Diehl J, Muller U, Forstl H, Kurz A (2002) A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the Apolipoprotein E epsilon 4 allele. Mol Psychiatry 7, 782-785.
18. Bagnoli S, Nacimas B, Tedde A, Guarnieri BM, Cellini E, Petruzzi C, Bartoli A, Ortenzi L, Sorbi S (2004) Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy. Ann Neurol 55, 447-448.
19. Desai P, Nebes R, DeKosky ST, Kamboh MI (2005) Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression. Neurosci Lett 379, 229-234.
20. Bodner SM, Berrettini W, van Deerlin V, Bennett DA, Wilson RS, Trojanowski JQ, ArnoldSE(2005) Geneticvariationin the brain derived neurotrophic factor gene in Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 134, 1-5.
21. Saarela MS, Lehtimaki T, Rinne JO, Huhtala H, Rontu R (2006) No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease. Folia Neuropathol 44, 12-16.
22. Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I, Shimohama S, Kosaka K (2006) Variations in the BDNF gene with Lewy Bodies in Japan. Dement Geriatr Cogn Disord 22, 216-222.
23. Tsai SJ, Hong CJ, Liu HC, Liu TY, Liou YJ (2006) The brain-derived neurotrophic factor gene as a possible susceptibility candidate for Alzheimer's disease in a Chinese population. Dement Geriatr Cogn Disord 21, 139-143.
24. Zhang H, Ozbay F, Lappalainen J, Kranzler HR, van Dyck CH, Charney DS, Rosenheck R, Price LH, Southwick S, Yang B-Z, Gelernter J (2006) Brain Derived Neurotrophic Factor (BD-NF) genetic variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia and substance dependence. Am J Med Genet B Neuropsychiatr Genet 141, 387-393.
25. Huang R, Huang J, Cathcart H, Smith S, Poduslo SE (2007) Genetic variants in brain-derived neurotrophic factor associated with Alzheimer's disease. J Med Genet 44, e66.
26. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269.
27. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Cal-licott JH, Egan MF, Weinberger DR (2003) Brain-derived neurotrophic factor val(66)met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23, 6690-6694.
28. Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hemp-stead BL, Lee FS (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurose-cretory cells and cortical neurons. J Neurosci 24, 4401-4411.
29. Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Ko-lachana BS, Straub RE, Egan MF, Meyer-Lindenberg A, Weinberger DR (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24, 10099-10102.
30. Dempster E, Toulopoulou T, McDonald C, Bramon E, Walshe M, Filbey F, Wickham H, Sham PC, Murray RM, Collier DA (2005) Association between BDNF val66met genotype and episodic memory. Am J Med Genet B Neuropsychiatr Genet 134, 73-75.
31. Tsai SJ, Hong CJ, Liu HC, Liu TY, Hsu LE, Lin CH (2004) Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset. Neuropsychobiology 49, 10-12.
32. Combarros O, Infante J, Llorca J, Berciano J (2004) Polymorphism at codon 66 of the brain-derived neurotrophic fac- tor gene is not associated with sporadic Alzheimer's disease. Dement Geriatr Cogn Disord 18, 55-58.
33. Nacmias B, Piccini C, Bagnoli S, Tedde A, Cellini E, Brac-co L, Sorbi S (2004) Brain-derived neurotrophic factor, apolipoprotein E genetic variants and cognitive performance in Alzheimer's disease. Neurosci Lett 367, 379-383.
34. Bagnoli S, Nacmias B, Tedde A, Guarnieri BM, Cellini E, Petruzzi C, Bartoli A, Ortenzi L, Sorbi S (2004) Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy. Ann Neurol 55, 447-448.
35. Li Y, Rowland C, Tacey K, Catanese J, Sninsky J, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Goate A, Owen M, Williams JG, A. (2005) The BDNF val66met polymorphism is not associated with late-onset Alzheimer's disease in three case-control samples. Mol Psychiatry 10, 809-810.
36. Bian J-T, Zhang J-W, Zhang Z-X, Zhao H-L (2005) Association analysis of brain-derived neurotrophic factor (BDNF) gene 196 A/G polymorphism with Alzheimer's disease (AD) in mainland Chinese. Neurosci Lett 387, 11-16.
37. He XM, Zhang ZX, Zhang JW, Zhou YT, Tang MN, Wu CB, Hong Z (2007) Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population. Neuropsychobiology 55, 151-155.
38. Ventriglia M, Chiavetto LB, Benussi L, Binetti G, Zanetti O, Riva MA, Gennarelli M (2002) Association between the BD-NF 196 A/G polymorphism and sporadic Alzheimer's disease. Mol Psychiatry 7, 136-137.
39. Chuu JY-J, Taylor JL, Tinklenberg J, Noda A, Yesavage J (2006) The brain-derived neurotrophic factor val66met polymorphism and rate of decline in Alzheimer's disease. J Alzheimers Dis 9, 43-49.
40. Borroni B, Archetti S, Costanzi C, Grassi M, Ferrari M, Radeghieri A, Caimi L, Caltagirone C, Di Luca M, Padovani A (2008) Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression. Neurobiol Aging, in press.
41. Snowdon DA, Kemper SJ, Mortimer JA, Greiner LH, Wekstein DR, Markesbery WR (1996) Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. JAMA 275, 528-532.
42. Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J (2004) Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia. Proc Natl Acad Sci USA 101, 284-289.
43. Zhang MY, Katzman R, Salmon D, Jin H, Cai GJ, Wang ZY, QuGY,GrantI,YuE,LevyP,KlauberMR,LiuWT(1990)The prevalence of dementia and Alzheimer's disease in Shanghai, China: impact of age, gender, and education. Ann Neurol 27, 428-437.
44. Stern Y, Gurland B, Tatemichi TK, Tang MX, Wilder D, Mayeux R (1994) Influence of education and occupation on the incidence of Alzheimer's disease. JAMA 271, 1004-1010.
45. Letenneur L, Commenges D, Dartigues JF, Barberger-Gateau P (1994) Incidence of dementia and Alzheimer's disease in elderly community residents of south-western France. Int J Epidemiol 23, 1256-1261.
46. Ott A, Breteler MM, van Harskamp F, Claus JJ, van der Cammen TJ, Grobbee DE, Hofman A (1995) Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study. BMJ 310, 970-973.
47. Evans DA, Hebert LE, Beckett LA, Scherr PA, Albert MS, Chown MJ, Pilgrim DM, Taylor JO (1997) Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons. Arch Neurol 54, 1399-1405.
48. Launer LJ, Andersen K, Dewey ME, Letenneur L, Ott A, Amaducci LA, Brayne C, Copeland JR, Dartigues JF, Kragh-Sorensen P, Lobo A, Martinez-Lage JM, Stijnen T, Hofman A (1999) Rates and risk factors for dementia and Alzheimer's disease: results from EURODEM pooled analyses. EURO-DEM Incidence Research Group and Work Groups. European Studies of Dementia. Neurology 52, 78-84.
49. Qiu C, Bäckman L, Winblad B, Agüero-Torres H, Fratiglioni L (2001) The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen Project. Arch Neurol 58, 2034-2039.
50. Lindsay J, Laurin D, Verrault R, Hebert R, Helliwell B, McDowell I (2002) Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging. Am J Epidemiol 156, 445-453.
51. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: reportofthe NINCDS-ADRDA work group underthe auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology 34, 939-944.
52. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brown-lee LM, Vogel FS, Hughes JP, van Belle G, Berg L (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479-486.
53. Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
54. Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer's disease. Am J Psychiatry 141, 1356-1364.
55. Lawton MP, Brody EM (1969) Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9, 179-186.
56. Galasko D, Bennett D, Sano M, Ernesto C, Thomas R, Grund-man M, Ferris S (1997) An inventory to assess activities of daily living for clinical trials in Alzheimer's disease. The Alzheimer's Disease Cooperative Study. Alzheimer Dis Assoc Disord 11, 33-39.
57. Kleiman TG, Zdanys KF, MacAvoy MG, Rightmer TE, Black BT, Grey M, Morgan K, Gelernter J, van Dyck CH (2006) Apolipoprotein E e4 allele does not affect cognitive or functional decline in Alzheimer's Disease. Dement Geriatr Cogn Disord 22, 73-82.
58. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia. Neurology 44, 2308-2314.
59. Zdanys K, Kleiman T, MacAvoy M, Black B, Rightmer T, Grey M, Garman K, Tampi R, Gelernter J, van Dyck C (2007) Apolipoprotein E epsilon4 allele increases risk for psychotic symptoms inAlzheimer's disease. Neuropsychopharmacology 32, 172-179.
60. Nanko S, Kunugi H, Hirasawa H, Kato N, Nabika T, Kobayashi S (2003) Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr Res 62, 281-283.
61. Stern Y (2006) Cognitive reserve and Alzheimer disease. Alzheimer Dis Assoc Disord 20, 112-117.
62. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261, 921-923.
63. Farrer LA, Cupples LA, Haines JL, Hyman BT, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch NJ, van Duijn CM (1997) Effects of age, sex and ethnicity on the association between apolipoprotein Egenotype and Alzheimer disease - A meta-analysis. JAMA 278, 1349-1356.
64. Szekeres G, Juhasz A, Rimanoczy A, Keri S, Janka Z (2003) The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia. Schizophr Res 65, 15-18.
65. Durany N, Thome J(2004) Neurotrophic factors and the patho-physiology of schizophrenic psychoses. Eur Psychiatry 19, 326-337.
66. Jonsson EG, Edman-Ahlbom B, Sillen A, Gunnar A, Kulle B, Frigessi A, Vares M, Ekholm B, Wode-Helgodt B, Schumacher J, Cichon S, Agartz I, Sedvall GC, Hall H, Terenius L (2006) Brain-derived neurotrophic factor gene variants and schizophrenia: an association study. Prog Neuropsychophar-macol Biol Psychiatry 30, 924-933.
67. Szczepankiewicz A, Skibinska M, Czerski PM, Kapelski P, Leszczynska-Rodziewicz A,Slopien A, Dmitrzak-Weglarz M, Rybakowski JK, Hauser J (2005) No association of the brain-derived neurotrophic factor (BDNF) gene C-270T polymorphism with schizophrenia. Schizophr Res 76, 187-193.
68. Watanabe Y, Muratake T, Kaneko N, Nunokawa A, Someya T (2006) No association between the brain-derived neurotroph-ic factor gene and schizophrenia in a Japanese population. Schizophr Res 84, 29-35.
69. Kokmen E, Ozsarfati Y, Beard CM, O'Brien PC, Rocca WA (1996) Impact of referral bias on clinical and epidemiological studies of Alzheimer's disease. J Clin Epidemiol 49, 79-83.
70. Watson JS, Matsuyama SS, Dirham PM, Liston EH, La Rue A, Jarvik LF (1987) Relatives' descriptions of changes in symptoms of dementia of the Alzheimer type: a comparison of retrospective and concurrent ratings. Alzheimer Dis Assoc Disord 1, 98-102.