A tri-copper(II) complex displaying DNA-cleaving properties and antiproliferative activity against cancer cells

Chemistry - A European Journal

Volumn 18, Issue 47, 2012, Pages 15133-15141

  Suntharalingam, Kogularamanan ^a   Hunt, Douglas J ^a   Duarte, Alexandra A ^a   White, Andrew J P ^a   Mann, David J ^a   Vilar, Ramon ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

cancer; copper; DNA; DNA cleavage; oxidative cleavage

Indexed keywords

ANTIPROLIFERATIVE ACTIVITIES; BINDING AFFINITIES; BINDING MODES; CANCER; CANCER CELL LINES; CANCER CELLS; CELL-BASED; CELLULAR DNA DAMAGE; CELLULAR TOXICITIES; CELLULAR UPTAKE; DIRECT LINKS; DNA CLEAVAGE; DNA DAMAGE RESPONSE; DUPLEX DNA; GROOVE BINDING; IMMUNOBLOTTING ANALYSIS; LEUKAEMIA CELLS; OXIDATIVE CLEAVAGES; PLASMID DNA; PROTEIN LEVEL; TERPYRIDINES;

BINDING ENERGY; CELL CULTURE; CELLS; COPPER; CYTOTOXICITY; DNA; ELECTROPHORESIS; PLATINUM COMPOUNDS;

COPPER COMPOUNDS;

ANTINEOPLASTIC AGENT; CALF THYMUS DNA; COPPER; DNA; ORGANOMETALLIC COMPOUND;

ARTICLE; CELL PROLIFERATION; CELL STRAIN HEK293; CHEMICAL STRUCTURE; CHEMISTRY; DNA CLEAVAGE; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; COPPER; CRYSTALLOGRAPHY, X-RAY; DNA; DNA CLEAVAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869118390     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201202482     Document Type: Article

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