Anomalous behavior of pentacoordinate copper complexes of dimethylphenanthroline and derivatives of terpyridine ligands: Studies on DNA binding, cleavage and apoptotic activity

European Journal of Medicinal Chemistry

Volumn 46, Issue 2, 2011, Pages 608-617

  Rajalakshmi, Subramaniyam ^a   Weyhermüller, Thomas ^b   Freddy, Allen J ^c   Vasanthi, Hannah R ^c   Nair, Balachandran Unni ^a  

^a CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^b MAX PLANCK INSTITUTE FOR CHEMICAL ENERGY CONVERSION   (Germany)

^c SRI RAMACHANDRA UNIVERSITY   (India)

Author keywords

Apoptosis; Copper complexes; Cytotoxicity; DNA binding; DNA cleavage; Groove binder

Indexed keywords

ANTINEOPLASTIC AGENT; COPPER DERIVATIVE; DIMETHYLPHENANTHROLINE; DNA; PHENANTHROLINE DERIVATIVE; PYRIDINE DERIVATIVE; TERPYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CHEMICAL REACTION; CONTROLLED STUDY; DNA BINDING; DNA CLEAVAGE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG CANCER; SPECTROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CATTLE; CELL LINE, TUMOR; COPPER; CRYSTALLOGRAPHY, X-RAY; DNA; DNA CLEAVAGE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; PHENANTHROLINES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79151475439     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.041     Document Type: Article

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