Hypovitaminosis D and peripheral arterial disease: Emerging link beyond cardiovascular risk factors

European Journal of Internal Medicine

Volumn 23, Issue 8, 2012, Pages 674-681

  Gouveri, E ^a   Papanas, N ^a   Hatzitolios, A I ^b   Maltezos, E ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Atherosclerosis; Cardiovascular disease; Peripheral arterial disease; Vitamin D

Indexed keywords

ANKLE BRACHIAL INDEX; CARDIOVASCULAR RISK; DISEASE ASSOCIATION; DISEASE COURSE; GROUPS BY AGE; HUMAN; MORBIDITY; MORTALITY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSICAL ACTIVITY; PREDICTOR VARIABLE; PREVALENCE; REVIEW; SUN EXPOSURE; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION;

EID: 84869096143     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2012.07.001     Document Type: Short Survey

References (104)

1. M.F. Holick Vitamin D deficiency N Engl J Med 357 2007 266 281
2. M.F. Holick The vitamin D epidemic and its health consequences J Nutr 135 2005 2739S 2748S (Pubitemid 43156624)
3. H.T. May, T.L. Bair, D.L. Lappé, J.L. Anderson, B.D. Horne, and J.F. Carlquist Association of vitamin D levels with incident depression among a general cardiovascular population Am Heart J 159 2010 1037 1043
4. K. Barnard, and C. Colón-Emeric Extraskeletal effects of vitamin D in older adults: cardiovascular disease, mortality, mood, and cognition Am J Geriatr Pharmacother 8 2010 4 33
5. S. Makariou, E.N. Liberopoulos, M. Elisaf, and A. Challa Novel roles of vitamin D in disease: what is new in 2011? Eur J Intern Med 22 2011 355 362
6. C.J. Rosen Clinical practice. Vitamin D insufficiency N Engl J Med 364 2011 248 254
7. J.P. Reis, D. von Mühlen, E.D. Michos, E.R. Miller III, L.J. Appel, and M.R. Araneta Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis Atherosclerosis 207 2009 585 590
8. A.G. Pittas, M. Chung, T. Trikalinos, J. Mitri, M. Brendel, and K. Patel Systematic review: vitamin D and cardiometabolic outcomes Ann Intern Med 152 2010 307 314
9. B.A. Golomb, T.T. Dang, and M.H. Criqui Peripheral arterial disease: morbidity and mortality implications Circulation 114 2006 688 699 (Pubitemid 44252311)
10. J.W. Olin, and B.A. Sealove Peripheral artery disease: current insight into the disease and its diagnosis and management Mayo Clin Proc 85 2010 678 692
11. E. Selvin, and T.P. Erlinger Prevalence of and risk factors for peripheral arterial disease in the United States: results from the National Health and Nutrition Examination Survey, 1999-2000 Circulation 110 2004 738 743 (Pubitemid 39056275)
12. J.J. Belch, E.J. Topol, G. Angelli, M. Bertrand, R.M. Califf, and D.L. Clement Critical issues in peripheral arterial disease detection and management: a call to action Arch Intern Med 163 2003 884 892 (Pubitemid 36519734)
13. P.M. Ridker, M.J. Stampfer, and N. Rifai Novel risk factors for systemic atherosclerosis: a comparison of C-reactive protein, fibrinogen, homocysteine, lipoprotein(a), and standard cholesterol screening as predictors of peripheral arterial disease JAMA 285 2001 2481 2485 (Pubitemid 32433842)
14. A.M. Wilson, E. Kimura, R.K. Harada, N. Nair, B. Narasimhan, and X.Y. Meng Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies Circulation 116 2007 1396 1403 (Pubitemid 47417566)
15. V.C. Gaddipati, R. Kuriacose, R. Copeland, B.A. Bailey, and A.N. Peiris Vitamin D deficiency: an increasing concern in peripheral arterial disease J Am Med Dir Assoc 11 2010 308 311
16. W. Rooke, A.T. Hirsch, S. Misra, A.N. Sidawy, J.A. Beckman, and L.K. Findeiss 2011 ACCF/AHA Focused Update of the Guideline for the Management of Patients with Peripheral Artery Disease (updating the 2005 guideline): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 58 2011 2020 2045
17. Ankle Brachial Index Collaboration F.G. Fowkes, G.D. Murray, I. Butcher, C.L. Heald, and R.J. Lee Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis JAMA 300 2008 197 208 (Pubitemid 351969304)
18. N. Papanas, D. Kakagia, K. Papatheodorou, D. Papazoglou, M. Alexandridou, and A. Pagkalos Lanarkshire Oximetry Index as a diagnostic tool for peripheral arterial disease in type 2 diabetes: a pilot study Angiology 61 2010 388 391
19. W.R. Hiatt Medical treatment of peripheral arterial disease and claudication N Engl J Med 344 2001 1608 1621 (Pubitemid 32479915)
20. C.L. Heald, F.G. Fowkes, G.D. Murray, J.F. Price Ankle Brachial Index Collaboration Risk of mortality and cardiovascular disease associated with the ankle-brachial index: systematic review Atherosclerosis 189 2006 61 69 (Pubitemid 44441297)
21. M.H. Criqui, R.D. Langer, A. Fronek, H.S. Feigelson, M.R. Klauber, and T.J. McCann Mortality over a period of 10 years in patients with peripheral arterial disease N Engl J Med 326 1992 381 386
22. Institute of Medicine, of the National Academies Dietary reference intakes for calcium and vitamin D Released November 30, 2010. Available at: www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D. aspx [accessed 3.2.12]
23. M.F. Holick, N.C. Binkley, H.A. Bischoff-Ferrari, C.M. Gordon, D.A. Hanley, and R.P. Heaney Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline J Clin Endocrinol Metab 96 2011 1911 1930
24. G. Jones Pharmacokinetics of vitamin D toxicity Am J Clin Nutr 88 2008 582S 586S [Suppl.]
25. A. Zadshir, N. Tareen, D. Pan, K. Norris, and D. Martins The prevalence of hypovitaminosis D among US adults: data from the NHANES III Ethn Dis 15 2005 S5 S101
26. J.L. Anderson, H.T. May, B.D. Horne, T.L. Bair, N.L. Hall, and J.F. Carlquist Relation of vitamin D deficiency to cardiovascular risk factors, disease status, and incident events in a general healthcare population Am J Cardiol 106 2010 963 968
27. A. Steinvil, E. Leshem-Rubinow, S. Berliner, D. Justo, T. Finn, and M. Ish-shalom Vitamin D deficiency prevalence and cardiovascular risk in Israel Eur J Clin Invest 41 2011 263 268
28. M.F. Holick, E.S. Siris, N. Binkley, M.K. Beard, A. Khan, and J.T. Katzer Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy J Clin Endocrinol Metab 90 2005 3215 3224 (Pubitemid 41014278)
29. D.R. Fraser Vitamin D Lancet 345 1995 104 107
30. D.E. Lawson, A.A. Paul, A.E. Black, T.J. Cole, A.R. Mandal, and M. Davie Relative contributions of diet and sunlight to vitamin D state in the elderly Br Med J 2 1979 303 305 (Pubitemid 9234298)
31. M.F. Holick Environmental factors that influence the cutaneous production of vitamin D Am J Clin Nutr 61 1995 638S 645S
32. C. Mathieu Vitamin D and diabetes: the devil is in the D-tails Diabetologia 53 2010 1545 1548
33. P. Lips, D. Hosking, K. Lippuner, J.M. Norquist, L. Wehren, and G. Maalouf The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation J Intern Med 260 2006 245 254 (Pubitemid 44253638)
34. A.S. Dusso, A.J. Brown, and E. Slatopolsky Vitamin D Am J Physiol Renal Physiol 289 2005 F8 F28
35. R.M. Lucas, M.H. Repacholi, and A.J. McMichael Is the current public health message on UV exposure correct? Bull World Health Organ 84 2006 485 491 (Pubitemid 43845449)
36. W.B. Grant In defense of the sun: an estimate of changes in mortality rates in the United States if mean serum 25-hydroxyvitamin D levels were raised to 45ng/mL by solar ultraviolet-B irradiance Dermato-Endocrinol 1 2009 207 214
37. M.F. Holick, and T.C. Chen Vitamin D deficiency: a worldwide problem with health consequences Am J Clin Nutr 87 2008 1080S 1086S (Pubitemid 351549267)
38. P.E. Norman, and J.T. Powell Vitamin D, shedding light on the development of disease in peripheral arteries Arterioscler Thromb Vasc Biol 25 2005 39 46 (Pubitemid 40054252)
39. B. Dawson-Hughes, A. Mithal, J.P. Bonjour, S. Boonen, P. Burckhardt, and G.E. Fuleihan IOF position statement: vitamin D recommendations for older adults Osteoporos Int 21 2010 1151 1154
40. L.C. Brewer, E.D. Michos, and J.P. Reis Vitamin D in atherosclerosis, vascular disease, and endothelial function Curr Drug Targets 12 2011 54 60
41. C.D. Engelman, T.E. Fingerlin, C.D. Langefeld, P.J. Hicks, S.S. Rich, and L.E. Wagenknecht Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans J Clin Endocrinol Metab 93 2008 3381 3388
42. E.M. Mallah, M.F. Hamad, M.A. Elmanaseer, N.A. Qinna, N.M. Idkaidek, and T.A. Arafat Plasma concentrations of 25-hydroxyvitamin D among Jordanians: effect of biological and habitual factors on vitamin D status BMC Clin Pathol 11 2011 8
43. M.B. Snijder, R.M. van Dam, M. Visser, D.J. Deeg, J.M. Dekker, and L.M. Bouter Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women J Clin Endocrinol Metab 90 2005 4119 4123 (Pubitemid 41058184)
44. M.K. Thomas, D.M. Lloyd-Jones, R.I. Thadhani, A.C. Shaw, D.J. Deraska, and B.T. Kitch Hypovitaminosis D in medical inpatients N Engl J Med 338 1998 777 783 (Pubitemid 28135983)
45. T.J. Wang, M.J. Pencina, S.L. Booth, P.F. Jacques, E. Ingelsson, and K. Lanier Vitamin D deficiency and risk of cardiovascular disease Circulation 117 2008 503 511
46. M.L. Melamed, E.D. Michos, W. Post, and B. Astor 25-Hydroxyvitamin D levels and the risk of mortality in the general population Arch Intern Med 168 2008 1629 1637
47. H. Dobnig, S. Pilz, H. Scharnagl, W. Renner, U. Seelhorst, and B. Wellnitz Independent association of low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels with all-cause and cardiovascular mortality Arch Intern Med 168 2008 1340 1349 (Pubitemid 351930842)
48. D.H. Kim, S. Sabour, U.N. Sagar, S. Adams, and D.J. Whellan Prevalence of hypovitaminosis D in cardiovascular diseases (from the National Health and Nutrition Examination Survey 2001 to 2004) Am J Cardiol 102 2008 1540 1544
49. D. Martins, M. Wolf, D. Pan, A. Zadshir, N. Tareen, and R. Thadhani Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey Arch Intern Med 167 2007 1159 1165 (Pubitemid 46919818)
50. N.C. Grandi, L.P. Breitling, and H. Brenner Vitamin D and cardiovascular disease: systematic review and meta-analysis of prospective studies Prev Med 51 2010 228 233
51. M.B. Elamin, N.O. Abu Elnour, K.B. Elamin, M.M. Fatourechi, A.A. Alkatib, and J.P. Almandoz Vitamin D and cardiovascular outcomes: a systematic review and meta-analysis J Clin Endocrinol Metab 96 2011 1931 1942
52. M.J. Boland, A. Grey, A. Avenell, G.D. Gamble, and I.R. Reid Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis BMJ 342 2011 d2040 10.1136/bmj.d2040
53. M.L. Melamed, P. Muntner, E.D. Michos, J. Uribarri, C. Weber, and J. Sharma Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: results from NHANES 2001 to 2004 Arterioscler Thromb Vasc Biol 28 2008 1179 1185
54. J.P. Reis, E.D. Michos, D. von Mühlen, and E.R. Miller III Differences in vitamin D status as a possible contributor to the racial disparity in peripheral arterial disease Am J Clin Nutr 88 2008 1469 1477
55. A. Fahrleitner, H. Dobnig, A. Obernosterer, E. Pilger, G. Leb, and K. Weber Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease J Gen Intern Med 17 2002 663 669 (Pubitemid 35013975)
56. A. Fahrleitner-Pammer, A. Obernosterer, E. Pilger, H. Dobnig, H.P. Dimai, and G. Leb Hypovitaminosis D, impaired bone turnover and low bone mass are common in patients with peripheral arterial disease Osteoporos Int 16 2005 319 324 (Pubitemid 40379432)
57. M. Zagura, M. Serg, P. Kampus, M. Zilmer, J. Eha, and E. Unt Aortic stiffness and vitamin D are independent markers of aortic calcification in patients with peripheral arterial disease and in healthy subjects Eur J Vasc Endovasc Surg 42 2011 689 695
58. V.C. Gaddipati, B.A. Bailey, R. Kuriacose, R.J. Copeland, T. Manning, and A.N. Peiris The relationship of vitamin D status to cardiovascular risk factors and amputation risk in veterans with peripheral arterial disease J Am Med Dir Assoc 12 2011 58 61
59. E.S. Ford, G. Zhao, C. Li, and W.S. Pearson Serum concentrations of vitamin D and parathyroid hormone and prevalent metabolic syndrome among adults in the United States J Diabetes 1 2009 296 303
60. P.M. Timms, N. Mannan, G.A. Hitman, K. Noonan, P.G. Mills, and D. Syndercombe-Court Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM 95 2002 787 796 (Pubitemid 36032948)
61. S.S. Schleithoff, A. Zittermann, G. Tenderich, H.K. Berthold, P. Stehle, and R. Koerfer Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial Am J Clin Nutr 83 2006 754 759 (Pubitemid 44713136)
62. M.M. Oosterwerff, E.M. Eekhoff, M.W. Heymans, P. Lips, and N.M. van Schoor Serum 25-hydroxyvitamin D levels and the metabolic syndrome in older persons: a population-based study Clin Endocrinol (Oxf) 75 2011 608 613
63. S.A. Chacko, Y. Song, J.E. Manson, L. Van Horn, C. Eaton, and L.W. Martin Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women Am J Clin Nutr 94 2011 209 217
64. C. Dokos, C. Savopoulos, and A. Hatzitolios Reconsider hypertension phenotypes and osteoporosis J Clin Hypertens (Greenwich) 13 2011 E1 E2 10.1111/j.1751-7176.2010.00407.x
65. S. Pilz, A. Tomaschitz, E. Ritz, and T.R. Pieber Vitamin D status and arterial hypertension: a systematic review Nat Rev Cardiol 6 2009 621 630
66. Y.C. Li, J. Kong, M. Wei, Z.F. Chen, S.Q. Liu, and L.P. Cao 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system J Clin Invest 110 2002 229 238 (Pubitemid 34787360)
67. 3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice Kidney Int 74 2008 170 179 (Pubitemid 351915078)
68. G. Rammos, P. Tseke, and S. Ziakka Vitamin D, the renin-angiotensin system, and insulin resistance Int Urol Nephrol 40 2008 419 426
69. A. Tomaschitz, S. Pilz, E. Ritz, T. Grammer, C. Drechsler, and B.O. Boehm Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study Clin Chim Acta 411 2010 1354 1360
70. J.P. Forman, J.S. Williams, and N.D. Fisher Plasma 25-hydroxyvitamin D and regulation of the renin-angiotensin system in humans Hypertension 55 2010 1283 1288
71. G. Rashid, J. Bernheim, J. Green, and S. Benchetrit Parathyroid hormone stimulates the endothelial expression of vascular endothelial growth factor Eur J Clin Invest 38 2008 798 803
72. I. Guessous, M. Bochud, O. Bonny, and M. Burnier Calcium, vitamin D and cardiovascular disease Kidney Blood Press Res 34 2011 404 417
73. J.L. Anderson, R.C. Vanwoerkom, B.D. Horne, T.L. Bair, H.T. May, and D.L. Lappé Parathyroid hormone, vitamin D, renal dysfunction, and cardiovascular disease: dependent or independent risk factors? Am Heart J 162 2011 331 339.e2
74. L.G. Danescu, S. Levy, and J. Levy Vitamin D and diabetes mellitus Endocrine 35 2009 11 17
75. A.G. Pittas, J. Lau, F.B. Hu, and B. Dawson-Hughes The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis J Clin Endocrinol Metab 92 2007 2017 2029 (Pubitemid 46997093)
76. K. Osei 25-OH vitamin D: is it the universal panacea for metabolic syndrome and type 2 diabetes? J Clin Endocrinol Metab 95 2010 4220 4222
77. J.G. Regensteiner, E.E. Wolfel, E.P. Brass, M.R. Carry, S.P. Ringel, and M.E. Hararten Chronic changes in skeletal muscle histology and function in peripheral arterial disease Circulation 87 1993 413 421 (Pubitemid 23040910)
78. V. Gilsanz, A. Kremer, A.O. Mo, T.A. Wren, and R. Kremer Vitamin D status and its relation to muscle mass and muscle fat in young women J Clin Endocrinol Metab 95 2010 1595 1601
79. J.N. Artaza, R. Mehrotra, and K.C. Norris Vitamin D and the cardiovascular system Clin J Am Soc Nephrol 4 2009 1515 1522
80. A. Zittermann, S.S. Schleithoff, and R. Koerfer Putting cardiovascular disease and vitamin D insufficiency into perspective Br J Nutr 94 2005 483 492 (Pubitemid 41555486)
81. H. Wasse, F. Cardarelli, C. De Staercke, C. Hooper, E. Veledar, and I. Guessous 25-Hydroxyvitamin D concentration is inversely associated with serum MMP-9 in a cross-sectional study of African American ESRD patients BMC Nephrol 12 2011 24
82. K. Müller, P.M. Haahr, M. Diamant, K. Rieneck, A. Kharazmi, and K. Bendtzen 1,25-Dihydroxyvitamin D3 inhibits cytokine production by human blood monocytes at the post-transcriptional level Cytokine 4 1992 506 512
83. 2 vitamin D inhibits foam cell formation and suppresses macrophage cholesterol uptake in patients with type 2 diabetes mellitus Circulation 120 2009 687 698
84. E.P. Carthy, W. Yamashita, A. Hsu, and B.S. Ooi 1,25-Dihydroxyvitamin D3 and rat vascular smooth muscle cell growth Hypertension 13 1989 954 959 (Pubitemid 19157996)
85. T.D. O'Connell, J.E. Berry, A.K. Jarvis, M.J. Somerman, and R.U. Simpson 1,25-Dihydroxyvitamin D3 regulation of cardiac myocyte proliferation and hypertrophy Am J Physiol 272 1997 H1751 H1758
86. K.E. Watson, M.L. Abrolat, L.L. Malone, J.M. Hoeg, T. Doherty, and R. Detrano Active serum vitamin D levels are inversely correlated with coronary calcification Circulation 96 1997 1755 1760 (Pubitemid 27400730)
87. A.C. Borges, T. Feres, L.M. Vianna, and T.B. Paiva Effect of cholecalciferol treatment on the relaxant responses of spontaneously hypertensive rat arteries to acetylcholine Hypertension 34 1999 897 901 (Pubitemid 29501320)
88. I. Al Mheid, R. Patel, J. Murrow, A. Morris, A. Rahman, and L. Fike Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans J Am Coll Cardiol 58 2011 186 192
89. M. Ohsawa, T. Koyama, K. Yamamoto, S. Hirosawa, S. Kamei, and R. Kamiyama 1alpha,25-dihydroxyvitamin D(3) and its potent synthetic analogs downregulate tissue factor and upregulate thrombomodulin expression in monocytic cells, counteracting the effects of tumor necrosis factor and oxidized LDL Circulation 102 2000 2867 2872
90. L. Wang, J.E. Manson, Y. Song, and H.D. Sesso Systematic review: vitamin D and calcium supplementation in prevention of cardiovascular events Ann Intern Med 152 2010 315 323
91. M.P. Marco, L. Craver, A. Betriu, M. Belart, J. Fibla, and E. Fernández Higher impact of mineral metabolism on cardiovascular mortality in a European hemodialysis population Kidney Int Suppl 2003 S111 S114
92. T. Shoji, K. Shinohara, E. Kimoto, M. Emoto, H. Tahara, and H. Koyama Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population Nephrol Dial Transplant 19 2004 179 184 (Pubitemid 38072630)
93. M. Teng, M. Wolf, M.N. Ofsthun, J.M. Lazarus, M.A. Hernán, and C.A. Camargo Jr. Activated injectable vitamin D and hemodialysis survival: a historical cohort study J Am Soc Nephrol 16 2005 1115 1125 (Pubitemid 41710323)
94. M. Wolf, A. Shah, O. Gutierrez, E. Ankers, M. Monroy, and H. Tamez Vitamin D levels and early mortality among incident hemodialysis patients Kidney Int 72 2007 1004 1013 (Pubitemid 47530570)
95. M. Naves-Díaz, D. Alvarez-Hernández, J. Passlick-Deetjen, A. Guinsburg, C. Marelli, and D. Rodriguez-Puyol Oral active vitamin D is associated with improved survival in hemodialysis patients Kidney Int 74 2008 1070 1078
96. D.P. Trivedi, R. Doll, and K.T. Khaw Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial BMJ 326 2003 469
97. R.L. Prince, N. Austin, A. Devine, I.M. Dick, D. Bruce, and K. Zhu Effects of ergocalciferol added to calcium on the risk of falls in elderly high-risk women Arch Intern Med 168 2008 103 108
98. J.L. Vacek, S.R. Vanga, M. Good, S.M. Lai, D. Lakkireddy, and P.A. Howard Vitamin D deficiency and supplementation and relation to cardiovascular health Am J Cardiol 109 2012 359 363
99. http://clinicaltrials.gov/ct2/results?term= vitamin+D+supplementation+cardiovascular+disease [accessed 3.2.12]
100. B. Dawson-Hughes Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women Am J Clin Nutr 80 2004 1763S 1766S
101. J.H. O'Keefe, C.J. Lavie, and M.F. Holick Vitamin D supplementation for cardiovascular disease prevention JAMA 306 2011 1546 1547
102. L. Mascitelli, M.R. Goldstein, and W.B. Grant Does vitamin D have a role in reducing the risk of peripheral artery disease? Mayo Clin Proc 85 2010 1058 1059
103. T. Toda, Y. Toda, and F.A. Kummerow Coronary arterial lesions in piglets from sows fed moderate excesses of vitamin D Tohoku J Exp Med 145 1985 303 310 (Pubitemid 15117726)
104. A. Zittermann, S.S. Schleithoff, and R. Koerfer Vitamin D and vascular calcification Curr Opin Lipidol 18 2007 41 46 (Pubitemid 46090236)