Pharmacokinetics of vitamin D toxicity

American Journal of Clinical Nutrition

Volumn 88, Issue 2, 2008, Pages

  Jones, Glenville ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

24,25 DIHYDROXYCOLECALCIFEROL; CALCIFEDIOL; CALCITRIOL; COLECALCIFEROL; VITAMIN D; VITAMIN D RECEPTOR;

ADIPOSE TISSUE; GENETIC TRANSCRIPTION; HUMAN; HYPERCALCEMIA; REVIEW; TISSUE DISTRIBUTION; VITAMIN D INTOXICATION; VITAMIN METABOLISM;

ANIMALIA;

EID: 49449114001     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/88.2.582s     Document Type: Review

References (44)

1. Jones G, Strugnell S, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998;78:1193-231.
2. 3. Semin Dial 2007;20:316-24.
3. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
4. Jones G. Vitamin D and analogues. In: Bilezikian JP, Raisz LG, Rodan GA, eds. Principles of bone biology. 3rd ed. San Diego, CA: Academic Press, 2008.
5. Prosser DE, Jones G. Enzymes involved in the activation and inactivation of vitamin D. Trends Biochem Sci 2004;29:664-73.
6. 3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) null mouse. Endocrinology 2005;146:825-34.
7. 3. Biochemistry 1979;18:3977-83.
8. Haddad JG, Matsuoka LY, Hollis BW, Hu YZ, Wortsman J. Human plasma transport of vitamin D after its endogenous synthesis. J Clin Invest 1993;91:2552-5.
9. Haddad JG Jr, Walgate J. 25-Hydroxyvitamin D transport in human plasma: isolation and partial characterization of calcifidiol-binding protein. J Biol Chem 1976;251:4803-9.
10. 3) and its metabolites with different genetic variants of the serum binding protein for these sterols. Biochem J 1979;179:413-23.
11. Mawer EB, Schaefer K, Lumb GA, Stanbury SW. The metabolism of isotopically labelled vitamin D3 in man: the influence of the state of vitamin D nutrition. Clin Sci 1971;40:39-53.
12. Jones G, Byford V, West S, et al. Hepatic activation and inactivation of clinically-relevant vitamin D analogs and prodrugs. Anticancer Res 2006;26:2589-96.
13. Jones G, Horst RL, Carter G, Makin HLJ. Measurement of 25-OH-D (RIA, HPLC, LC- MS/MS). J Bone Miner Res 2007;22(suppl):V11-V15.
14. Levine BS, Singer FR, Bryce GF, Mallon JP, Miller ON, Coburn JW. Pharmacokinetics and biologic effects of calcitriol in normal humans. J Lab Clin Med 1985;105:239-46.
15. Fakih MG, Trump DL, Muindi JR, et al. A phase I pharmacokinetic and pharmacodynamic study of intravenous calcitriol in combination with oral gefitinib in patients with advanced solid tumors. Clin Cancer Res 2007;13:1216-23.
16. 3-26,23- lactone. Proc Natl Acad Sci USA U S A 2007;104:12673-8.
17. Selby PL, Davies M, Marks J, Mawer EB. Vitamin D intoxication causes hypercalcaemia by increased bone resorption which responds to pamidronate. Clin Endocrinol (Oxf) 1995;43:531-6.
18. 3 intakes. Arch Biochem Biophys 1980;202:43-53.
19. 3 toxicity in dairy cows. J Dairy Sci 1982;65:749-59.
20. 3. Endocrinology 1982;111:2008-13.
21. 3 and its physiological implications. Steroids 1987;49:29-55.
22. 3 in growing dogs. Am J Physiol Endocrinol Metab 2003;284:E505-13.
23. 3 metabolites in horses. J Steroid Biochem Mol Biol 2004;89-90:595-600.
24. Counts SJ, Baylink DJ, Shen FH, Sherrard DJ, Hickman RO. Vitamin D intoxication in an anephric child. Ann Intern Med 1975;82:196-200.
25. Lilienfeld-Toal H, Messerschmidt W, Sturm B, Ochs H. 25-hydroxyvitamin D levels in a patient with hypervitaminosis D. Klin Wochenschr 1978;56:715-7.
26. Down PF, Polak A, Regan RJ. A family with massive acute vitamin D intoxication. Postgrad Med J 1979;55:897-902.
27. Jacqz E, Garabedian M, Guillozo H, et al. Circulating metabolites of vitamin D in 14 children with hypercalcemia. Arch Fr Pediatr 1985;42:225-30.
28. Besbas N, Oner A, Akhan O, Saatci U, Bakkaloglu A, Topaloglu R. Nephrocalcinosis due to vitamin D intoxication. Turk J Pediatr 1989;31:239-44.
29. Jacobus CH, Holick MF, Shao Q, et al. Hypervitaminosis D associated with drinking milk. N Engl J Med 1992;326:1173-7.
30. Rizzoli R, Stoermann C, Ammann P, Bonjour JP. Hypercalcemia and hyperosteolysis in vitamin D intoxication: effects of clodronate therapy. Bone 1994;15:193-8.
31. Chiricone D, De Santo NG, Cirillo M. Unusual cases of chronic intoxication by vitamin D. J Nephrol 2003;16:917-21.
32. Barrueto F Jr, Wang-Flores HH, Howland MA, Hoffman RS, Nelson LS. Acute vitamin D intoxication in a child. Pediatrics 2005;116:e453-6.
33. Klontz KC, Acheson DW. Dietary supplement-induced vitamin D intoxication. N Engl J Med 2007;357:308-9.
34. Vieth R. The mechanisms of vitamin D toxicity. Bone Miner 1990;11:267-72.
35. Blank S, Scanlon KS, Sinks TH, Lett S, Falk H. An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. Am J Public Health 1995;85:656-9.
36. Pettifor JM, Bikle DD, Cavaleros M, Zachen D, Kamdar MC, Ross FP. Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Ann Intern Med 1995;122:511-3.
37. Adams JS, Singer FR, Gacad MA, et al. Isolation and structural identification of 1,25-dihydroxyvitamin D3 produced by cultured alveolar macrophages in sarcoidosis. J Clin Endocrinol Metab 1985;60:960-6.
38. O'Leary TJ, Jones G, Yip A, Lohnes D, Cohanim M, Yendt ER. The effects of chloroquine on serum 1,25-dihydroxyvitamin D and calcium metabolism in sarcoidosis. N Engl J Med 1986;315:727-30.
39. Inui N, Murayama A, Sasaki S, et al. Correlation between 25-hydroxyvitamin D3 1α-hydroxylase gene expression in alveolar macrophages and the activity of sarcoidosis. Am J Med 2001;110:687-93.
40. Brown AJ, Dusso AS, Slatopolsky E. Vitamin D analogues for secondary hyperparathyroidism. Nephrol Dial Transplant 2002;17(suppl):10-9.
41. 3 occurs through the vitamin D receptor and the vitamin D-responsive element. J Bone Miner Res 1994;9:1981-7.
42. Haussler MR, Whitfield GK, Haussler CA, et al. The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res 1998;13:325-49.
43. Bikle DD, Gee E. Free, and not total, 1,25-dihydroxyvitamin D regulates 25-hydroxyvitamin D metabolism by keratinocytes. Endocrinology 1989;124:649-54.
44. Bikle DD, Gee E, Halloran B, Kowalski MA, Ryzen E, Haddad JG. Assessment of the free fraction of 25-hydroxyvitamin D in serum and its regulation by albumin and the vitamin D-binding protein. J Clin Endocrinol Metab 1986;63:954-9.