Parathyroid hormone stimulates the endothelial expression of vascular endothelial growth factor

European Journal of Clinical Investigation

Volumn 38, Issue 11, 2008, Pages 798-803

  Rashid, G ^b   Bernheim, J ^a,b,c   Green, J ^b   Benchetrit, S ^b,c  

^a MEIR MEDICAL CENTER   (Israel)

^b Meir Medical Center   (Italy)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Endothelial cells; PKA; PKC; PTH; VEGF

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PARATHYROID HORMONE; PROTEIN KINASE C INHIBITOR; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL CORD; UMBILICAL VEIN;

CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; NG-NITROARGININE METHYL ESTER; PARATHYROID HORMONE; PROTEIN KINASE C; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UMBILICAL VEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 54349126907     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2008.02033.x     Document Type: Article

References (34)

1. Rostand SG, Drueke TB. Parathyroid hormone, vitamin D, and cardiovascular disease in chronic renal failure. Kidney Int 1999 56 : 383 92.
2. Brown EM. Homeostatic mechanisms regulating extracellular and intracellular calcium metabolism. In : Bilezikian JP, Levine MA, Marcus R, eds. The Parathyroids. New York : Raven, 1994.
3. Jiang B, Morimoto S, Yang J, Niinoabu T, Fukuo K, Ogihara T. Expression of parathyroid hormone/parathyroid hormone-related protein receptor in vascular endothelial cells. J Cardiovas Pharm 1998 31 (S1 S142 4.
4. Isales CM, Sumpio B, Bollag RJ, Zhong Q, Ding KH, Du W et al. Functional parathyroid hormone receptors are present in an umbilical vein endothelial cell line. Am J Physiol Endocrinol Metab 2000 279 : E654 62.
5. Bro S, Olgaard K. Effect of excess PTH on nonclassical target organs. AM J Kidney Dis 1997 30 : 606 20.
6. Rashid G, Bernheim J, Green J, Benchetrit S. Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways. Am J Physiol Renal Physiol 2007 292 : F1215 8.
7. Rashid G, Bernheim J, Green J, Benchetrit S. Parathyroid hormone stimulates the endothelial nitric oxide synthase through protein kinase A and C pathways. Nephrol Dial Transplant 2007 22 : 2831 7.
8. Inoue M, Itoh H, Ueda M, Naruko T, Kojima A, Komatsu R et al. Vascular endothelial growth factor (VEGF) expression in human coronary atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation 1998 98 : 1998.
9. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997 18 : 4 25.
10. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003 9 : 669 76.
11. Ladoux A, Frelin C. Expression of vascular endothelial growth factor by cultured endothelial cells from brain microvessels. Biochem Biophys Res Commun 1993 194 : 799 803.
12. Namiki A, Brogi E, Kearney M, Kim EA, Wu T, Couffinhal T et al. Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells. J Biol Chem 1995 270 : 31189 95.
13. Imaizumi T, Itaya H, Nasu S, Yoshida H, Matsubara Y, Fujimoto K et al. Expression of vascular endothelial growth factor in human umbilical vein endothelial cells stimulated with interleukin-1alpha-an autocrine regulation of angiogenesis and inflammatory reactions. Thromb Haemost 2000 83 : 949 55.
14. Yoon JS, Kim HH, Han JW, Lee Y, Lee JS. Effects of intravenous immunoglobulin and methylprednisolone on human umbilical vein endothelial cells in vitro. Immunobiology 2006 211 : 351 7.
15. Ferrara N, Winer J, Burton T. Aortic smooth muscle cells express and secrete vascular endothelial growth factor. Growth Factors 1991 5 : 141 8.
16. Adamis AP, Miller JW, Bernal MT, D'Amico DJ, Folkman J, Yeo TK et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol 1994 118 : 445 50.
17. Cha DR, Kim NH, Yoon JW, Jo SK, Cho WY, Kim HK et al. Role of vascular endothelial growth factor in diabetic nephropathy. Kidney Int Suppl 2000 77 : S104 12.
18. Poltorak Z, Cohen T, Neufeld G. The VEGF splice variants: properties, receptors, and usage for the treatment of ischemic diseases. Herz 2000 25 : 126 9.
19. Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 1991 5 : 1806 14.
20. Keyt BA, Berleau LT, Nguyen HV, Chen H, Heinsohn H, Vandlen R et al. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem 1996 271 : 7788 95.
21. Rashid G, Benchetrit S, Fishman D, Bernheim J. Effect of Advanced Glycation End Products (AGEs) on gene expression and synthesis of TNF-α and endothelial nitric oxide synthase by endothelial cells. Kidney Int 2004 66 : 1099 106.
22. Yonemitsu Y, Kaneda Y, Morishita R, Nakagawa K, Nakashima Y, Sueishi K. Characterization of in vivo gene transfer into the arterial wall mediated by the Sendai virus (hemagglutinating virus of Japan) liposomes: an effective tool for the in vivo study of arterial diseases. Lab Invest 1996 75 : 313 23.
23. Lazarous DF, Shou M, Scheinowitz M, Hodge E, Thirumurti V, Kitsiou AN et al. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. Circulation 1996 94 : 1074 82.
24. Dulak J, Jozkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000 20 : 659 66.
25. Perkovic V, Hewitson TD, Kelynack KJ, Matic M, Tait MG, Becker GJ. Parathyroid hormone has a prosclerotic effect on vascular smooth muscle cells. Kidney Blood Press Res 2003 26 : 27 33.
26. Dvorak HF, Brown LF, Detmar M, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995 146 : 1029 39.
27. Clauss M, Gerlach M, Gerlach H, Brett J, Wang F, Familletti PC et al. Vascular permeability factor: a tumour-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 1990 172 : 1535 45.
28. Celletti FL, Waugh JM, Amabile PG, Brendolan A, Hilfiker PR, Dake MD. Vascular endothelial growth factor enhances atherosclerotic plaque progression. Nat Med 2001 7 : 425 9.
29. Tenaglia AN, Peters KG, Sketch MH Jr., Annex BH. Neovascularization in atherectomy specimens from patients with unstable angina: implications for pathogenesis of unstable angina. Am Heart J 1998 135 : 10 4.
30. Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, Desai S et al. Autocrine VEGF signalling is required for vascular homeostasis. Cell 2007 130 : 691 703.
31. Potts JT, Juppner H. Parathyroid hormone and parathyroid hormone-related peptide in calcium homeostasis, bone metabolism and bone development: the proteins, their genes and receptors. In : Avioli LV, Krane SM, eds. Metabolic Bone Disease. New York : Academic, 1997, pp. 51 94.
32. Segre GV. Receptors for parathyroid hormone and parathyroid hormone-related protein. In : Bilezikian JP, Raisz LG, Rodan GA, eds. Principles in Bone Biology. New York : Academic 1996, pp. 377 403.
33. Dulak J, Jozkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D et al. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000 20 : 659 66.
34. Jozkowicz A, Cooke JP, Guevara I, Huk I, Funovics P, Pachinger O et al. Genetic augmentation of nitric oxide synthase increases the vascular generation of VEGF. Cardiovasc Res 2001 51 : 773 83.