Vitamin D and vascular calcification

Current Opinion in Lipidology

Volumn 18, Issue 1, 2007, Pages 41-46

  Zittermann, Armin ^a   Schleithoff, Stefanie S ^a   Koerfer, Reiner ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Calcification; Calcitriol; Calcium; Renal insufficiency; Vitamin D

Indexed keywords

CALCITRIOL; CALCIUM; CELL ADHESION MOLECULE; PARICALCITOL; VITAMIN D; VITAMIN D DERIVATIVE;

ARTERY CALCIFICATION; ARTERY INTIMA; ARTERY MEDIA; BLOOD VESSEL CALCIFICATION; CELL MIGRATION; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; CYTOKINE RELEASE; DIALYSIS; HORMONE BLOOD LEVEL; HUMAN; HYPERPARATHYROIDISM; INFLAMMATION; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SMOOTH MUSCLE FIBER; UREMIA; VITAMIN D DEFICIENCY;

ANIMALS; CALCINOSIS; DISEASE MODELS, ANIMAL; HOMEOSTASIS; HUMANS; MODELS, BIOLOGICAL; VASCULAR DISEASES; VITAMIN D; VITAMIN D DEFICIENCY;

RATTUS;

EID: 33846152278     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e328011c6fc     Document Type: Review

References (50)

1. Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003; 89:552-572.
2. Speeckaert M, Huang G, Delanghe JR, et al. Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 2006; 372:33-42. This comprehensive review demonstrates that vitamin D binding protein has important functional properties beside its carrier function for vitamin D metabolites.
3. Raymond MA, Desormeaux A, Labelle A, et al. Endothelial stress induces the release of vitamin D-binding protein, a novel growth factor. Biochem Biophys Res Commun 2005; 338:1374-1382. This interesting experimental study that gave new insight in possible mechanisms of vascular injury.
4. Towler DA, Clemens TL. Vitamin D and cardiovascular medicine. In: Feldman D, Pike JW, Glorieux FH, editors. Vitamin D, 2nd edition. Amsterdam: Elsevier Academic Press; 2005. pp. 899-910.
5. Moon J, Bandy B, Davison AJ. Hypotheis: are imbalances in the calciferol endocrine system implicated? J Amer Coll Nutr 1992; 11:567-583.
6. Price PA, Faus SA, Williamson MK. Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arterioscler Thromb Vasc Biol 2001; 21:817-824.
7. Banks LM, Lees B, MacSweeney JE, et al. Effect of degenerative spinal and aortic calcification on bone density measurements in postmenopausal women: links between osteoporosis and cardiovascular disease? Eur J Clin Invest 1994; 24:813-817.
8. Barengolts EI, Berman M, Kukreja SC, et al. Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int 1998; 62:209-213.
9. Honye J, Mahon DJ, Jain A, et al. Morphological effects of coronary balloon angioplasty in vivo assessed by intravascular ultrasound imaging. Circulation 1992; 85:1012-1025.
10. Margolis JR, Chen JT, Kong Y, et al. The diagnostic and prognostic significance of coronary artery calcification. A report of 800 cases. Radiology 1980; 137:609-616.
11. Foley RN, Parfrey PS, Sarnaak MJ. Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 1998; 32 (5 Suppl 3):S112-S119.
12. Doherty TM, Fitzpatric LA, Inoue D, et al. Molecular, endocrine, and genetic mechanisms of arterial calcification. Endocr Rev 2004; 25:629-672.
13. Tomasek JJ, Gabbiani G, Hinz B, et al. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3:349-363.
14. Basalyga DM, Simionescu DT, Xiong W, et al. Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinases. Circulation 2004; 110:3480-3487.
15. Qin X, Corriere MA, Matrisian LM, et al. Matrix metalloproteinase inhibition attenuates aortic calcification. Arterioscler Thromb Vasc Biol 2006; 26:1510-1516. This was another interesting experimental study providing evidence that vascular calcification and also its inhibition is an actively regulated process.
16. London GM, Marty C, Marchais SJ, et al. Arterial calcifications and bone histomorphometry in end-stage renal disease. J Am Soc Nephrol 2004; 15:1943-1951.
17. Schinke T, Karsenty G. Vascular calcification: a passive process in need of inhibitors. Nephrol Dial Transplant 2000; 15:1272-1274.
18. Block GA, Hulbert-Shearon TE, Levin NW, et al. Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: a national study. Am J Kidney Dis 1998; 31:607-617.
19. Wu-Wong JR, Noonan W, Ma J, et al. Role of phosphorus and vitamin D analogs in the pathogenesis of vascular calcification. J Pharmacol Exp Ther 2006; 318:90-98. Extensively performed in-vivo and ex-vivo studies provided evidence that vascular calcification in vivo cannot be easily replicated in ex-vivo or in-vitro models.
20. Lomashvili K, Garg P, O'Neill WC. Chemical and hormonal determinants of vascular calcification in vitro. Kidney Int 2006; 69:1464-1470. Authors used a new model of vascular calcification in chronic renal failure to study the effects of possible risk factors.
21. Niederhoffer N, Lartaud-Idjouadiene I, Giummelly P, et al. Calcification of medial elastic fibers and aortic elasticity. Hypertension 1997; 29:999-1006.
22. Bas A, Lopez I, Perez J, et al. Reversibility of calcitriol-induced medial artery calcification in rats with intact renal function. J Bone Miner Res 2006; 21:484-490. This study in experimental animals is of clinical importance because it demonstrated the reversibility of vascular calcification.
23. Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr 2005; 94:483-492. This comprehensive review provides several lines of evidence for an association of vitamin D insufficiency with cardiovascular disease.
24. Haffner D, Hocher B, Müller D, et al. Systemic cardiovascular disease in uremic rats induced by 1,25(OH)2D3. J Hypertens 2005; 23:1067-1075.
25. Henley C, Colloton M, Cattley RC, et al. 1,25-Dihydroxyvitamin D3 but not cinacalcet HCl (Sensipar/Mimpara) treatment mediates aortic calcification in a rat model of secondary hyperparathyroidism. Nephrol Dial Transplant 2005; 20:1370-1377.
26. Tamagaki K, Yuan Q, Ohkawa H, et al. Severe hyperparathyroidism with bone abnormalities and metastatic calcification in rats with adenine-induced uraemia. Nephrol Dial Transplant 2006; 21:651-659. Another important investigation in experimental animals supported the hypothesis that calitriol deficiency is involved in vascular calcification.
27. Wu-Wong JR, Nakane M, Ma J, et al. Effects of vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells. Atherosclerosis 2006; 186:20-28. An important investigation demonstrated that gene activation and deactivation by vitamin D plays a central role in the metabolism of arterial smooth muscle cells.
28. Aihara K, Azuma H, Akaike M, et al. Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice. J Biol Chem 2004; 279:35798-35802.
29. Zehnder D, Bland R, Chana RS, et al. Synthesis of 1,25-dihydroxyvitamin D(3) by human endothelial cells is regulated by inflammatory cytokines: a novel autocrine determinant of vascular cell adhesion. J Am Soc Nephrol 2002; 13:621-629.
30. Equils O, Naiki Y, Shapiro AM, et al. 1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin Exp Immunol 2005; 45:58-64. The authors describe several well performed ex-vivo experiments that provide evidence for protective effects of calcitriol on endothelial cells.
31. Martinesi M, Bruni S, Stio M, et al. 1,25-Dihydroxyvitamin D3 inhibits tumor necrosis factor-alpha-induced adhesion molecule expression in endothelial cells. Cell Biol Int 2006; 30:365-375. Well performed experimental studies gave new insights in the beneficial effects of vitamin D on endothelial cells.
32. Nakagawa K, Sasaki Y, Kato S, et al. 22-Oxa-1alpha,25- dihydroxyvitamin D3 inhibits metastasis and angiogenesis in lung cancer. Carcinogenesis 2005; 26:1044-1054.
33. Bao BY, Yeh SD, Lee YF. 1α,25-dihydroxyvitamin D3 inhibits prostate cancer cell invasion via modulation of selective proteases. Carcinogenesis 2006; 27:32-42. Although from studies performed in prostate cancer cells, these experimental data support the central role of vitamin D in the regulation of cellular processes.
34. Timms PM, Mannan N, Hitman GA, et al. Circulating MMP9, vitamin D and variation in the TIMP-1 response with VDR genotype: mechanisms for inflammatory damage in chronic disorders? QJM 2002; 95:787-796.
35. Briese S, Wiesner S, Will JC, et al. Arterial and cardiac disease in young adults with childhood-onset end-stage renal disease-impact of calcium and vitamin D therapy. Nephrol Dial Transplant 2006; 21:1906-1914. This case-control study indicated that active vitamin D preparations are independently associated in a dose-dependent manner with cardiovascular disease. Data support the assumption that the therapeutic window for active vitamin D may be narrow in patients with chronic kidney disease.
36. Juttmann JR, Buurman CJ, DeKam E, et al. Serum concentrations of metabolites of vitamin D in patients with chronic renal failure. Clin Endocrinol 1981; 14:225-236.
37. Fukagawa M, Kurokawa K. Renal failure and secondary hyperparathyroidism. In: Feldman D, Pike JW, Glorieux FH, editors. Vitamin D, 2nd edition. Amsterdam: Elsevier, Academic Press, Amsterdam; 2005. pp. 1820-11832.
38. Qunibi WJ, Abouzahr F, Mizani MR, et al. Cardiovascular calcification in Hispanic Americans (HA) with chronic kidney disease (CKD) due to type 2 diabetes. Kidney Int 2005; 68:271-277.
39. Al Humoud H, Al-Hilali N, Ahmad AAMH, et al. Vascular calcification in dialysis patients. Transplant Proc 2005; 37:4183-4186. This epidemiological investigation compared several possible risk factors for vascular calcification in two groups of dialysis patients.
40. Halloran BP, Schaefer P, Lifschitz M, et al. Plasma vitamin D metabolite concentrations in chronic renal failure: effect of oral administration of 25-hydroxyvitamin D3. J Clin Endocrinol Metab 1984; 59:1063-1069.
41. LaClair RE, Heilman RN, Karp SL, et al. Prevalence of calcidiol deficiency in CKD: a cross-sectional study across latitudes in the United States. Am J Kidney Dis 2005; 45:1026-1033.
42. Monge M, Shahapuni I, Harbouche L, et al. Cinacalcet and vascular calcifications induced by calcitriol. Nephrol Dial Transplant 2006; 21:551. This is a letter to the editor that provides arguments for calcidiol repletion in uremic patients.
43. Nakai S, Shinzato T, Nagura Y, et al. An overview of regular dialysis treatment in Japan (as of 31 December 2001). Ther Apher Dial 2004; 8:3-32.
44. Teng M, Wolf M, Ofsthun MN, et al. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol 2005; 16:1115-1125.
45. Shoji T, Shinohara K, Kimoto E, et al. Lower risk for cardiovascular mortality in oral 1alpha-hydroxy vitamin D3 users in a haemodialysis population. Nephrol Dial Transplant 2004; 19:179-184.
46. Teng M, Wolf M, Lowrie E, et al. Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med 2003; 349:446-456.
47. Zochling J, Chen JS, Seibel M, et al. Calcium metabolism in the frail elderly. Clin Rheumatol 2005; 24:576-582. This epidemiological study demonstrated the high prevalence of mild renal impairment and vitamin D insufficiency in frail elderly subjects.
48. Watson KE, Abrolat ML, Malone LL, et al. Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation 1997; 96:1755-1760.
49. Schleithoff SS, Zittermann A, Tenderich G, et al. Vitamin D supplementation improves cytokine profile in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 2006; 83:754-759. This important prospective study demonstrated that oral vitamin D intake is able to suppress pro-inflammatory cytokines and to enhance anti-inflammatory cytokines.
50. Mallat Z, Besnard S, Duriez M, et al. Protective role of interleukin-10 in atherosclerosis. Circ Res 1999; 85:e17-e24.