The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response

Oncogene

Volumn 31, Issue 45, 2012, Pages 4803-4809

  Lemaitre C ^a   Fischer, B ^a   Kalousi, A ^a   Hoffbeck, A S ^a   Guirouilh Barbat, J ^b   Shahar, O D ^c   Genet, D ^b   Goldberg, M ^c   Betrand, P ^b   Lopez, B ^b   Brino, L ^a   Soutoglou, E ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b INSTITUT DE RADIOBIOLOGIE CELLULAIRE ET MOLÉCULAIRE   (France)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; NUCLEOPORIN; NUCLEOPORIN 153; PROTEIN A; UNCLASSIFIED DRUG;

ARTICLE; CELL COMPARTMENTALIZATION; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; MITOSIS; NUCLEAR PORE COMPLEX; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA END-JOINING REPAIR; DNA REPAIR; HOMOLOGOUS RECOMBINATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NUCLEAR PORE COMPLEX PROTEINS; PROTEIN TRANSPORT; RNA INTERFERENCE;

EID: 84869093574     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.638     Document Type: Article

References (27)

1. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461: 1071-1078.
2. Misteli T, Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol 2009; 10: 243-254.
3. Bartek J, Lukas J. DNA damage checkpoints: from initiation to recovery or adaptation. Curr Opin Cell Biol 2007; 19: 238-245. (Pubitemid 46386406)
4. Lisby M, Mortensen UH, Rothstein R. Colocalization of multiple DNA doublestrand breaks at a single Rad52 repair centre. Nat Cell Biol 2003; 5: 572-577. (Pubitemid 36781093)
5. Nagai S, Dubrana K, Tsai-Pflugfelder M, Davidson MB, Roberts TM, Brown GW et al. Science 2008; 322: 597-602.
6. Oza P, Jaspersen SL, Miele A, Dekker J, Peterson CL. Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery. Genes & Development 2009; 23: 912-927.
7. Loeillet S, Palancade Bt, Cartron M, Thierry As, Richard G-F, Dujon B et al. Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast. DNA Repair 2005; 4: 459-468. (Pubitemid 40267704)
8. Bermejo R, Capra T, Jossen R, Colosio A, Frattini C, Carotenuto W et al. The Replication Checkpoint Protects Fork Stability by Releasing Transcribed Genes from Nuclear Pores. Cell 2011; 146: 233-246.
9. Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T et al. Nat Cell Biol 2007; 9: 675-682.
10. Weinstock DM, Nakanishi K, Helgadottir HR, Jasin M. Assaying Double-Strand Break Repair Pathway Choice in Mammalian Cells Using a Targeted Endonuclease or the RAG Recombinase. Methods Enzymol 2006; 409: 524-540.
11. Miller KM, Tjeertes JV, Coates J, Legube G, Polo SE, Britton S et al. Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. Nat Struct Mol Biol 2010; 17: 1144-1151.
12. Rass E, Grabarz A, Plo I, Gautier J, Bertrand P, Lopez BS. Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells. Nat Struct Mol Biol 2009; 16: 819-824.
13. Guirouilh-Barbat Je, Huck S, Bertrand P, Pirzio L, Desmaze C, Sabatier L et al. Molecular Cell 2004; 14: 611-623.
14. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A et al. Molecular Cell 2007; 28: 1045-1057.
15. Yoshida M, Horinouchi S. Trichostatin and Leptomycin: Inhibition of Histone Deacetylation and Signal-Dependent Nuclear Export. Ann N Y Acad Sci 1999; 886: 23-35.
16. Walther TC, Fornerod M, Pickersgill H, Goldberg M, Allen TD, Mattaj IW. The nucleoporin Nup153 is required for nuclear pore basket formation, nuclear pore complex anchoring and import of a subset of nuclear proteins. EMBO J 2001; 20: 5703-5714. (Pubitemid 33010047)
17. Moudry P, Lukas C, Macurek L, Neumann B, Heriche J-K, Pepperkok R et al. Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1. Cell Death Differ 2011 (e-pub ahead of print 11 November 2011; doi:10.1038/cdd.2011.150).
18. Bunting SF, Calle'n E, Wong N, Chen H-T, Polato F, Gunn A et al. 53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks. Cell 2010; 141: 243-254.
19. Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, van der Gulden H et al. 53BP1 loss rescues BRCA1 deficiency and is associated with triplenegative and BRCA-mutated breast cancers. Nat Struct Mol Biol 2010; 17: 688-695.
20. Mochan TA, Venere M, DiTullio RA, Halazonetis TD. 53BP1 and NFBD1/MDC1-Nbs1 Function in Parallel Interacting Pathways Activating Ataxia-Telangiectasia Mutated (ATM) in Response to DNA Damage. Cancer Res 2003; 63: 8586-8591. (Pubitemid 38064030)
21. Lee J-H, Goodarzi AA, Jeggo PA, Paull TT. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J 2010; 29: 574-585.
22. Noon AT, Shibata A, Rief N, Lobrich M, Stewart GS, Jeggo PA et al. 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol 2010; 12: 177-184.
23. Minter-Dykhouse K, Ward I, Huen MSY, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol 2008; 181: 727-735. (Pubitemid 351786979)
24. Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER, Hurov KE, Luo J et al. ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage. Science 2007; 316: 1160-1166. (Pubitemid 46877472)
25. Palancade B, Liu X, Garcia-Rubio M, Aguilera As, Zhao X, Doye Vr. Nucleoporins Prevent DNA Damage Accumulation by Modulating Ulp1-dependent Sumoylation Processes. Mol Biol Cell 2007; 18: 2912-2923. (Pubitemid 47235299)
26. Soutoglou E, Misteli T. Activation of the cellular DNA damage response in the absence of DNA lesions. Science 2008; 320: 1507-1510. (Pubitemid 351929432)
27. Reddy KL, Singh H. Using molecular tethering to analyze the role of nuclear compartmentalization in the regulation of mammalian gene activity. Methods 2008; 45: 242-251.