Cleistanthoside A tetraacetate-induced DNA damage leading to cell cycle arrest and apoptosis with the involvement of p53 in lung cancer cells

European Journal of Pharmacology

Volumn 696, Issue 1-3, 2012, Pages 35-42

  Wanitchakool, Podchanart ^a   Jariyawat, Surawat ^a   Suksen, Kanoknetr ^a   Soorukram, Darunee ^a   Tuchinda, Patoomratana ^a   Piyachaturawat, Pawinee ^a  

^a Mahidol University   (Thailand)

Author keywords

Apoptosis; Cleistanthoside A tetraacetate; G1 arrest; Lung cancer cell; p53

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CLEISTANTHOSIDE A; CLEISTANTHOSIDE A TETRAACETIC ACID; CYCLIN D1; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG CANCER; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOFURANS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; DISACCHARIDES; DNA DAMAGE; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; HUMANS; LUNG NEOPLASMS; PHYLLANTHUS; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84869081134     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.09.029     Document Type: Article

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