Binding of etoposide to topoisomerase II in the absence of DNA: Decreased affinity as a mechanism of drug resistance

Biochemistry

Volumn 38, Issue 12, 1999, Pages 3457-3461

  Kingma, Paul S ^a   Burden, D Andrew ^a   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE;

ARTICLE; BINDING AFFINITY; CANCER CHEMOTHERAPY; DRUG BINDING; DRUG BINDING SITE; DRUG EFFICACY; DRUG RESISTANCE; DRUG TARGETING; ENZYME BINDING; NONHUMAN; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BINDING SITES; BINDING, COMPETITIVE; DNA; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; MUTATION; SACCHAROMYCES CEREVISIAE; TYROSINE;

EID: 18544393471     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982855i     Document Type: Article

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