D11, a novel glycosylated diphyllin derivative, exhibits potent anticancer activity by targeting topoisomerase IIα

Investigational New Drugs

Volumn 29, Issue 5, 2011, Pages 800-810

  Gui, Min ^a   Shi, Da Kuo ^b   Huang, Min ^a   Zhao, Yu ^b   Sun, Qi Ming ^a   Zhang, Jing ^a   Chen, Qin ^a   Feng, Jian Ming ^a   Liu, Chun Hong ^b   Li, Ming ^a   Li, Ying Xia ^b   Geng, Meiyu ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b OCEAN UNIVERSITY OF CHINA   (China)

Author keywords

Diphyllin; Glycosides; Topoisomerase II ATPase; Topoisomerase II inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; D 11; DIPROPHYLLINE; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; GYRASE INHIBITOR; SUGAR; TOPOISOMERASE II ALPHA; UNCLASSIFIED DRUG; 1,3 DIOXOLANE DERIVATIVE; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; D11 COMPOUND; DNA; DNA BINDING PROTEIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE II ALPHA; GLUCOSIDE; LIGNAN; TUMOR ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; BREAST CARCINOMA; CANCER INHIBITION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACETYLATION; DRUG CONFORMATION; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ENZYME BINDING; ENZYME INHIBITION; FEMALE; GLYCOSYLATION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROLYSIS; IC 50; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; LIVER CELL CARCINOMA; LUNG FIBROBLAST; MELANOMA; MOUSE; MOUTH SQUAMOUS CELL CARCINOMA; NONHUMAN; OVARY ADENOCARCINOMA; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROSTATE CARCINOMA; STOMACH ADENOCARCINOMA; STRUCTURE ACTIVITY RELATION; TREATMENT RESPONSE; TUMOR XENOGRAFT; UMBILICAL VEIN ENDOTHELIAL CELL; WEIGHT REDUCTION; ANIMAL; BAGG ALBINO MOUSE; BIOCATALYSIS; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; METABOLISM; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOCATALYSIS; CELL LINE, TUMOR; DIOXOLANES; DNA; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; FEMALE; GLUCOSIDES; GLYCOSYLATION; HUMANS; HYDROLYSIS; LIGNANS; MICE; MICE, INBRED BALB C; TOPOISOMERASE II INHIBITORS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84855768356     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9425-3     Document Type: Article

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