Quantification of ginsenosides Rh4 and Rk3 in rat plasma by liquid chromatography-tandem mass spectrometry: Application to a pre-clinical pharmacokinetic study

Journal of Mass Spectrometry

Volumn 47, Issue 11, 2012, Pages 1510-1517

  Patel, Dhavalkumar Narendrabhai ^a   Lin, Hai Shu ^a   Koh, Hwee Ling ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

ginsenoside Rh4; ginsenoside Rk3; LC ESI MS MS; pharmacokinetics; steam processed ginseng

Indexed keywords

ACTIVE SUBSTANCE; GINSENOSIDES; INTRAVENOUS ADMINISTRATION; ION MONITORING; IONIZATION MODES; LC/ESI/MS/MS; LC/MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MEDICINAL APPLICATIONS; MULTIPLE REACTION MONITORING; ORAL ADMINISTRATION; PHARMACOKINETIC PROFILES; PHARMACOKINETIC STUDIES; PLASMA EXPOSURE; PRE-CLINICAL; RAT PLASMA; RELATIVE STANDARD DEVIATIONS; SPRAGUE-DAWLEY RATS;

BIOCHEMISTRY; BODY FLUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

PHARMACOKINETICS;

GINSENOSIDE; GINSENOSIDE RH 4; GINSENOSIDE RK 3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION MONITORING; LIQUID CHROMATOGRAPHY; MALE; MONITORING; MULTIPLE REACTION MONITORING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GINSENOSIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

PANAX; PANAX GINSENG; RATTUS;

EID: 84869071887     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3095     Document Type: Article

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