Inhibitory activity of ginsenosides isolated from processed ginseng on platelet aggregation

Pharmazie

Volumn 65, Issue 7, 2010, Pages 520-522

  Lee, Jin Gyun ^a   Lee, Yong Yook ^a   Wu, Bo ^a   Kim, Sun Young ^a   Lee, Yong Jae ^a   Yun Choi, Hye Sook ^a   Park, Jeong Hill ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLSALICYLIC ACID; ADENOSINE DIPHOSPHATE; ANTITHROMBOCYTIC AGENT; ARACHIDONIC ACID; COLLAGEN; GINSENOSIDE; GINSENOSIDE F 4; GINSENOSIDE RG 6; GINSENOSIDE RH 4; GINSENOSIDE RK 3; GINSENOSIDE RS 3; GINSENOSIDE RS 4; GINSENOSIDE RS 5; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACETYLATION; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG ISOLATION; DRUG SCREENING; GINSENG; IC 50; INHIBITION KINETICS; MALE; NONHUMAN; RAT; THROMBOCYTE AGGREGATION INHIBITION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ACETYLATION; ADENOSINE DIPHOSPHATE; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLLAGEN; GINSENOSIDES; MALE; PANAX; PLANT EXTRACTS; PLANT ROOTS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SPECTROPHOTOMETRY, ULTRAVIOLET; VASOCONSTRICTOR AGENTS;

EID: 77955366413     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.9786     Document Type: Article

References (15)

1. Born GV, Cross MJ (1963) The aggregation of blood platelets. J Physiol (Lond) 168: 178-195.
2. Kim SE, Lee YH, Park JH, Lee SK (1999a) Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells. Anticancer Res 19: 487-491.
3. Kim SE, Lee YH, Park JH, Lee SK (1999b) Ginsenoside-Rs4, a new type of ginseng saponin concurrently induces apoptosis and selectively elevates protein levels of p53 and p21WAF1 in human hepatoma SK-HEP-1 cells. Eur J Cancer 35: 507-511.
4. Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK, Kim CK, Park JH (2000) Steaming of ginseng at high temperature enhances biological activity. J Nat Prod 63: 1702-1704.
5. Kuo SC, Teng CM, Lee JC, Ko FN, Chen SC, Wu TS (1990) Antiplatelet components in Panax ginseng. Planta Med 56: 164-167.
6. Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH (2001) Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A 921: 335-339.
7. Lee JG, Lee YY, Kim SY, Pyo JS, Yun-Choi HS, Park JH (2009) Platelet antiaggregating activity of ginsenosides isolated from processed ginseng. Pharmazie 64: 602-604.
8. Lee SR, Park JH, Choi KJ, Kim ND (1997) Inhibitory effects of ginsenoside Rg3 on platelet aggregation and its mechanism of action. Korean J Ginseng Sci 21: 132-140.
9. Matsuda H, Namba K, Fukuda S, Tani T, Kubo M (1986) Pharmacological study on Panax ginseng C. A. Meyer. III. Effects of red ginseng on experimental disseminated intravascular coagulation. (2). Effects of ginsenosides on blood coagulative and fibrinolytic systems. Chem Pharm Bull 34: 1153-1157.
10. Park IH, Han SB, Kim JM, Piao LZ, Kwon SW, Kim NY, Kang TL, Park MK, Park JH (2002a) Four new acetylated ginsenosides from processed ginseng (sun ginseng). Arch Pharm Res 25: 837-841.
11. Park IH, Kim NY, Han SB, Kim JM, Kwon SW, Kim HJ, Park MK, Park JH (2002b) Three new dammarane glycosides from heat processed ginseng. Arch Pharm Res 25: 428-432.
12. Park IH, Paio LZ, Kwon SW, Lee YJ, Cho SY, Park MK, Park JH (2002c) Cytotoxic dammarane glycosides from processed ginseng. Chem Pharm Bull 50: 538-540.
13. Pyo MK, Lee Y, Yun-Choi HS (2002) Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata. Arch Pharm Res 25: 325-328.
14. Teng CM, Kuo SC, Ko FN, Lee JC, Lee LG, Chen SC, Huang TF (1989) Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. Biochim Biophys Acta 990: 315-320.
15. Yu JY, Jin YR, Lee JJ, Chung JH, Noh JY, You SH, Kim KN, Im JH, Lee JH, Seo JM, Han HJ, Lim Y, Park ES, Kim TJ, Shin KS, Wee JJ, Park JD, Yun YP (2006) Antiplatelet and antithrombotic activities of Korean Red Ginseng. Arch Pharm Res 29: 898-903.