Quantification of α- And β-amyrin in rat plasma by gas chromatography-mass spectrometry: Application to preclinical pharmacokinetic study

Journal of Mass Spectrometry

Volumn 46, Issue 5, 2011, Pages 457-464

  Ching, Jianhong ^a   Lin, Hai Shu ^a   Tan, Chay Hoon ^b   Koh, Hwee Ling ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

amyrin; amyrin; absolute oral bioavailability; GC MS; pharmacokinetics

Indexed keywords

ABSOLUTE ORAL BIOAVAILABILITY; BIOLOGICAL ACTIVITIES; CALIBRATION CURVES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GC-MS; LIMIT OF QUANTIFICATIONS; NATURALLY OCCURRING; PHARMACOKINETIC PROFILES; PHARMACOKINETIC STUDIES; PURE COMPOUNDS; RAT PLASMA; RELATIVE STANDARD DEVIATIONS; SPRAGUE-DAWLEY RATS; TRITERPENES;

BIOCHEMISTRY; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); RATS;

PLANT EXTRACTS;

ALPHA AMYRIN; BETA AMYRIN; PLANT EXTRACT; TRITERPENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MASS FRAGMENTOGRAPHY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; INJECTIONS, INTRAVENOUS; LINEAR MODELS; MALE; OLEANOLIC ACID; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

RATTUS;

EID: 79954529440     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1912     Document Type: Article

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