Inhibition of HUVEC tubulogenesis by hederacolchiside-A1 is associated with plasma membrane cholesterol sequestration and activation of the Ha-Ras/MEK/ERK cascade

Cancer Chemotherapy and Pharmacology

Volumn 54, Issue 5, 2004, Pages 432-440

  Barthomeuf, Chantal ^a   Boivin, Dominique ^b   Béliveau, Richard ^b  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Angiogenesis; Cancer; Cholesterol; ERK; Hederacolchiside A1; Ras; Triterpene saponin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CHOLESTEROL; DAMMARANE DERIVATIVE; GINSENOSIDE; HEDERACOLCHISIDE A1; MATRIGEL; MITOGEN ACTIVATED PROTEIN KINASE; OLEANOLIC ACID; SAPONIN; TRITERPENOID; TRITIUM; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MELANOMA CELL; ONCOGENE H RAS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 7744246657     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0813-2     Document Type: Article

References (32)

1. Folkman J (1989) What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82:4-6
2. Gasparini G (1997) Antiangiogenic drugs as a novel anticancer therapeutic strategy. Which are the most promising agents? What are the clinical developments and indications. Crit Rev Oncol Hematol 26:147-162
3. Jain RK (2001) Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 7:987-989
4. Sato K, Mochizuki M, Saiki I, Yoo YC, Samukawa K, Azuma I (1994) Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol Pharm Bull 17:635-639
5. Kitagawa I, Kobayashi M, Akedo H, Tatsuta M, Iishi H, Shinkai K, Mukai M, Imamura F (1995) Inhibition of tumor cell invasion and metastasis by ginsenoside Rg-3. Ginseng Rev 20:41-46
6. Mochizuki M, Yoo YC, Matsuzawa K, Sato K, Saiki I, Tonooka S, Samukawa K, Azuma I (1995) Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol Pharm Bull 18:1197-1202
7. Nakata H, Kikuchi Y, Tode T, Hirata J, Kita T, Ishii K, Kudoh K, Nagata I, Shinomiya N (1998) Inhibitory effects of ginsenoside Rh-2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res 89:733-740
8. Shinkai K, Akedo H, Mukai M, Imamura F, Isoai A, Kobayashi M, Kitagawa I (1996) Inhibition of in vitro tumor cell invasion by ginsenoside Rg3. Jpn J Cancer Res 87:357-362
9. Ministry of Health (2000) Rg-3 shenyi Jiaonang, Health News. Chinese Ministry of Health, Beijing, May 2000
10. Yun TK (2003) Experimental and epidemiological evidence on non-organ specific cancer preventive effect of Korean ginseng and identification of active compounds. Mutat Res 523-524:63-74
11. Setzer WN, Setzer MC (2003) Plant-derived triterpenoids as potential antineoplastic agents. Mini Rev Med Chem 3:540-556
12. Barthomeuf C, Debiton E, Mshvildadze V, Kemertelidze E, Balansard G (2002) In vitro activity of Hederacolchisid A1 as compared with other saponins from Hedera colchica, on human carcinoma and melanoma cells. Planta Med 68:672-675
13. Debiton E, Borel M, Communal Y, Mshvildadze V, Barthomeuf C (2004) In addition to membrane injury, an affinity for melananin might be involved in the high sensitivity of human melanoma cells to hederacolchicoside A1. Melanoma Res 14:97-105
14. Hall HI, Miller DR, Rogers JD, Bewerse B (1999) Update on the incidence and mortality from melanoma in the United States. J Am Acad Dermatol 40:35-42
15. Hostettmann K, Marston A (1995) Chemistry and pharmacology of natural products: saponins. Cambridge University, Cambridge
16. Melzig MF, Bader G, Loose R (2001) Investigations on the mechanism of membrane activity of selected triterpenoid saponins. Planta Med 67:43-48
17. Anderson RG (1998) The caveolae membrane system. Annu Rev Biochem 67:199-225
18. Kabouridis PS, Janzen J, Magee AL, Ley SC (2000) Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signalling pathways in T lymphocytes. Eur J Immunol 30:954-963
19. Park H, Go YM, St John PL, Maland MC, Lisanti MP, Abrahamson DR, Jo H (1998) Plasma membrane cholesterol is a key molecule in shear stress-dependent activation of extracellular signal-regulated kinase. J Biol Chem 273:32304-32311
20. Mshvildadze VD, Elias R, Faure R, Debrauwer L, Dekanosidze GE, Kemertelidze E, Balansard G (2001) Triterpenoid saponins from berries of Hedera colchica. Chem Pharm Bull 49:52-54
21. Corvera S, DiBonaventura C, Shpetner HS (2000) Cell confluence-dependent remodeling of endothelial membranes mediated by cholesterol. J Biol Chem 275:31414-31421
22. Klein U, Gimpl G, Fahrenholz F (1995) Alteration of the myometrial plasma membrane cholesterol content with beta-cyclodextrin modulates the binding affinity of the oxytocin receptor. Biochemistry 34:13784-13793
23. Baatout S, Cheta N (1996) Matrigel: a useful tool to study endothelial differentiation and apoptosis induction. Rom J Intern Med 34:263-269
24. Lamy S, Gingras D, Beliveau R (2002) Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation. Cancer Res 62:381-385
25. Furuchi T, Anderson RG (1998) Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK). J Biol Chem 273:21099-21104
26. Popovich DG, Kitts DD (2002) Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch Biochem Biophys 406:1-8
27. Wang PY, Liu P, Weng J, Sontag E, Anderson RGW (2003) A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity. EMBO J 22:2658-2667
28. Halfon MS, Carmena A, Gisselbrecht S (2000) Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell 103:63-74
29. Cuda G, Paternò R, Ceravolo R, Candigliota M, Perroti N, Perticone F, Faniello MC, Schepis F, Ruocco A, Mele E, Cassano S, Bifulco M, Santillo M, Avvedimento E (2002) Protection of human endothelial cells from oxidative stress. Role of Ras-ERK1/2 signaling. Circulation 105:968-978
30. Haridas V, Higuchi M, Jayatilake GS, Bailey D, Mujoo K, Blake ME, Arntzen CJ, Gutterman JU (2001) Avicins: triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Med Sci 98:5821-5826
31. Labrecque L, Royal I, Surprenant DS, Patterson C, Gingras D, Beliveau R (2003) Regulation of vascular endothelial growth factor receptor-2 activity by caveolin-1 and plasma membrane cholesterol. Mol Biol Cell 14:334-347
32. Suleyman H, Mshvildadze V, Gepdiremen A, Elias R (2003) Acute and chronic antiinflammatory profile of the ivy plant, Hedera helix, in rats. Phytomedicine 10:370-374