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Volumn 2, Issue APR, 2012, Pages

ROR1 and ROR2 in human malignancies: Potentials for targeted therapy

Author keywords

Immunotherapy; Receptor tyrosine kinase orphan receptors (ROR1 ROR2); Solid tumor; Wnt beta catenin

Indexed keywords

DASATINIB; MONOCLONAL ANTIBODY; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; RITUXIMAB;

EID: 84869065974     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2012.00034     Document Type: Review
Times cited : (68)

References (63)
  • 1
    • 0038385028 scopus 로고    scopus 로고
    • One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B
    • Afzal, A. R., and Jeffery, S. (2003). One gene, two phenotypes: ROR2 mutations in autosomal recessive Robinow syndrome and autosomal dominant brachydactyly type B. Hum. Mutat. 22, 1-11.
    • (2003) Hum. Mutat. , vol.22 , pp. 1-11
    • Afzal, A.R.1    Jeffery, S.2
  • 3
    • 0034838873 scopus 로고    scopus 로고
    • Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development
    • Al-Shawi, R., Ashton, S. V., Underwood, C., and Simons, J. P. (2001). Expression of the Ror1 and Ror2 receptor tyrosine kinase genes during mouse development. Dev. Genes Evol. 211, 161-171.
    • (2001) Dev. Genes Evol. , vol.211 , pp. 161-171
    • Al-Shawi, R.1    Ashton, S.V.2    Underwood, C.3    Simons, J.P.4
  • 9
    • 14644427141 scopus 로고    scopus 로고
    • Low expression of Wnt-5a gene is associated with high-risk neuroblastoma
    • Blanc, E., Roux, G. L., Benard, J., and Raguenez, G. (2005). Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. Oncogene 24, 1277-1283.
    • (2005) Oncogene , vol.24 , pp. 1277-1283
    • Blanc, E.1    Roux, G.L.2    Benard, J.3    Raguenez, G.4
  • 10
    • 0033527066 scopus 로고    scopus 로고
    • An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation
    • Bowden, E. T., Barth, M., Thomas, D., Glazer, R. I., and Mueller, S. C. (1999). An invasion-related complex of cortactin, paxillin and PKCmu associates with invadopodia at sites of extracellular matrix degradation. Oncogene 18, 4440-4449.
    • (1999) Oncogene , vol.18 , pp. 4440-4449
    • Bowden, E.T.1    Barth, M.2    Thomas, D.3    Glazer, R.I.4    Mueller, S.C.5
  • 18
    • 0033607015 scopus 로고    scopus 로고
    • A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division
    • Forrester, W. C., Dell, M., Perens, E., and Garriga, G. (1999). A C. elegans Ror receptor tyrosine kinase regulates cell motility and asymmetric cell division. Nature 400, 881-885.
    • (1999) Nature , vol.400 , pp. 881-885
    • Forrester, W.C.1    Dell, M.2    Perens, E.3    Garriga, G.4
  • 20
    • 79954622199 scopus 로고    scopus 로고
    • Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis
    • Gentile, A., Lazzari, L., Benvenuti, S., Trusolino, L., and Comoglio, P. M. (2011). Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res. 71, 3132-3141.
    • (2011) Cancer Res. , vol.71 , pp. 3132-3141
    • Gentile, A.1    Lazzari, L.2    Benvenuti, S.3    Trusolino, L.4    Comoglio, P.M.5
  • 21
    • 37248999443 scopus 로고    scopus 로고
    • The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway
    • Green, J. L., Inoue, T., and Sternberg, P. W. (2007). The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development 134, 4053-4062.
    • (2007) Development , vol.134 , pp. 4053-4062
    • Green, J.L.1    Inoue, T.2    Sternberg, P.W.3
  • 22
    • 54249099446 scopus 로고    scopus 로고
    • Ror receptor tyrosine kinases: orphans no more
    • Green, J. L., Kuntz, S. G., and Sternberg, P. W. (2008). Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol. 18, 536-544.
    • (2008) Trends Cell Biol. , vol.18 , pp. 536-544
    • Green, J.L.1    Kuntz, S.G.2    Sternberg, P.W.3
  • 26
    • 27744528481 scopus 로고    scopus 로고
    • Comparative genomics on ROR1 and ROR2 orthologs
    • Katoh, M. (2005). Comparative genomics on ROR1 and ROR2 orthologs. Oncol. Rep. 14, 1381-1384.
    • (2005) Oncol. Rep. , vol.14 , pp. 1381-1384
    • Katoh, M.1
  • 29
    • 32944464205 scopus 로고    scopus 로고
    • Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis
    • Kurban, G., Hudon, V., Duplan, E., Ohh, M., and Pause, A. (2006). Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Res. 66, 1313-1319.
    • (2006) Cancer Res. , vol.66 , pp. 1313-1319
    • Kurban, G.1    Hudon, V.2    Duplan, E.3    Ohh, M.4    Pause, A.5
  • 30
    • 77955639050 scopus 로고    scopus 로고
    • Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells
    • doi:10.1371/journal.pone.0011859
    • Li, P., Harris, D., Liu, Z., Liu, J., Keating, M., and Estrov, Z. (2010). Stat3 activates the receptor tyrosine kinase like orphan receptor-1 gene in chronic lymphocytic leukemia cells. PLoS ONE 5, e11859. doi:10.1371/journal.pone.0011859
    • (2010) PLoS ONE , vol.5
    • Li, P.1    Harris, D.2    Liu, Z.3    Liu, J.4    Keating, M.5    Estrov, Z.6
  • 31
    • 54249096215 scopus 로고    scopus 로고
    • Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase
    • Liu, Y., Rubin, B., Bodine, P. V., and Billiard, J. (2008). Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. J. Cell. Biochem. 105, 497-502.
    • (2008) J. Cell. Biochem. , vol.105 , pp. 497-502
    • Liu, Y.1    Rubin, B.2    Bodine, P.V.3    Billiard, J.4
  • 32
    • 77954975558 scopus 로고    scopus 로고
    • Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded
    • Lyashenko, N., Weissenböck, M., Sharir, A., Erben, R. G., Minami, Y., and Hartmann, C. (2010). Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded. Dev. Dyn. 239, 2266-2277.
    • (2010) Dev. Dyn. , vol.239 , pp. 2266-2277
    • Lyashenko, N.1    Weissenböck, M.2    Sharir, A.3    Erben, R.G.4    Minami, Y.5    Hartmann, C.6
  • 34
    • 0027074850 scopus 로고
    • A novel family of cell surface receptors with tyrosine kinase-like domain
    • Masiakowski, P., and Carroll, R. D. (1992). A novel family of cell surface receptors with tyrosine kinase-like domain. J. Biol. Chem. 267, 26181-26190.
    • (1992) J. Biol. Chem. , vol.267 , pp. 26181-26190
    • Masiakowski, P.1    Carroll, R.D.2
  • 35
    • 67650594771 scopus 로고    scopus 로고
    • The opposing roles of Wnt-5a in cancer
    • McDonald, S. L., and Silver, A. (2009). The opposing roles of Wnt-5a in cancer. Br. J. Cancer 101, 209-214.
    • (2009) Br. J. Cancer , vol.101 , pp. 209-214
    • McDonald, S.L.1    Silver, A.2
  • 36
    • 71049147900 scopus 로고    scopus 로고
    • Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling
    • Mikels, A., Minami, Y., and Nusse, R. (2009). Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J. Biol. Chem. 284, 30167-30176.
    • (2009) J. Biol. Chem. , vol.284 , pp. 30167-30176
    • Mikels, A.1    Minami, Y.2    Nusse, R.3
  • 37
    • 33646241997 scopus 로고    scopus 로고
    • Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context
    • doi:10.1371/journal.pbio.0040115
    • Mikels, A. J., and Nusse, R. (2006). Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4, e115. doi:10.1371/journal.pbio.0040115
    • (2006) PLoS Biol. , vol.4
    • Mikels, A.J.1    Nusse, R.2
  • 38
    • 73949156925 scopus 로고    scopus 로고
    • Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases
    • Minami, Y., Oishi, I., Endo, M., and Nishita, M. (2010). Ror-family receptor tyrosine kinases in noncanonical Wnt signaling: their implications in developmental morphogenesis and human diseases. Dev. Dyn. 239, 1-15.
    • (2010) Dev. Dyn. , vol.239 , pp. 1-15
    • Minami, Y.1    Oishi, I.2    Endo, M.3    Nishita, M.4
  • 40
    • 54249099723 scopus 로고    scopus 로고
    • Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A
    • Nomachi, A., Nishita, M., Inaba, D., Enomoto, M., Hamasaki, M., and Minami, Y. (2008). Receptor tyrosine kinase Ror2 mediates Wnt5a-induced polarized cell migration by activating c-Jun N-terminal kinase via actin-binding protein filamin A. J. Biol. Chem. 283, 27973-27981.
    • (2008) J. Biol. Chem. , vol.283 , pp. 27973-27981
    • Nomachi, A.1    Nishita, M.2    Inaba, D.3    Enomoto, M.4    Hamasaki, M.5    Minami, Y.6
  • 44
    • 6544275956 scopus 로고    scopus 로고
    • Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system
    • Oishi, I., Takeuchi, S., Hashimoto, R., Nagabukuro, A., Ueda, T., Liu, Z. J., Hatta, T., Akira, S., Matsuda, Y., Yamamura, H., Otani, H., and Minami, Y. (1999). Spatio-temporally regulated expression of receptor tyrosine kinases, mRor1, mRor2, during mouse development: implications in development and function of the nervous system. Genes Cells 4, 41-56.
    • (1999) Genes Cells , vol.4 , pp. 41-56
    • Oishi, I.1    Takeuchi, S.2    Hashimoto, R.3    Nagabukuro, A.4    Ueda, T.5    Liu, Z.J.6    Hatta, T.7    Akira, S.8    Matsuda, Y.9    Yamamura, H.10    Otani, H.11    Minami, Y.12
  • 46
    • 0031569868 scopus 로고    scopus 로고
    • Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis
    • Reddy, U. R., Phatak, S., Allen, C., Nycum, L. M., Sulman, E. P., White, P. S., and Biegel, J. A. (1997). Localization of the human Ror1 gene (NTRKR1) to chromosome 1p31-p32 by fluorescence in situ hybridization and somatic cell hybrid analysis. Genomics 41, 283-285.
    • (1997) Genomics , vol.41 , pp. 283-285
    • Reddy, U.R.1    Phatak, S.2    Allen, C.3    Nycum, L.M.4    Sulman, E.P.5    White, P.S.6    Biegel, J.A.7
  • 47
    • 0029845111 scopus 로고    scopus 로고
    • Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains
    • Reddy, U. R., Phatak, S., and Pleasure, D. (1996). Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. Oncogene 13, 1555-1559.
    • (1996) Oncogene , vol.13 , pp. 1555-1559
    • Reddy, U.R.1    Phatak, S.2    Pleasure, D.3
  • 48
    • 0031739964 scopus 로고    scopus 로고
    • The frizzled motif: in how many different protein families does it occur?
    • Rehn, M., Pihlajaniemi, T., Hofmann, K., and Bucher, P. (1998). The frizzled motif: in how many different protein families does it occur? Trends Biochem. Sci. 23, 415-417.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 415-417
    • Rehn, M.1    Pihlajaniemi, T.2    Hofmann, K.3    Bucher, P.4
  • 49
    • 0022977712 scopus 로고
    • A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps
    • Sadowski, I., Stone, J. C., and Pawson, T. (1986). A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Mol. Cell. Biol. 6, 4396-4408.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 4396-4408
    • Sadowski, I.1    Stone, J.C.2    Pawson, T.3
  • 50
    • 75649084593 scopus 로고    scopus 로고
    • Wnt5a regulates distinct signalling pathways by binding to Frizzled2
    • Sato, A., Yamamoto, H., Sakane, H., Koyama, H., and Kikuchi, A. (2010). Wnt5a regulates distinct signalling pathways by binding to Frizzled2. EMBO J. 29, 41-54.
    • (2010) EMBO J. , vol.29 , pp. 41-54
    • Sato, A.1    Yamamoto, H.2    Sakane, H.3    Koyama, H.4    Kikuchi, A.5
  • 53
    • 84855944650 scopus 로고    scopus 로고
    • Retargeting NK92 cells using an HLA-A2-restricted EBNA3C-specific chimeric antigen receptor
    • Tassev, D. V., Cheng, M., and Cheung, N. K. (2012). Retargeting NK92 cells using an HLA-A2-restricted EBNA3C-specific chimeric antigen receptor. Cancer Gene Ther. 19, 84-100.
    • (2012) Cancer Gene Ther. , vol.19 , pp. 84-100
    • Tassev, D.V.1    Cheng, M.2    Cheung, N.K.3
  • 54
    • 80052102768 scopus 로고    scopus 로고
    • Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL)
    • Uhrmacher, S., Schmidt, C., Erdfelder, F., Poll-Wolbeck, S. J., Gehrke, I., Hallek, M., and Kreuzer, K. A. (2011). Use of the receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a diagnostic tool in chronic lymphocytic leukemia (CLL). Leuk. Res. 35, 1360-1366.
    • (2011) Leuk. Res. , vol.35 , pp. 1360-1366
    • Uhrmacher, S.1    Schmidt, C.2    Erdfelder, F.3    Poll-Wolbeck, S.J.4    Gehrke, I.5    Hallek, M.6    Kreuzer, K.A.7
  • 56
    • 0034773599 scopus 로고    scopus 로고
    • SH2 and SH3 domains as targets for anti-proliferative agents
    • Vidal, M., Gigoux, V., and Garbay, C. (2001). SH2 and SH3 domains as targets for anti-proliferative agents. Crit. Rev. Oncol. Hematol. 40, 175-186.
    • (2001) Crit. Rev. Oncol. Hematol. , vol.40 , pp. 175-186
    • Vidal, M.1    Gigoux, V.2    Garbay, C.3
  • 57
    • 33748979745 scopus 로고    scopus 로고
    • Invadopodia: specialized cell structures for cancer invasion
    • Weaver, A. M. (2006). Invadopodia: specialized cell structures for cancer invasion. Clin. Exp. Metastasis 23, 97-105.
    • (2006) Clin. Exp. Metastasis , vol.23 , pp. 97-105
    • Weaver, A.M.1
  • 58
    • 0027205387 scopus 로고
    • Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases
    • Wilson, C., Goberdhan, D. C., and Steller, H. (1993). Dror, a potential neurotrophic receptor gene, encodes a Drosophila homolog of the vertebrate Ror family of Trk-related receptor tyrosine kinases. Proc. Natl. Acad. Sci. U.S.A. 90, 7109-7113.
    • (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 7109-7113
    • Wilson, C.1    Goberdhan, D.C.2    Steller, H.3
  • 60
    • 35748986142 scopus 로고    scopus 로고
    • Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2
    • Yamamoto, H., Yoo, S. K., Nishita, M., Kikuchi, A., and Minami, Y. (2007). Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12, 1215-1223.
    • (2007) Genes Cells , vol.12 , pp. 1215-1223
    • Yamamoto, H.1    Yoo, S.K.2    Nishita, M.3    Kikuchi, A.4    Minami, Y.5
  • 61
    • 79958776633 scopus 로고    scopus 로고
    • Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies
    • doi:10.1371/journal.pone.0021018
    • Yang, J., Baskar, S., Kwong, K. Y., Kennedy, M. G., Wiestner, A., and Rader, C. (2011). Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies. PLoS ONE 6, e21018. doi:10.1371/journal.pone.0021018
    • (2011) PLoS ONE , vol.6
    • Yang, J.1    Baskar, S.2    Kwong, K.Y.3    Kennedy, M.G.4    Wiestner, A.5    Rader, C.6
  • 62
    • 0037237125 scopus 로고    scopus 로고
    • Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans
    • Yoda, A., Oishi, I., and Minami, Y. (2003). Expression and function of the Ror-family receptor tyrosine kinases during development: lessons from genetic analyses of nematodes, mice, and humans. J. Recept. Signal Transduct. Res. 23, 1-15.
    • (2003) J. Recept. Signal Transduct. Res. , vol.23 , pp. 1-15
    • Yoda, A.1    Oishi, I.2    Minami, Y.3
  • 63
    • 84863251015 scopus 로고    scopus 로고
    • ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth
    • doi:10.1371/journal.pone.0031127
    • Zhang, S., Chen, L., Cui, B., Chuang, H. Y., Yu, J., Wang-Rodriguez, J., Tang, L., Chen, G., Basak, G. W., and Kipps, T. J. (2012). ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS ONE 7, e31127. doi:10.1371/journal.pone.0031127
    • (2012) PLoS ONE , vol.7
    • Zhang, S.1    Chen, L.2    Cui, B.3    Chuang, H.Y.4    Yu, J.5    Wang-Rodriguez, J.6    Tang, L.7    Chen, G.8    Basak, G.W.9    Kipps, T.J.10


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