Predictors of clinical outcome in a national hospitalised cohort across both waves of the influenza A/H1N1 pandemic 2009-2010 in the UK

Thorax

Volumn 67, Issue 8, 2012, Pages 709-717

  Myles, Puja R ^a   Semple, Malcolm G ^b   Lim, Wei Shen ^c   Openshaw, Peter J M ^d   Gadd, Elaine M ^e   Read, Robert C ^f   Taylor, Bruce L ^g   Brett, Stephen J ^h   McMenamin, James ⁱ   Enstone, Joanne E ^a   Armstrong, Colin ^e   Bannister, Barbara ^e   Nicholson, Karl G ^j   Nguyen Van Tam, Jonathan S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^e Skipton House ^*  (United Kingdom)

^f UNIVERSITY OF SHEFFIELD   (United Kingdom)

^g PORTSMOUTH HOSPITALS NHS TRUST   (United Kingdom)

^h IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

ⁱ HEALTH PROTECTION SCOTLAND   (United Kingdom)

^j LEICESTER ROYAL INFIRMARY   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIVIRUS AGENT; C REACTIVE PROTEIN; OXYGEN;

2009 H1N1 INFLUENZA; ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CHILD; CHRONIC LUNG DISEASE; COHORT ANALYSIS; COMORBIDITY; DEMOGRAPHY; DISEASE SEVERITY; ETHNIC DIFFERENCE; FEMALE; FLUID RESUSCITATION; HEALTH CARE POLICY; HIGH RISK POPULATION; HOSPITALIZATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUROLOGIC DISEASE; NEWBORN; OBESITY; OUTCOME ASSESSMENT; OXYGEN THERAPY; PANDEMIC; PATIENT CARE; PNEUMONIA; PRESCHOOL CHILD; PRESCRIPTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RESPIRATORY TRACT INFECTION; SCHOOL CHILD; SEASONAL VARIATION; UNITED KINGDOM; WINTER;

EID: 84864014039     PISSN: 00406376     EISSN: 14683296     Source Type: Journal    
DOI: 10.1136/thoraxjnl-2011-200266     Document Type: Article

References (29)

1. Peres-Padila R, de la Rosa-Zamboni D, Ponce de Leon S, et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 2009;361:680-9.
2. Dawood FS, Jain S, Finelli L, et al; Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;360:2605-15.
3. Nguyen-Van-Tam J, Openshaw P, Hashim A, et al. Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (MayeSeptember 2009). Thorax 2010;65:645-51.
4. Jackson LV, Thalange NK, Cole TJ, et al. Blood pressure centiles for Great Britain. Arch Dis Child 2007;92:298-303. (Pubitemid 46535509)
5. Charlson M, Pompei P, Ales K, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987;40:373-83. (Pubitemid 17055592)
6. Deyo R, Cherkin D, Ciol M, et al. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992;45:613-19.
7. McLean E, Pebody R. Epidemiological Report of Pandemic (H1N1) 2009 in the UK: April 2009 - May 2010. London: Health Protection Agency, 2010. http://www.hpa. org.uk/Publications/InfectiousDiseases/Influenza/ 1010EpidemiologicalreportofpandemicH1N12009inUK/ (accessed 18 Mar 2011).
8. Chalmers JD, Singanayagam A, Hill AT. C-reactive protein is an independent predictor of severity in community-acquired pneumonia. Am J Med 2008;121:219-25. (Pubitemid 351317927)
9. Cals JW, Schot MJ, de Jong SA, et al. Point-of-care C-reactive protein testing and antibiotic prescribing for respiratory tract infections: a randomized controlled trial. Ann Fam Med 2010;8:124-33.
10. Launch of National Pandemic Flu Service. London: Department of Health, 2009. http://www.dh.gov.uk/en/Publicationsandstatistics/Lettersandcirculars/DH- 103226 (accessed 18 Mar 2011).
11. Yu H, Feng Z, Uyeki T, et al. Risk factors for severe illness with 2009 pandemic influenza A(H1N1) virus infection in China. Clin Infect Dis 2011;52:457-65.
12. Taubenberger JK, Morens DM. 1918 influenza: the mother of all pandemics. Emerg Infect Dis 2006;12:15-22. (Pubitemid 43143529)
13. Kumar A, Zarychanski R, Pinto R, et al. Critically ill patients with 2009 influenza A (H1N1) infection in Canada. JAMA 2009;302:1872-9.
14. van Gageldonk-Lafeber AB, van der Sande MA, Meiher A, et al. A case-control study on influenza A (H1N1) 2009 infection in the first few 100 cases and close contacts: results and lessons learned from the Netherlands. Poster A316P. 4th European Scientific Working Group on Influenza (ESWI) Conference. Malta, 2011.
15. Xu R, Ekiert DC, Krause JC, et al. Structural basis of pre-existing immunity to the 2009 H1N1 pandemic influenza virus. Science 2010;328:357-60.
16. Monsalvo AC, Batalle JP, Lopez MF, et al. Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes. Nat Med 2011;17:195-9.
17. Jain S, Kamimoto L, Bramley A, et al. Hospitalised patients with 2009 H1N1 influenza in the United States, AprileJune 2009. N Engl J Med 2009;361:1935-44.
18. Tutuncu EE, Ozturk B, Gurbuz Y, et al. Clinical characteristics of 74 pandemic H1N1 influenza patients from Turkey. Risk factors for fatality. Saudi Med J 2010;31:993-8.
19. Jaber S, Conseil M, Coisel Y, et al. ARDS and influenza A (H1N1): patients characteristics and management in intensive care unit. A literature review. Ann Fr Anesth Reanim 2010;29:117-25.
20. Subramony H, Lai FY, Ang LW, et al. An epidemiological study of 1348 cases of pandemic H1N1 influenza admitted to Singapore hospitals from July to September 2009. Annal Acad Med Singapore 2010;39:283-90.
21. Martin-Loeches I, Rodriguez A, Bonastre J, et al. Severe pandemic (H1N1)v influenza A infection: report on the first deaths in Spain. Respirology 2010;16:78-85.
22. Shieh W, Blau DM, Denison AM, et al. 2009 pandemic influenza A (H1N1): pathology and pathogenesis of 100 fatal cases in the United States. Am J Pathol 2010;177:166-75.
23. Louie JK, Acosta M, Winter K, et al. Factors associated with death or hospitalisation due to pandemic 2009 influenza A (H1N1) infection in California. JAMA 2009;302:1896-902.
24. Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Immunol 2006;6:772-83. (Pubitemid 44453463)
25. Kapiotis S, Holzer G, Schaller G, et al. A proinflammatory state is detectable in obese children and is accompanied by functional and morphological vascular changes. Arterioscler Thromb Vasc Biol 2006;26:2541.
26. Sachedina N, Donaldson LJ. Paediatric mortality related to influenza A H1N1 infection in England: an observational population-based study. Lancet 2010;376:1846-52.
27. Zimmerman O, Rogowski O, Aviram G, et al. C-reactive protein serum levels as an early predictor of outcome in patients with pandemic H1N1 influenza A virus infection. BMC Infect Dis 2010;10:288.
28. Presanis AM, Pebody RG, Paterson BJ, et al. Changes in severity of 2009 pandemic A/H1N1 influenza in England: a Bayesian evidence synthesis. BMJ. 2011;343:d5408.
29. Singanayagam A, Singanayagam A, Wood V, et al. Factors associated with severe illness in pandemic 2009 influenza a (H1N1) infection: implications for triage in primary and secondary care. J Infect 2011;63:243-51.