Development of a profiling strategy for metabolic mixtures by combining chromatography and mass spectrometry with cell-based gpcr signaling

Journal of Biomolecular Screening

Volumn 17, Issue 10, 2012, Pages 1329-1338

  Nijmeijer, Saskia ^a   Vischer, Henry F ^a   Rudebeck, Anders F ^a   Fleurbaaij, Frank ^a   Falck, David ^a   Leurs, Rob ^a   Niessen, Wilfried M A ^a   Kool, Jeroen ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

GPCR; high resolution fractionation; histamine H4 receptor; in line screening; ligand metabolites; miniaturization; signal transduction

Indexed keywords

BETA GALACTOSIDASE; CLOZAPINE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; HISTAMINE H4 RECEPTOR;

ARTICLE; CELL STRUCTURE; CELL VIABILITY; CLINICAL EVALUATION; FRACTIONATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TIME OF FLIGHT MASS SPECTROMETRY; VALIDATION PROCESS;

CELL LINE; CHROMATOGRAPHY, LIQUID; CYCLIC AMP; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MASS SPECTROMETRY; METABOLOME; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HISTAMINE; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION;

EID: 84869023823     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112451922     Document Type: Article

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