Histamine contributes to increased RANKL to osteoprotegerin ratio through altered nuclear receptor 4A activity in human chondrocytes

Arthritis and Rheumatism

Volumn 64, Issue 10, 2012, Pages 3290-3301

  Marzaioli, Viviana ^a   McMorrow, Jason P ^a   Angerer, Hannes ^b   Gilmore, Alyssa ^a   Crean, Daniel ^a   Zocco, Davide ^a   Rooney, Peadar ^c   Veale, Douglas ^c   Fearon, Ursula ^c   Gogarty, Martina ^a   McEvoy, Alice N ^d   Stradner, Martin H ^b   Murphy, Evelyn P ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

^c ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^d DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H4 RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR RECEPTOR 4A1; NUCLEAR RECEPTOR 4A2; NUCLEAR RECEPTOR 4A3; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROTEOGLYCAN; SHORT HAIRPIN RNA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE CELL; CARTILAGE DEGENERATION; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN SECRETION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEADY STATE; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

CARTILAGE, ARTICULAR; CELL LINE; CELLS, CULTURED; CHONDROCYTES; HISTAMINE; HISTAMINE ANTAGONISTS; HUMANS; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 1; OSTEOPROTEGERIN; RANK LIGAND; RECEPTORS, HISTAMINE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84869002560     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34554     Document Type: Article

References (49)

1. Nigrovic PA, Lee DM. Synovial mast cells: role in acute and chronic arthritis. Immunol Rev 2007; 217: 19-37. (Pubitemid 46718141)
2. Xu D, Jiang HR, Kewin P, Li Y, Mu R, Fraser AR, et al. IL-33 exacerbates antigen-induced arthritis by activating mast cells. Proc Natl Acad Sci U S A 2008; 105: 10913-8.
3. Tebib J, Mariette X, Bourgeois P, Flipo RM, Gaudin P, Le Loet X, et al. Masitinib in the treatment of active rheumatoid arthritis: results of a multicentre, open-label, dose-ranging, phase 2a study. Arthritis Res Ther 2009;11:R95.
4. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol 2010; 6: 625-35.
5. Nakano S, Mishiro T, Takahara S, Yokoi H, Hamada D, Yukata K, et al. Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis. Clin Rheumatol 2007; 26: 1284-92. (Pubitemid 47034184)
6. Grzybowska-Kowalczyk A, Wojtecka-Lukasik E, Maslinska D, Gujski M, Maslinski S. Distribution pattern of histamine H4 receptor in human synovial tissue from patients with rheumatoid arthritis. Inflamm Res 2007;56 Suppl 1:S59-60. (Pubitemid 47345701)
7. Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, et al. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol 2006;7: 284-92.
8. Adlesic M, Verdrengh M, Bokarewa M, Dahlberg L, Foster SJ, Tarkowski A. Histamine in rheumatoid arthritis. Scand J Immunol 2007; 65: 530-7. (Pubitemid 46808855)
9. Biosse-Duplan M, Baroukh B, Dy M, de Vernejoul MC, Saffar JL. Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts. Am J Pathol 2009; 174: 1426-34.
10. Yamaura K, Yonekawa T, Nakamura T, Yano S, Ueno K. The histamine H2-receptor antagonist, cimetidine, inhibits the articular osteopenia in rats with adjuvant-induced arthritis by suppressing the osteoclast differentiation induced by histamine. J Pharmacol Sci 2003; 92: 43-9. (Pubitemid 36712171)
11. Fitzpatrick LA, Buzas E, Gagne TJ, Nagy A, Horvath C, Ferencz V, et al. Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomyinduced bone loss. Proc Natl Acad Sci U S A 2003; 100: 6027-32. (Pubitemid 36576925)
12. Tetlow LC, Woolley DE. Histamine stimulates the proliferation of human articular chondrocytes in vitro and is expressed by chondrocytes in osteoarthritic cartilage. Ann Rheum Dis 2003;62: 991-4. (Pubitemid 37159499)
13. Tetlow LC, Woolley DE. Effect of histamine on the production of matrix metalloproteinases-1, -3, -8 and -13, and TNF-and PGE2 by human articular chondrocytes and synovial fibroblasts in vitro: a comparative study. Virchows Arch 2004; 445: 485-90. (Pubitemid 39592752)
14. Zocco D, McMorrow JP, Murphy EP. Histamine modulation of peripheral CRH receptor type 1-expression is dependent on Ca2-signalling and NF-B/p65 transcriptional activity. Mol Immunol 2010; 47: 1426-37.
15. Mix KS, Attur MG, Al-Mussawir H, Abramson SB, Brinckerhoff CE, Murphy EP. Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage. J Biol Chem 2007; 282: 9492-504. (Pubitemid 47104569)
16. Murphy EP, McEvoy A, Conneely OM, Bresnihan B, FitzGerald O. Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin- releasing hormone expression and actions in human inflammatory arthritis. Arthritis Rheum 2001;44: 782-93. (Pubitemid 32319770)
17. Hamers AA, Vos M, Rassam F, Marincovic G, Kurakula K, van Gorp PJ, et al. Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis. Circ Res 2012; 110: 428-38.
18. Sekiya T, Kashiwagi I, Inoue N, Morita R, Hori S, Waldmann H, et al. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4-T cells. Nat Commun 2011; 2: 269.
19. Lippert U, Artuc M, Grutzkau A, Babina M, Guhl S, Haase I, et al. Human skin mast cells express H2 and H4, but not H3 receptors. J Investig Dermatol 2004; 123: 116-23. (Pubitemid 38833472)
20. Shahriar M, Mizuguchi H, Maeyama K, Kitamura Y, Orimoto N, Horio S, et al. Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions. J Immunol 2009; 183: 2133-41.
21. Osawa H, Kita H, Ohnishi H, Mutoh H, Ishino Y, Satoh K, et al. Histamine-2 receptor expression in gastric mucosa before and after Helicobacter pylori cure. Aliment Pharmacol Ther 2005;21: 92-8. (Pubitemid 40806588)
22. Sugata Y, Okano M, Fujiwara T, Matsumoto R, Hattori H, Yamamoto M, et al. Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology 2007; 121: 266-75. (Pubitemid 46663095)
23. Luo XH, Guo LJ, Xie H, Yuan LQ, Wu XP, Zhou HD, et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway. J Bone Miner Res 2006; 21: 1648-56. (Pubitemid 44484610)
24. Ralph JA, Zocco D, Bresnihan B, FitzGerald O, McEvoy AN, Murphy EP. A role for type 1-corticotropin-releasing hormone receptors in mediating local changes in chronically inflamed tissue. Am J Pathol 2007; 170: 1121-33. (Pubitemid 47339378)
25. McEvoy AN, Murphy EA, Ponnio T, Conneely OM, Bresnihan B, FitzGerald O, et al. Activation of nuclear orphan receptor NURR1 transcription by NF-B and cyclic adenosine 5-monophosphate response element-binding protein in rheumatoid arthritis synovial tissue. J Immunol 2002; 168: 2979-87.
26. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, et al. Identification of a novel inhibitor of mitogenactivated protein kinase kinase. J Biol Chem 1998; 273: 18623-32. (Pubitemid 28334795)
27. Cummins EP, Berra E, Comerford KM, Ginouves A, Fitzgerald KT, Seeballuck F, et al. Prolyl hydroxylase-1 negatively regulates I-B kinase-, giving insight into hypoxia-induced NF-B activity. Proc Natl Acad Sci U S A 2006; 103: 18154-9.
28. Komuro H, Olee T, Kuhn K, Quach J, Brinson DC, Shikhman A, et al. The osteoprotegerin/receptor activator of nuclear factor -B/receptor activator of nuclear factor -B ligand system in cartilage. Arthritis Rheum 2001; 44: 2768-76. (Pubitemid 34016196)
29. Hofbauer LC, Lacey DL, Dunstan CR, Spelsberg TC, Riggs BL, Khosla S. Interleukin-1-and tumor necrosis factor-, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells. Bone 1999; 25: 255-9.
30. Zhang YH, Heulsmann A, Tondravi MM, Mukherjee A, Abu- Amer Y. Tumor necrosis factor-(TNF) stimulates RANKLinduced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem 2001; 276: 563-8. (Pubitemid 32050352)
31. Ota N, Takaishi H, Kosaki N, Takito J, Yoda M, Tohmonda T, et al. Accelerated cartilage resorption by chondroclasts during bone fracture healing in osteoprotegerin-deficient mice. Endocrinology 2009; 150: 4823-34.
32. Kwan Tat S, Amiable N, Pelletier JP, Boileau C, Lajeunesse D, Duval N, et al. Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis. Rheumatology (Oxford) 2009; 48: 1482-90.
33. Saidenberg-Kermanac'h N, Cohen-Solal M, Bessis N, De Vernejoul MC, Boissier MC. Role for osteoprotegerin in rheumatoid inflammation. Joint Bone Spine 2004; 71: 9-13. (Pubitemid 38183280)
34. Adamopoulos I, Danks L, Itonaga I, Locklin R, Sabokbar A, Ferguson D, et al. Stimulation of osteoclast formation by inflammatory synovial fluid. Virchows Arch 2006; 449: 69-77. (Pubitemid 43988367)
35. Ziolkowska M, Kurowska M, Radzikowska A, Luszczykiewicz G, Wiland P, Dziewczopolski W, et al. High levels of osteoprotegerin and soluble receptor activator of nuclear factor -B ligand in serum of rheumatoid arthritis patients and their normalization after anti-tumor necrosis factor - treatment. Arthritis Rheum 2002;46: 1744-53. (Pubitemid 34774505)
36. Upton AR, Holding CA, Dharmapatni AS, Haynes DR. The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatol Int 2012; 32: 535-40.
37. Shimizu S, Asou Y, Itoh S, Chung UI, Kawaguchi H, Shinomiya K, et al. Prevention of cartilage destruction with interarticular osteo-clastogenesis inhibitory factor/osteoprotegerin in a murine model of arthritis. Arthritis Rheum 2007; 56: 3358-65. (Pubitemid 47585430)
38. Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS, Murphy EP. Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol 2009; 46: 3345-57.
39. Jutel M, Watanabe T, Klunker S, Akdis M, Thomet OA, Malolepszy J, et al. Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors. Nature 2001; 413:420-5. (Pubitemid 32928596)
40. Van Der Pouw Kraan TC, Snijders A, Boeije LC, de Groot ER, Alewijnse AE, Leurs R, et al. Histamine inhibits the production of interleukin-12 through interaction with H2 receptors. J Clin Invest 1998; 102: 1866-73. (Pubitemid 28533834)
41. Yang XD, Ai W, Asfaha S, Bhagat G, Friedman RA, Jin G, et al. Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b-Ly6G-immature myeloid cells. Nat Med 2011; 17: 87-95.
42. Hanna RN, Shaked I, Hubbeling HG, Punt JA, Wu R, Herrley E, et al. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res 2012; 110: 416-27.
43. Pirih FQ, Nervina JM, Pham L, Aghaloo T, Tetradis S. Parathyroid hormone induces the nuclear orphan receptor NOR-1 in osteoblasts. Biochem Biophys Res Commun 2003; 306: 144-50. (Pubitemid 36629418)
44. Lammi J, Aarnisalo P. FGF-8 stimulates the expression of NR4A orphan nuclear receptors in osteoblasts. Mol Cell Endocrinol 2008; 295: 87-93.
45. Lammi J, Huppunen J, Aarnisalo P. Regulation of the osteopontin gene by the orphan nuclear receptor NURR1 in osteoblasts. Mol Endocrinol 2004; 18: 1546-57. (Pubitemid 38696932)
46. Pirih FQ, Tang A, Ozkurt IC, Nervina JM, Tetradis S. Nuclear orphan receptor NURR1 directly transactivates the osteocalcin gene in osteoblasts. J Biol Chem 2004; 279: 53167-74. (Pubitemid 40051819)
47. Reinholt FP, Hultenby K, Oldberg A, Heineard D. Osteopontin - a possible anchor of osteoclasts to bone. Proc Natl Acad Sci U S A 1990; 87: 4473-5.
48. Rajasekaran N, Solomon S, Watanabe T, Ohtsu H, Gajda M, Brauer R, et al. Histidine decarboxylase but not histamine receptor 1 or 2 deficiency protects from K/BxN serum-induced arthritis. Int Immunol 2009; 21: 1263-8.
49. Lundquist A, Calonova G, Wensman H, Roonberg E, Pejiler G. Differential modulation of NR4A subfamily of nuclear receptor following mast cell activation. Mol Immunol 2011; 48: 1753-6.