Lentiviral Transduction of CD34+ Cells Induces Genome-Wide Epigenetic Modifications

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Yamagata, Yoshiaki ^a,b   Parietti, Véronique ^a   Stockholm, Daniel ^a   Corre, Guillaume ^a   Poinsignon, Catherine ^a,c   Touleimat, Nizar ^d   Delafoy, Damien ^d   Besse, Céline ^d   Tost, Jörg ^d,e   Galy, Anne ^a,c   Paldi, András ^a  

^a GÉNÉTHON   (France)

^b YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^d CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^e FONDATION JEAN DAUSSET CEPH   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; DNA METHYLTRANSFERASE 1; SIRTUIN 1; VIRUS DNA; VIRUS PROTEIN; VIRUS VECTOR;

ARTICLE; CD34+ T LYMPHOCYTE; CELL ACTIVITY; CELL CULTURE; CELL POPULATION; CELL STIMULATION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA MODIFICATION; EPIGENETICS; EX VIVO GENE TRANSFER; EX VIVO STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LENTIVIRINAE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRAL GENE DELIVERY SYSTEM; VIRUS GENOME;

ANTIGENS, CD34; CELLS, CULTURED; CYTOKINES; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; EPIGENESIS, GENETIC; EPIGENOMICS; FETAL BLOOD; GENETIC THERAPY; GENETIC VECTORS; GENOME; HEMATOPOIETIC STEM CELLS; HUMANS; LENTIVIRUS; SIRTUIN 1; TRANSDUCTION, GENETIC;

EID: 84868692069     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048943     Document Type: Article

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