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Volumn 77, Issue 1, 2010, Pages 64-75

High content image cytometry in the context of subnuclear organization

Author keywords

H2AX; Actinomycin D; Data mining; DNA damage; High content screening; Image cytometry; Nucleus; Phenotype; Transfection

Indexed keywords

CELL NUCLEUS; CELLS, CULTURED; DACTINOMYCIN; DNA DAMAGE; FIBROBLASTS; FLOW CYTOMETRY; HUMANS; IMAGE CYTOMETRY; IMMUNOHISTOCHEMISTRY; RADIATION, IONIZING; ULTRAVIOLET RAYS;

EID: 74049110106     PISSN: 15524922     EISSN: 15524930     Source Type: Journal    
DOI: 10.1002/cyto.a.20807     Document Type: Article
Times cited : (64)

References (67)
  • 2
    • 2942596411 scopus 로고    scopus 로고
    • Cytomics - new technologies: Towards a human cytome project
    • Valet G, Leary JF, Tarnok A. Cytomics - new technologies: Towards a human cytome project. Cytometry A 2004;59A:167-171.
    • (2004) Cytometry A , vol.59 A , pp. 167-171
    • Valet, G.1    Leary, J.F.2    Tarnok, A.3
  • 3
    • 33845760114 scopus 로고    scopus 로고
    • Automated subcellular location determination and high-throughput microscopy
    • Glory E, Murphy RF. Automated subcellular location determination and high-throughput microscopy. Dev Cell 2007;12:7-16.
    • (2007) Dev Cell , vol.12 , pp. 7-16
    • Glory, E.1    Murphy, R.F.2
  • 5
    • 33745948356 scopus 로고    scopus 로고
    • Automated interpretation of subcellular patterns in fluorescence microscope images for location proteomics
    • Chen X, Velliste M, Murphy RF. Automated interpretation of subcellular patterns in fluorescence microscope images for location proteomics. Cytometry A 2006;69A: 631-640.
    • (2006) Cytometry A , vol.69 A , pp. 631-640
    • Chen, X.1    Velliste, M.2    Murphy, R.F.3
  • 7
    • 65549144451 scopus 로고    scopus 로고
    • Single-cellbased image analysis of high-throughput cell array screens for quantification of viral infection
    • Matula P, Kumar A, Worz I, Erfle H, Bartenschlager R, Eils R, Rohr K. Single-cellbased image analysis of high-throughput cell array screens for quantification of viral infection. Cytometry A 2009;75A:309-318.
    • (2009) Cytometry A , vol.75 A , pp. 309-318
    • Matula, P.1    Kumar, A.2    Worz, I.3    Erfle, H.4    Bartenschlager, R.5    Eils, R.6    Rohr, K.7
  • 8
    • 65649141657 scopus 로고    scopus 로고
    • Digital titration: Automated image acquisition and analysis of load and growth of Chlamydophila psittaci
    • Beeckman DS, Meesen G, Van Oostveldt P, Vanrompay D. Digital titration: Automated image acquisition and analysis of load and growth of Chlamydophila psittaci. Microsc Res Tech 2009;72:398-402.
    • (2009) Microsc Res Tech , vol.72 , pp. 398-402
    • Beeckman, D.S.1    Meesen, G.2    Van Oostveldt, P.3    Vanrompay, D.4
  • 9
    • 34250882643 scopus 로고    scopus 로고
    • Quantitative morphological signatures define local signaling networks regulating cell morphology
    • Bakal C, Aach J, Church G, Perrimon N. Quantitative morphological signatures define local signaling networks regulating cell morphology. Science 2007;316:1753-1756.
    • (2007) Science , vol.316 , pp. 1753-1756
    • Bakal, C.1    Aach, J.2    Church, G.3    Perrimon, N.4
  • 10
    • 46049088308 scopus 로고    scopus 로고
    • Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model
    • Chen Y, Wei T, Yan L, Lawrence F, Qian HR, Burkholder TP, Starling JJ, Yingling JM, Shou J. Developing and applying a gene functional association network for anti-angiogenic kinase inhibitor activity assessment in an angiogenesis co-culture model. BMC Genomics 2008;9:264.
    • (2008) BMC Genomics , vol.9 , pp. 264
    • Chen, Y.1    Wei, T.2    Yan, L.3    Lawrence, F.4    Qian, H.R.5    Burkholder, T.P.6    Starling, J.J.7    Yingling, J.M.8    Shou, J.9
  • 13
    • 34250216344 scopus 로고    scopus 로고
    • Image-based multivariate profiling of drug responses from single cells
    • Loo LH, Wu LF, Altschuler SJ. Image-based multivariate profiling of drug responses from single cells. Nat Methods 2007;4:445-453.
    • (2007) Nat Methods , vol.4 , pp. 445-453
    • Loo, L.H.1    Wu, L.F.2    Altschuler, S.J.3
  • 14
    • 67650070045 scopus 로고    scopus 로고
    • Multi-parameter phenotypic profiling: Using cellular effects to characterize small-molecule compounds
    • Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: Using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov 2009;8:567-578.
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 567-578
    • Feng, Y.1    Mitchison, T.J.2    Bender, A.3    Young, D.W.4    Tallarico, J.A.5
  • 17
    • 73449105776 scopus 로고    scopus 로고
    • The dynamic landscape of the cell nucleus
    • in press
    • Austin CM, Bellini M. The dynamic landscape of the cell nucleus. Mol Reprod Dev (in press).
    • Mol Reprod Dev
    • Austin, C.M.1    Bellini, M.2
  • 18
    • 18744375181 scopus 로고    scopus 로고
    • Concepts in nuclear architecture
    • Misteli T. Concepts in nuclear architecture. Bioessays 2005;27:477-487.
    • (2005) Bioessays , vol.27 , pp. 477-487
    • Misteli, T.1
  • 22
    • 62549094378 scopus 로고    scopus 로고
    • The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells
    • Knecht H, Sawan B, Lichtensztejn D, Lemieux B, Wellinger RJ, Mai S. The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells. Leukemia 2009;23:565-573.
    • (2009) Leukemia , vol.23 , pp. 565-573
    • Knecht, H.1    Sawan, B.2    Lichtensztejn, D.3    Lemieux, B.4    Wellinger, R.J.5    Mai, S.6
  • 25
    • 17844396282 scopus 로고    scopus 로고
    • Simultaneous in situ profiling of DNA lesion endpoints based on image cytometry and a single cell database approach
    • Baert P, Meesen G, De Schynkel S, Poffijn A, Van Oostveldt P. Simultaneous in situ profiling of DNA lesion endpoints based on image cytometry and a single cell database approach. Micron 2005;36:321-330.
    • (2005) Micron , vol.36 , pp. 321-330
    • Baert, P.1    Meesen, G.2    De Schynkel, S.3    Poffijn, A.4    Van Oostveldt, P.5
  • 26
    • 3042547731 scopus 로고    scopus 로고
    • Combining intensity, edge and shape information for 2D and 3D segmentation of cell nuclei in tissue sections
    • Wahlby C, Sintorn IM, Erlandsson F, Borgefors G, Bengtsson E. Combining intensity, edge and shape information for 2D and 3D segmentation of cell nuclei in tissue sections. J Microsc 2004;215:67-76.
    • (2004) J Microsc , vol.215 , pp. 67-76
    • Wahlby, C.1    Sintorn, I.M.2    Erlandsson, F.3    Borgefors, G.4    Bengtsson, E.5
  • 27
    • 0028134135 scopus 로고
    • Automatic detection of clustered, fluorescent-stained nuclei by digital image-based cytometry
    • Lockett SJ, Herman B. Automatic detection of clustered, fluorescent-stained nuclei by digital image-based cytometry. Cytometry 1994;17:1-12.
    • (1994) Cytometry , vol.17 , pp. 1-12
    • Lockett, S.J.1    Herman, B.2
  • 28
    • 74049158816 scopus 로고    scopus 로고
    • Available at
    • Rasband W. Image J 1997-2009, Available at http://rsb.info.nih.gov/ij/.
    • (1997)
    • Rasband, W.1    Image, J.2
  • 33
    • 25444502873 scopus 로고    scopus 로고
    • Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation
    • Desai N, Davis E, O'Neill P, Durante M, Cucinotta FA, Wu H. Immunofluorescence detection of clustered gamma-H2AX foci induced by HZE-particle radiation. Radiat Res 2005;164:518-522.
    • (2005) Radiat Res , vol.164 , pp. 518-522
    • Desai, N.1    Davis, E.2    O'Neill, P.3    Durante, M.4    Cucinotta, F.A.5    Wu, H.6
  • 35
    • 25444490915 scopus 로고    scopus 로고
    • Induction and repair of DNA double-strand breaks in human cells: Dephosphorylation of histone H2AX and its inhibition by calyculin A
    • Antonelli F, Belli M, Cuttone G, Dini V, Esposito G, Simone G, Sorrentino E, Tabocchini MA. Induction and repair of DNA double-strand breaks in human cells: Dephosphorylation of histone H2AX and its inhibition by calyculin A. Radiat Res 2005;164:514-517.
    • (2005) Radiat Res , vol.164 , pp. 514-517
    • Antonelli, F.1    Belli, M.2    Cuttone, G.3    Dini, V.4    Esposito, G.5    Simone, G.6    Sorrentino, E.7    Tabocchini, M.A.8
  • 36
    • 29644443047 scopus 로고    scopus 로고
    • Computational Methods for analysis of foci: Validation for radiation-induced gamma-H2AX foci in human cells
    • Bocker W, Iliakis G. Computational Methods for analysis of foci: Validation for radiation-induced gamma-H2AX foci in human cells. Radiat Res 2006;165:113-124.
    • (2006) Radiat Res , vol.165 , pp. 113-124
    • Bocker, W.1    Iliakis, G.2
  • 37
    • 30944457170 scopus 로고    scopus 로고
    • Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells
    • Wadsworth P, Rusan NM, Tulu US, Fagerstrom C. Stable expression of fluorescently tagged proteins for studies of mitosis in mammalian cells. NatMethods 2005;2:981-987.
    • (2005) NatMethods , vol.2 , pp. 981-987
    • Wadsworth, P.1    Rusan, N.M.2    Tulu, U.S.3    Fagerstrom, C.4
  • 38
    • 0032489012 scopus 로고    scopus 로고
    • TRF2 protects human telomeres from end-to-end fusions
    • van Steensel B, Smogorzewska A, de Lange T. TRF2 protects human telomeres from end-to-end fusions. Cell 1998;92:401-413.
    • (1998) Cell , vol.92 , pp. 401-413
    • van Steensel, B.1    Smogorzewska, A.2    de Lange, T.3
  • 39
    • 13244256957 scopus 로고    scopus 로고
    • Hierarchical, model-based merging of multiple fragments for improved three-dimensional segmentation of nuclei
    • Lin G, Chawla MK, Olson K, Guzowski JF, Barnes CA, Roysam B. Hierarchical, model-based merging of multiple fragments for improved three-dimensional segmentation of nuclei. Cytometry A 2005;63A:20-33.
    • (2005) Cytometry A , vol.63 A , pp. 20-33
    • Lin, G.1    Chawla, M.K.2    Olson, K.3    Guzowski, J.F.4    Barnes, C.A.5    Roysam, B.6
  • 41
    • 37549005552 scopus 로고    scopus 로고
    • High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles
    • Li F, Zhou X, Zhu J, Ma J, Huang X, Wong ST. High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles. BMC Biotechnol 2007;7:66.
    • (2007) BMC Biotechnol , vol.7 , pp. 66
    • Li, F.1    Zhou, X.2    Zhu, J.3    Ma, J.4    Huang, X.5    Wong, S.T.6
  • 42
    • 58249098812 scopus 로고    scopus 로고
    • Analysis and recognition of touching cell images based on morphological structures
    • Yu D, Pham TD, Zhou X. Analysis and recognition of touching cell images based on morphological structures. Comput Biol Med 2009;39:27-39.
    • (2009) Comput Biol Med , vol.39 , pp. 27-39
    • Yu, D.1    Pham, T.D.2    Zhou, X.3
  • 44
    • 65349140037 scopus 로고    scopus 로고
    • A tool for enhancement and scoring of DNA repair foci
    • Gerashchenko BI, Dynlacht JR. A tool for enhancement and scoring of DNA repair foci. Cytometry A 2009;75A:245-252.
    • (2009) Cytometry A , vol.75 A , pp. 245-252
    • Gerashchenko, B.I.1    Dynlacht, J.R.2
  • 45
  • 46
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 2000;10:886-895.
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 47
    • 0004820949 scopus 로고
    • Actinomycin and DNA transcription
    • Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci USA 1985;82: 5328-5331.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 5328-5331
    • Sobell, H.M.1
  • 48
    • 15744362987 scopus 로고    scopus 로고
    • Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II
    • Mischo HE, Hemmerich P, Grosse F, Zhang S. Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. J Biol Chem 2005;280:9586-9594.
    • (2005) J Biol Chem , vol.280 , pp. 9586-9594
    • Mischo, H.E.1    Hemmerich, P.2    Grosse, F.3    Zhang, S.4
  • 49
    • 0034183276 scopus 로고    scopus 로고
    • Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells
    • Kleeff J, Kornmann M, Sawhney H, Korc M. Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells. Int J Cancer 2000;86:399-407.
    • (2000) Int J Cancer , vol.86 , pp. 399-407
    • Kleeff, J.1    Kornmann, M.2    Sawhney, H.3    Korc, M.4
  • 50
    • 0017119344 scopus 로고
    • Effects of actinomycin D on cell cycle kinetics and the DNA of Chinese hamster and mouse mammary tumor cells cultivated in vitro
    • Roots R, Smith KC. Effects of actinomycin D on cell cycle kinetics and the DNA of Chinese hamster and mouse mammary tumor cells cultivated in vitro. Cancer Res 1976;36:3654-3658.
    • (1976) Cancer Res , vol.36 , pp. 3654-3658
    • Roots, R.1    Smith, K.C.2
  • 51
    • 0029079228 scopus 로고
    • Apoptosis in antitumor strategies: Modulation of cell cycle or differentiation
    • Darzynkiewicz Z. Apoptosis in antitumor strategies: Modulation of cell cycle or differentiation. J Cell Biochem 1995;58:151-159.
    • (1995) J Cell Biochem , vol.58 , pp. 151-159
    • Darzynkiewicz, Z.1
  • 52
    • 0036158769 scopus 로고    scopus 로고
    • Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes
    • Gomez-Lechon MJ, O'Connor E, Castell JV, Jover R. Sensitive markers used to identify compounds that trigger apoptosis in cultured hepatocytes. Toxicol Sci 2002;65: 299-308.
    • (2002) Toxicol Sci , vol.65 , pp. 299-308
    • Gomez-Lechon, M.J.1    O'Connor, E.2    Castell, J.V.3    Jover, R.4
  • 53
    • 56549107036 scopus 로고    scopus 로고
    • Bromodeoxyuridine photodamage in studies of UVA damage and the cell cycle
    • Snapka RM. Bromodeoxyuridine photodamage in studies of UVA damage and the cell cycle. DNA Repair (Amst) 2009;8:3.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 3
    • Snapka, R.M.1
  • 54
    • 0015788532 scopus 로고
    • The lesions produced by ultraviolet light in DNA containing 5-bromouracil
    • Hutchinson F. The lesions produced by ultraviolet light in DNA containing 5-bromouracil. Q Rev Biophys 1973;6:201-246.
    • (1973) Q Rev Biophys , vol.6 , pp. 201-246
    • Hutchinson, F.1
  • 55
    • 33745607326 scopus 로고    scopus 로고
    • H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks
    • Marti TM, Hefner E, Feeney L, Natale V, Cleaver JE. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc Natl Acad Sci USA 2006;103:9891-9896.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9891-9896
    • Marti, T.M.1    Hefner, E.2    Feeney, L.3    Natale, V.4    Cleaver, J.E.5
  • 56
    • 33644545366 scopus 로고    scopus 로고
    • Quantitative analysis reveals asynchronous and more than DSB-associated histone H2AX phosphorylation after exposure to ionizing radiation
    • Han J, Hendzel MJ, Lalunis-Turner J. Quantitative analysis reveals asynchronous and more than DSB-associated histone H2AX phosphorylation after exposure to ionizing radiation. Radiat Res 2006;165:283-292.
    • (2006) Radiat Res , vol.165 , pp. 283-292
    • Han, J.1    Hendzel, M.J.2    Lalunis-Turner, J.3
  • 58
    • 0034437901 scopus 로고    scopus 로고
    • Complexity of damage produced by ionizing radiation
    • Ward JF. Complexity of damage produced by ionizing radiation. Cold Spring Harb Symp Quant Biol 2000;65:377-382.
    • (2000) Cold Spring Harb Symp Quant Biol , vol.65 , pp. 377-382
    • Ward, J.F.1
  • 60
    • 53549123008 scopus 로고    scopus 로고
    • Raj A, Van OA. Nature, nurture, or chance: Stochastic gene expression and its consequences. Cell 2008;135:216-226.
    • Raj A, Van OA. Nature, nurture, or chance: Stochastic gene expression and its consequences. Cell 2008;135:216-226.
  • 62
    • 35848964790 scopus 로고    scopus 로고
    • Breast tumor heterogeneity: Cancer stem cells or clonal evolution?
    • Campbell LL, Polyak K. Breast tumor heterogeneity: Cancer stem cells or clonal evolution?. Cell Cycle 2007;6:2332-2338.
    • (2007) Cell Cycle , vol.6 , pp. 2332-2338
    • Campbell, L.L.1    Polyak, K.2
  • 63
    • 48449098623 scopus 로고    scopus 로고
    • Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
    • Gascoigne KE, Taylor SS. Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 2008;14:111-122.
    • (2008) Cancer Cell , vol.14 , pp. 111-122
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 64
    • 26844550896 scopus 로고    scopus 로고
    • Accelerated discovery of novel protein function in cultured human cells
    • Hodges E, Redelius JS, Wu W, Hoog C. Accelerated discovery of novel protein function in cultured human cells. Mol Cell Proteomics 2005;4:1319-1327.
    • (2005) Mol Cell Proteomics , vol.4 , pp. 1319-1327
    • Hodges, E.1    Redelius, J.S.2    Wu, W.3    Hoog, C.4
  • 66
    • 13844300843 scopus 로고    scopus 로고
    • From quantitative microscopy to automated image understanding
    • Huang K, Murphy RF. From quantitative microscopy to automated image understanding. J Biomed Opt 2004;9:893-912.
    • (2004) J Biomed Opt , vol.9 , pp. 893-912
    • Huang, K.1    Murphy, R.F.2


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