Role of glycosphingolipids in the function of human serotonin1A receptors

Journal of Neurochemistry

Volumn 123, Issue 5, 2012, Pages 716-724

  Singh, Pushpendra ^a   Paila, Yamuna Devi ^a   Chattopadhyay, Amitabha ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

G protein coupled receptor; glucosylceramide synthase; glycosphingolipids; PDMP; SBD; serotonin1A receptors

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE; GLYCOSPHINGOLIPID; GUANINE NUCLEOTIDE BINDING PROTEIN; SEROTONIN 1A RECEPTOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL VIABILITY; CHO CELL; CONTROLLED STUDY; ENZYME INHIBITION; FEMALE; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR BINDING;

ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; GLYCOSPHINGOLIPIDS; HUMANS; RECEPTOR, SEROTONIN, 5-HT1A;

EUKARYOTA;

EID: 84868659218     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12008     Document Type: Article

References (72)

1. Alemany R., Perona J. S., Sánchez-Dominguez J. M., Montero E., Cañizares J., Bressani R., Escribá P. V., and, Ruiz-Guitierrez V., (2007) G protein-coupled receptor systems and their lipid environment in health disorders during aging. Biochim. Biophys. Acta 1768, 964-975.
2. Amundson D. M., and, Zhou M., (1999) Fluorometric method for the enzymatic determination of cholesterol. J. Biochem. Biophys. Methods 38, 43-52.
3. Ariga T., McDonald M. P., and, Yu R. K., (2008) Role of ganglioside metabolism in the pathogenesis of Alzheimer's diseaseâa review. J. Lipid Res. 49, 1157-1175.
4. Baier C. J., and, Barrantes F. J., (2007) Sphingolipids are necessary for nicotinic acetylcholine receptor export in the early secretory pathway. J. Neurochem. 101, 1072-1084.
5. Bektas M., and, Spiegel S., (2004) Glycosphingolipids and cell death. Glycoconj. J. 20, 39-47.
6. 1A agonists in the treatment of depression? Biol. Psychiatry 53, 193-203.
7. Brown R. E., (1998) Sphingolipid organization in biomembranes: what physical studies of model membranes reveal. J. Cell Sci. 111, 1-9.
8. Chakrabandhu K., Huault S., Garmy N., Fantini J., Stebe E., Mailfert S., Marguet D., and, Hueber A.-O., (2008) The extracellular glycosphingolipid- binding motif of Fas defines its internalization route, mode and outcome of signals upon activation by ligand. Cell Death Differ. 15, 1824-1837.
9. 1A receptor. Adv. Exp. Med. Biol. 749, 279-293.
10. 2- adrenergic G protein-coupled receptor. Science 318, 1258-1265.
11. Contreras F.-X., Ernst A. M., Haberkant P., et al,. (2012) Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature 481, 525-529.
12. Deupi X., and, Kobilka B. K., (2010) Energy landscapes as a tool to integrate GPCR structure, dynamics, and function. Physiology 25, 293-303.
13. Epand R. M., (2006) Cholesterol and the interaction of proteins with membrane domains. Prog. Lipid Res. 45, 279-294.
14. Fantini J., (2003) How sphingolipids bind and shape proteins: molecular basis of lipid-protein interactions in lipid shells, rafts and related biomembrane domains. Cell. Mol. Life Sci. 60, 1027-1032.
15. Fantini J., and, Barrantes F. J., (2009) Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function. Biochim. Biophys. Acta 1788, 2345-2361.
16. Fukasawa M., Nishijima M., Itabe H., Takano T., and, Hanada K., (2000) Reduction of sphingomyelin level without accumulation of ceramide in chinese hamster ovary cells affects detergent-resistant membrane domains and enhances cellular cholesterol efflux to methyl-β-cyclodextrin. J. Biol. Chem. 275, 34028-34034.
17. 1A receptor: a zFCS study. Biophys. J. 99, 1397-1407.
18. Gardier A. M., (2009) Mutant mouse models and antidepressant drug research: focus on serotonin and brain-derived neurotrophic factor. Behav. Pharmacol. 20, 18-32.
19. Gimpl G., Burger K., and, Fahrenholz F., (1997) Cholesterol as modulator of receptor function. Biochemistry 36, 10959-10974.
20. 1A receptor blockers as potential drug candidates for the treatment of anxiety disorders. Drug News Perspect. 12, 484-490.
21. Griffitts J. S., Haslam S. M., Yang T., Garczynski S. F., Mulloy B., Morris H., Cremer P. S., Dell A., Adang M. J., and, Aroian R. V., (2005) Glycolipids as receptors for Bacillus thuringiensis crystal toxin. Science 307, 922-925.
22. 2-adrenergic receptor. Structure 16, 897-905.
23. 1A receptors from bovine hippocampus by an agonist and an antagonist. FEBS Lett. 457, 389-392.
24. Hebbar S., Lee E., Manna M., Steinert S., Kumar G. S., Wenk M., Wohland T., and, Kraut R., (2008) A fluorescent sphingolipid binding domain peptide probe interacts with sphingolipids and cholesterol-dependent raft domains. J. Lipid Res. 49, 1077-1089.
25. Heilker R., Wolff M., Tautermann C. S., and, Bieler M., (2009) G-protein-coupled receptor-focused drug discovery using a target class platform approach. Drug Discov. Today 14, 231-240.
26. Hoekstra D., and, Kok J. W., (1992) Trafficking of glycosphingolipids in eukaryotic cells; sorting and recycling of lipids. Biochim. Biophys. Acta 1113, 277-294.
27. Hug P., Lin H.-M. J., Korte T., Xiao X., Dimitrov D. S., Wang J. M., Puri A., and, Blumenthal R., (2000) Glycosphingolipids promote entry of a broad range of human immunodeficiency virus type 1 isolates into cell lines expressing CD4, CXCR4, and/or CCR5. J. Virol. 74, 6377-6385.
28. Inagaki S., Ghirlando R., White J. F., Gvozdenovic-Jeremic J., Northup J. K., and, Grisshammer R., (2012) Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid. J. Mol. Biol. 417, 95-111.
29. Inokuchi J.-I., and, Radin N. S., (1987) Preparation of the active isomer of l-phenyl-2-decanoylamino-3-morpholino-1-propanol, inhibitor of murine glucocerebroside synthetase. J. Lipid Res. 28, 565-571.
30. Jacobson K., Mouritsen O. G., and, Anderson R. G. W., (2007) Lipid rafts: at a crossroad between cell biology and physics. Nat. Cell Biol. 9, 7-14.
31. Jafurulla M., Tiwari S., and, Chattopadhyay A., (2011) Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors. Biochem. Biophys. Res. Commun. 404, 569-573.
32. Jennemann R., Sandhoff R., Wang S., et al,. (2005) Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth. Proc. Natl Acad. Sci. USA 102, 12459-12464.
33. 1A receptor. Cell. Mol. Neurobiol. 27, 1097-1116.
34. 1A receptor heterologously expressed in CHO cells. Biosci. Rep. 24, 101-115.
35. Lahiri S., and, Futerman A. H., (2007) The metabolism and function of sphingolipids and glycosphingolipids. Cell. Mol. Life Sci. 64, 2270-2284.
36. Lakowicz J. R., (2006) Principles of Fluorescence Spectroscopy, 3rd ed. Springer, New York.
37. Li H., and, Papadopoulos V., (1998) Peripheral-type benzodiazepine receptor function in cholesterol transport. Identification of a putative cholesterol recognition/interaction amino acid sequence and consensus pattern. Endocrinology 139, 4991-4997.
38. 3 interaction. J. Lipid Res. 43, 1670-1679.
39. Mahfoud R., Garmy N., Maresca M., Yahi N., Puigserver A., and, Fantini J., (2002b) Identification of a common sphingolipid-binding domain in Alzheimer, prion, and HIV-1 proteins. J. Biol. Chem. 277, 11292-11296.
40. Makino A., Ishii K., Murate M., et al,. (2006) d -threo-1-Phenyl-2- decanoylamino-3-morpholino-1-propanol alters cellular cholesterol homeostasis by modulating the endosome lipid domains. Biochemistry 45, 4530-4541.
41. Masserini M., and, Ravasi D., (2001) Role of sphingolipids in the biogenesis of membrane domains. Biochim. Biophys. Acta 1532, 149-161.
42. McClare C. W. F., (1971) An accurate and convenient organic phosphorus assay. Anal. Biochem. 39, 527-530.
43. 1A-receptors. Prog. Neurobiol. 81, 133-178.
44. Mutoh T., Tokuda A., Miyadai T., Hamaguchi M., and, Fujiki N., (1995) Ganglioside GM1 binds to the Trk protein and regulates receptor function. Proc. Natl Acad. Sci. USA 92, 5087-5091.
45. Nagafuku M., Kabayama K., Oka D., et al,. (2003) Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor. J. Biol. Chem. 278, 51920-51927.
46. Paila Y. D., and, Chattopadhyay A., (2010) Membrane cholesterol in the function and organization of G-protein coupled receptors. Subcell. Biochem. 51, 439-466.
47. 1A receptor is impaired in cellular model of Smith-Lemli-Opitz Syndrome. Biochim. Biophys. Acta 1778, 1508-1516.
48. 1A receptors. Biochemistry 49, 2389-2397.
49. Pierce K. L., Premont R. T., and, Lefkowitz R. J., (2002) Seven-transmembrane receptors. Nat. Rev. Mol. Cell Biol. 3, 639-650.
50. Platt F. M., Neises G. R., Dwek R. A., and, Butters T. D., (1994) N-Butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J. Biol. Chem. 269, 8362-8365.
51. 1A receptor. Glycoconj. J. 26, 733-738.
52. Prinetti A., Loberto N., Chigorno V., and, Sonnino S., (2009) Glycosphingolipid behaviour in complex membranes. Biochim. Biophys. Acta 1788, 184-193.
53. 1A receptors from bovine hippocampus. Biochim. Biophys. Acta 1663, 188-200.
54. Pucadyil T. J., and, Chattopadhyay A., (2006) Role of cholesterol in the function and organization of G-protein coupled receptors. Prog. Lipid Res. 45, 295-333.
55. Pucadyil T. J., and, Chattopadhyay A., (2007) Cholesterol: a potential therapeutic target in Leishmania infection? Trends Parasitol. 23, 49-53.
56. 1A receptor tagged to yellow fluorescent protein. Biochemistry 43, 15852-15862.
57. 1A receptor: a representative member of the serotonin receptor family. Cell. Mol. Neurobiol. 25, 553-580.
58. 1A receptors to inhibitory G protein α-subunits and lack of coupling to Gsα. Biochemistry 32, 11064-11073.
59. Riethmüller J., Riehle A., Grassmé H., and, Gulbins E., (2006) Membrane rafts in host-pathogen interactions. Biochim. Biophys. Acta 1758, 2139-2147.
60. Rosenbaum D. M., Rasmussen S. G. F., and, Kobilka B. K., (2009) The structure and function of G-protein-coupled receptors. Nature 459, 356-363.
61. Schlyer S., and, Horuk R., (2006) I want a new drug: G-protein-coupled receptors in drug development. Drug Discov. Today 11, 481-493.
62. Shayman J. A., Mahdiyoun S., Deshmukh G., Barcelon F., Inokuchi J.-I., and, Radin N. S., (1990) Glucosphingolipid dependence of hormone-stimulated inositol triphosphate formation. J. Biol. Chem. 265, 12135-12138.
63. 1A receptors. Biochemistry 49, 5426-5435.
64. Simons K., and, van Meer G., (1988) Lipid sorting in epithelial cells. Biochemistry 27, 6197-6202.
65. Simons K., and, Toomre D., (2000) Lipid rafts and signal transduction. Nat. Rev. Mol. Cell Biol. 1, 31-39.
66. 1A receptor: implications in desmosterolosis. Biochim. Biophys. Acta 1788, 2169-2173.
67. Smith P. K., Krohn R. I., Hermanson G. T., Mallia A. K., Gartner F. H., Provenzano M. D., Fujimoto E. K., Goeke N. M., Olson B. J., and, Klenk D. C., (1985) Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
68. Unal H., and, Karnik S. S., (2012) Domain coupling in GPCRs: the engine for induced conformational changes. Trends Pharmacol. Sci. 33, 79-88.
69. Wang X., Rahman Z., Sun P., Meuillet E., George D., Bremer E. G., Al-Qamari A., and, Paller A. S., (2001) Ganglioside modulates ligand binding to the epidermal growth factor receptor. J. Invest. Dermatol. 116, 69-76.
70. Yamashita T., Wada R., Sasaki T., Deng C., Bierfreund U., Sandhoff K., and, Proia R. L., (1999) A vital role for glycosphingolipid synthesis during development and differentiation. Proc. Natl Acad. Sci. USA 96, 9142-9147.
71. Zhang Y., DeVries M. E., and, Skolnick J., (2006) Structure modeling of all identified G protein-coupled receptors in the human genome. PLoS Comput. Biol. 2, 88-99.
72. 1A binding sites. Brain Res. Mol. Brain Res. 69, 186-201.