Antihypertensive effects of DL-tetrahydropalmatine: An active principle isolated from Corydalis

Clinical and Experimental Pharmacology and Physiology

Volumn 23, Issue 8, 1996, Pages 738-745

  Lin, M T ^a   Chueh, F Y ^b   Hsieh, M T ^b   Chen, C F ^c  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Bradycardia; Dopamine; Hypotension; Hypothalamus; Serotonin; Tetrahydropalmatine

Indexed keywords

APOMORPHINE; NORADRENALIN; SEROTONIN; TETRAHYDROPALMATINE;

ANIMAL EXPERIMENT; BRADYCARDIA; CONFERENCE PAPER; HEART FUNCTION; HYPERTENSION; HYPOTENSION; HYPOTHALAMUS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT;

EID: 0029812235     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.1996.tb01769.x     Document Type: Conference Paper

References (20)

1. Dharmananda S. The story of jin bu huan. Herbal Grammalogue 1994;31:28-31.
2. Hsu B, Kin KC. Pharmacological study of tetrahydropalmatine and its analogs. Arch. Int. Pharmacodyn. Ther. 1962; 139:318-27.
3. Hsu B, Kin KC. Further studies on the pharmacology of tetra-hydropalmatine and its analogs. Int. J. Neuropharmacol. 1964; 2: 283-90.
4. Kin KC, Hsu B. Study on the pharmacological actions of Corydalis I. Analgesic action of Cordalis A, B and L. Acta Physiol. Sin. 1957; 21: 150-7.
5. Zhu DY. Recent advances on the active components in Chinese medicine. ACME 1987; 1: 251-86.
6. Wang Y, Li DX. Antiarrhythmic action of 1-tetrahydropalmatine. Acta Pharmacol. Sin. 1987; 8: 337-40.
7. Liu D, Zhao GS. Effects of DL-tetrahydropalmatine on cardiac hemodynamics in dogs. Yao Hsueh Pao 1987; 22: 537-40 (in Chinese).
8. Cornish JL, Van den Buuse M. Presser responses to electrical and chemical stimulation of the rat brain A10 dopaminergic system. Neurosci. Lett. 1994; 176: 142-6.
9. Kühn DM, Wolf WA, Lovenberg W. Review of the role of the antral serotonergic neuronal system in blood pressure regulation. Hypertension 1980; 2: 243-55.
10. Lin MT, Yang JJ. Stimulation of the nigrostriatal dopamine system produces hypertension and tachycardia in rats. Am. J. Physiol. 1994; 226: H2489-96. ;
11. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. Academic Press, New York. 1982.
12. Jin GZ, Kin KC, Xu J, Zhang FT, Yu LP. Relevance of sedative tranquilizing mechanism of 1-tetrahydropalmatine to brain monoaminergic system. Acta Pharmacol. Sinica 1983; 4: 4-10.
13. Jin GZ, Kin KC, Wang XL, Shi WX. Tetrahydroprotoberbcrine. A new chemical type of antagonist of the dopamine receptor. Sci. Sin. 1985; 10: 925-30.
14. Xu SX, Chen Y, Jin GZ. Comparison of affinities of tetrahydroprotoberberine on dopamine receptor in calf caudatum. Kexue Tongbao 1985; 30: 468-71 (in Chinese).
15. Xu SX, XuLP, HanYR, Chen Y, Jin GZ. Effects of terahydroprotoberberine on dopaminergic receptor subtypes in brain. Acta Pharmacol. Sin. 1989; 10: 104-10.
16. Jin GZ, Xu SX, Yu LP. Different effects of L- and D-tetrahydropalmatine on dopaminergic system in rat's brain. Sci. Sin. j 1985; 11: 1015-22. J
17. Minson J, Chalmers J, Droet G et al. Central serotonergic mechanisms in cardiovascular regulation. Cardiovasc. Drugs Ther. 1990; 4: 27-32.
18. Gillis RA, Mandai AK, Hernandez YM, Norman WP, Dretchen j KE, Travagli RA. Brainstem serotonin receptor subtypes and I control. Adv. Biosci. 1992; 85: 361-81.
19. Kristic M, Djiirlpvic D. Analysis of cardiovascular response to .- central administration of 5-hydroxytryptamine in rats. Neuropharmacohgy 1980; 19: 455-63.
20. Mandai AK, Kellar KJ, Norman WP, Gillis RA. Stimulation of serotonin 2 receptors in the ventrolateral medulla of the cat results in nonuniform increases in sympathetic outflow. Circ. Res. 1990; 67: 1267-80.