Stereoselective metabolism of tetrahydropalmatine enantiomers in rat liver microsomes

Chirality

Volumn 24, Issue 5, 2012, Pages 368-373

  Zhao, Ming ^a   Li, Li Ping ^a   Sun, Dong Li ^a   Sun, Si Yuan ^a   Huang, Shan Ding ^b   Zeng, Su ^a   Jiang, Hui Di ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b NINGBO UNIVERSITY   (China)

Author keywords

CYP1A2; CYP3A1 2; liver microsomes; stereoselective metabolism; tetrahydropalmatine

Indexed keywords

BETA NAPHTHOFLAVONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DEXAMETHASONE; FLUVOXAMINE; KETOCONAZOLE; TETRAHYDROPALMATINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG METABOLISM; ENANTIOMER; HAPLORHINI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY;

ANIMALS; BERBERINE ALKALOIDS; BETA-NAPHTHOFLAVONE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES; DEXAMETHASONE; DOGS; FLUVOXAMINE; HAPLORHINI; KETOCONAZOLE; MALE; MEMBRANE PROTEINS; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84860461194     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.22020     Document Type: Article

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