Radiosynthesis of the candidate β-amyloid radioligand [11C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys

Synapse

Volumn 64, Issue 10, 2010, Pages 733-741

  Andersson, Jan D ^a   Varnäss, Katarina ^a   Nyi, Zsolt Csele ^a,b   Gulyás, Balázs ^a   Wensbo, David ^b   Finnema, Sjoerd J ^a   Swahn, Britt Marie ^c   Svensson, Samuel ^c   Nyberg, Svante ^b   Farde, Lars ^a,b   Halldin, Christer ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Alzheimer's disease; Amyloid plaques; Positron emission tomography; Radioligand development; Radiosynthesis

Indexed keywords

[(N METHYL) 2 (6 METHYLAMINO PYRIDIN 3 YL)BENZO[D]THIAZOL] 6 OL C 11; AZD 2184; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOSIMETRY; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

AMINOPYRIDINES; ANIMALS; BENZOTHIAZOLES; BRAIN; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; IMAGING, THREE-DIMENSIONAL; MACACA FASCICULARIS; MASS SPECTROMETRY; POSITRON-EMISSION TOMOGRAPHY; RADIOCHEMISTRY; WHOLE BODY IMAGING;

EID: 77954342079     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20782     Document Type: Article

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