P16INK4a exerts an anti-inflammatory effect through accelerated irak1 degradation in macrophages

Journal of Immunology

Volumn 189, Issue 10, 2012, Pages 5066-5072

  Murakami, Yousuke ^a,b   Mizoguchi, Fumitaka ^a   Saito, Tetsuya ^a   Miyasaka, Nobuyuki ^a   Kohsaka, Hitoshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 ACETYL 8 CYCLOPENTYL 5 METHYL 2 [5 (1 PIPERAZINYL) 2 PYRIDINYLAMINO] 8H PYRIDO[2,3 D]PYRIMIDIN 7 ONE; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL AGING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; FIBROBLAST; GENE TRANSFER; HUMAN; HUMAN CELL; MACROPHAGE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RHEUMATOID SYNOVIAL FIBROBLAST; SENESCENCE; UPREGULATION;

ANIMALS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE MODELS, ANIMAL; FIBROBLASTS; INFLAMMATION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; PROTEOLYSIS; SYNOVIAL MEMBRANE; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITINATION;

EID: 84868589822     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1103156     Document Type: Article

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