Simvastatin attenuates axonal injury after experimental traumatic brain injury and promotes neurite outgrowth of primary cortical neurons

Brain Research

Volumn 1486, Issue , 2012, Pages 121-130

  Wu, Hongtao ^a   Mahmood, Asim ^a   Qu, Changsheng ^a   Xiong, Ye ^a   Chopp, Michael ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Axonal injury; Glycogen synthase kinase 3 ; Neurite outgrowth; Simvastatin; Traumatic brain injury

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AMYLOID PRECURSOR PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; MAMMALIAN TARGET OF RAPAMYCIN; NEUROFILAMENT H; NEUROFILAMENT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; SIMVASTATIN; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AXONAL INJURY; BRAIN CELL; COLON POLYPOSIS; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; MALE; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; SYNAPTOGENESIS; TRAUMATIC BRAIN INJURY; TREATMENT DURATION; WESTERN BLOTTING;

ANIMALS; AXONS; BRAIN INJURIES; CELLS, CULTURED; CEREBRAL CORTEX; MALE; NEURITES; NEURONS; RATS; RATS, WISTAR; SIMVASTATIN;

RATTUS NORVEGICUS;

EID: 84868589660     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.09.039     Document Type: Article

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