Structure and function of an RNase H domain at the heart of the spliceosome

EMBO Journal

Volumn 27, Issue 21, 2008, Pages 2929-2940

  Pena, Vladimir ^a   Rozov, Alexey ^a   Fabrizio, Patrizia ^a   Lührmann, Reinhard ^a   Wahl, Markus C ^a,b  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

pre mRNA splicing; Prp8 protein; RNase H domain; Splicing catalysis; X ray crystallography

Indexed keywords

MESSENGER RNA PRECURSOR; PROTEIN DERIVATIVE; PROTEIN PRP8; RIBONUCLEASE H; SMALL NUCLEAR RNA; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME STRUCTURE; GENE MUTATION; MOLECULAR DYNAMICS; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN STABILITY; RNA SPLICING; SITE DIRECTED MUTAGENESIS; SPLICEOSOME; YEAST;

AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CATALYSIS; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PYRIMIDINES; RIBONUCLEASE H; RNA PRECURSORS; RNA SPLICE SITES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT; SPLICEOSOMES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 55549143970     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.209     Document Type: Article

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