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Volumn 32, Issue 45, 2012, Pages 15849-15858

The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; H RAS PROTEIN; N [[5 [(2 AMINO 3 MERCAPTOPROPYL) AMINO] [1, 1' BIPHENYL] 2 YL] CARBONYL] METHIONINE; QUININE; SACCHARIN; SHORT HAIRPIN RNA; SUCROSE; UNCLASSIFIED DRUG; WATER;

EID: 84868566673     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2846-12.2012     Document Type: Article
Times cited : (33)

References (50)
  • 1
  • 2
    • 2342667021 scopus 로고    scopus 로고
    • Constitutive expression of p21H-ras(Val12) in pyramidal neurons results in reorganization of mouse neocortical afferents
    • CrossRef Medline
    • Alpár A, Gärtner U, Seeger G, Härtig W, Brauer K, Arendt T (2004) Constitutive expression of p21H-ras(Val12) in pyramidal neurons results in reorganization of mouse neocortical afferents. J Neurobiol 60:263-274. CrossRef Medline
    • (2004) J Neurobiol , vol.60 , pp. 263-274
    • Alpár, A.1    Gärtner, U.2    Seeger, G.3    Härtig, W.4    Brauer, K.5    Arendt, T.6
  • 4
    • 79960048732 scopus 로고    scopus 로고
    • Glial cell line-derived neu-rotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: Implications for alcohol reward and seeking
    • CrossRef Medline
    • Barak S, Carnicella S, Yowell QV, Ron D (2011) Glial cell line-derived neu-rotrophic factor reverses alcohol-induced allostasis of the mesolimbic dopaminergic system: implications for alcohol reward and seeking. JNeu-rosci 31:9885-9894. CrossRef Medline
    • (2011) JNeu-rosci , vol.31 , pp. 9885-9894
    • Barak, S.1    Carnicella, S.2    Yowell, Q.V.3    Ron, D.4
  • 5
    • 34249018367 scopus 로고    scopus 로고
    • GEFs and GAPs: Critical elements in the control of small G proteins
    • CrossRef Medline
    • Bos JL, Rehmann H, Wittinghofer A (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129:865-877. CrossRef Medline
    • (2007) Cell , vol.129 , pp. 865-877
    • Bos, J.L.1    Rehmann, H.2    Wittinghofer, A.3
  • 7
    • 58549105969 scopus 로고    scopus 로고
    • Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor
    • CrossRef Medline
    • Carnicella S, Amamoto R, Ron D (2009) Excessive alcohol consumption is blocked by glial cell line-derived neurotrophic factor. Alcohol 43:35-43. CrossRef Medline
    • (2009) Alcohol , vol.43 , pp. 35-43
    • Carnicella, S.1    Amamoto, R.2    Ron, D.3
  • 8
    • 79960055459 scopus 로고    scopus 로고
    • RAS interaction with PI3K: More than just another effector pathway
    • CrossRef Medline
    • Castellano E, Downward J (2011) RAS interaction with PI3K: more than just another effector pathway. Genes Cancer 2:261-274. CrossRef Medline
    • (2011) Genes Cancer , vol.2 , pp. 261-274
    • Castellano, E.1    Downward, J.2
  • 10
    • 78649474147 scopus 로고    scopus 로고
    • Ras history: The saga continues
    • CrossRef Medline
    • Cox AD, Der CJ (2010) Ras history: the saga continues. Small GTPases 1:2-27. CrossRef Medline
    • (2010) Small GTPases , vol.1 , pp. 2-27
    • Cox, A.D.1    Der, C.J.2
  • 14
    • 79960053105 scopus 로고    scopus 로고
    • Regulation of neuronal function by Ras-GRF exchange factors
    • CrossRef Medline
    • Feig LA (2011) Regulation of neuronal function by Ras-GRF exchange factors. Genes Cancer 2:306-319. CrossRef Medline
    • (2011) Genes Cancer , vol.2 , pp. 306-319
    • Feig, L.A.1
  • 15
    • 78651379505 scopus 로고    scopus 로고
    • The RasGrf family of mammalian guanine nucleotide exchange factors
    • Medline
    • Fernández-Medarde A, Santos E (2011) The RasGrf family of mammalian guanine nucleotide exchange factors. Biochim Biophys Acta 1815:170-188. Medline
    • (2011) Biochim Biophys Acta , vol.1815 , pp. 170-188
    • Fernández-Medarde, A.1    Santos, E.2
  • 16
    • 4444249258 scopus 로고    scopus 로고
    • Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice
    • CrossRef Medline
    • Gärtner U, Alpár A, Reimann F, Seeger G, Heumann R, Arendt T (2004) Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice. J Neurosci Res 77:630-641. CrossRef Medline
    • (2004) J Neurosci Res , vol.77 , pp. 630-641
    • Gärtner, U.1    Alpár, A.2    Reimann, F.3    Seeger, G.4    Heumann, R.5    Arendt, T.6
  • 17
    • 4444300234 scopus 로고    scopus 로고
    • The role of mesolimbic dopa-mine in the development and maintenance of ethanol reinforcement
    • CrossRef Medline
    • Gonzales RA, Job MO, Doyon WM (2004) The role of mesolimbic dopa-mine in the development and maintenance of ethanol reinforcement. Pharmacol Ther 103:121-146. CrossRef Medline
    • (2004) Pharmacol Ther , vol.103 , pp. 121-146
    • Gonzales, R.A.1    Job, M.O.2    Doyon, W.M.3
  • 18
    • 75749114797 scopus 로고    scopus 로고
    • mTOR signaling: At the crossroads of plasticity, memory and disease
    • CrossRef Medline
    • Hoeffer CA, Klann E (2010) mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci 33:67-75. CrossRef Medline
    • (2010) Trends Neurosci , vol.33 , pp. 67-75
    • Hoeffer, C.A.1    Klann, E.2
  • 19
    • 33748371601 scopus 로고    scopus 로고
    • Neural mechanisms of addiction: The roleof reward-related learning and memory
    • CrossRef Medline
    • Hyman SE, Malenka RC, Nestler EJ (2006) Neural mechanisms of addiction: the roleof reward-related learning and memory. Annu Rev Neurosci 29:565-598. CrossRef Medline
    • (2006) Annu Rev Neurosci , vol.29 , pp. 565-598
    • Hyman, S.E.1    Malenka, R.C.2    Nestler, E.J.3
  • 20
    • 78650431046 scopus 로고    scopus 로고
    • Con-stitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex
    • CrossRef Medline
    • Kaneko M, Cheetham CE, Lee YS, Silva AJ, Stryker MP, Fox K (2010) Con-stitutively active H-ras accelerates multiple forms of plasticity in developing visual cortex. Proc Natl Acad Sci U S A 107:19026-19031. CrossRef Medline
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 19026-19031
    • Kaneko, M.1    Cheetham, C.E.2    Lee, Y.S.3    Silva, A.J.4    Stryker, M.P.5    Fox, K.6
  • 21
    • 0037442509 scopus 로고    scopus 로고
    • The role of synaptic GTPase-activating protein inneuronal development and synaptic plasticity
    • Medline
    • Kim JH, Lee HK, Takamiya K, Huganir RL (2003) The role of synaptic GTPase-activating protein inneuronal development and synaptic plasticity. J Neurosci 23:1119-1124. Medline
    • (2003) J Neurosci , vol.23 , pp. 1119-1124
    • Kim, J.H.1    Lee, H.K.2    Takamiya, K.3    Huganir, R.L.4
  • 22
    • 0037329682 scopus 로고    scopus 로고
    • Alcoholism: Allostasis and beyond
    • CrossRef Medline
    • Koob GF (2003) Alcoholism: allostasis and beyond. Alcohol Clin Exp Res 27:232-243. CrossRef Medline
    • (2003) Alcohol Clin Exp Res , vol.27 , pp. 232-243
    • Koob, G.F.1
  • 23
    • 72049098472 scopus 로고    scopus 로고
    • Neurocircuitry of addiction
    • CrossRef Medline
    • Koob GF, Volkow ND (2010) Neurocircuitry of addiction. Neuropsychop-harmacology 35:217-238. CrossRef Medline
    • (2010) Neuropsychop-harmacology , vol.35 , pp. 217-238
    • Koob, G.F.1    Volkow, N.D.2
  • 25
    • 35748931731 scopus 로고    scopus 로고
    • Downregula-tion of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice
    • CrossRef Medline
    • Lasek AW, Janak PH, He L, Whistler JL, Heberlein U (2007) Downregula-tion of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. Genes Brain Behav 6:728-735. CrossRef Medline
    • (2007) Genes Brain Behav , vol.6 , pp. 728-735
    • Lasek, A.W.1    Janak, P.H.2    He, L.3    Whistler, J.L.4    Heberlein, U.5
  • 26
    • 0023098381 scopus 로고
    • Differential expression of the ras gene family in mice
    • Medline
    • Leon J, Guerrero I, Pellicer A (1987) Differential expression of the ras gene family in mice. Mol Cell Biol 7:1535-1540. Medline
    • (1987) Mol Cell Biol , vol.7 , pp. 1535-1540
    • Leon, J.1    Guerrero, I.2    Pellicer, A.3
  • 27
    • 0346056792 scopus 로고    scopus 로고
    • Recent advances in the neurobiology of alcoholism: The role of adenosine
    • CrossRef Medline
    • Mailliard WS, Diamond I (2004) Recent advances in the neurobiology of alcoholism: the role of adenosine. Pharmacol Ther 101:39-46. CrossRef Medline
    • (2004) Pharmacol Ther , vol.101 , pp. 39-46
    • Mailliard, W.S.1    Diamond, I.2
  • 28
    • 0034175488 scopus 로고    scopus 로고
    • Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation
    • Medline
    • Manabe T, Aiba A, Yamada A, Ichise T, Sakagami H, Kondo H, Katsuki M (2000) Regulation of long-term potentiation by H-Ras through NMDA receptor phosphorylation. J Neurosci 20:2504-2511. Medline
    • (2000) J Neurosci , vol.20 , pp. 2504-2511
    • Manabe, T.1    Aiba, A.2    Yamada, A.3    Ichise, T.4    Sakagami, H.5    Kondo, H.6    Katsuki, M.7
  • 29
    • 0033601374 scopus 로고    scopus 로고
    • Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors
    • CrossRef Medline
    • Mattingly RR (1999) Phosphorylation of serine 916 of Ras-GRF1 contributes to the activation of exchange factor activity by muscarinic receptors. J Biol Chem 274:37379-37384. CrossRef Medline
    • (1999) J Biol Chem , vol.274 , pp. 37379-37384
    • Mattingly, R.R.1
  • 31
    • 0027337519 scopus 로고
    • Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase
    • CrossRef Medline
    • Moodie SA, Willumsen BM, Weber MJ, Wolfman A (1993) Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 260:1658-1661. CrossRef Medline
    • (1993) Science , vol.260 , pp. 1658-1661
    • Moodie, S.A.1    Willumsen, B.M.2    Weber, M.J.3    Wolfman, A.4
  • 32
    • 49649099238 scopus 로고    scopus 로고
    • N-Ras or K-Ras inhibition increases the number and enhances the function ofFoxp3 regulatory Tcells
    • CrossRef Medline
    • Mor A, Keren G, Kloog Y, George J (2008) N-Ras or K-Ras inhibition increases the number and enhances the function ofFoxp3 regulatory Tcells. Eur J Immunol 38:1493-1502. CrossRef Medline
    • (2008) Eur J Immunol , vol.38 , pp. 1493-1502
    • Mor, A.1    Keren, G.2    Kloog, Y.3    George, J.4
  • 34
    • 78650582052 scopus 로고    scopus 로고
    • Role for mammalian targetof rapamycin complex 1signalingin neuroadaptations underlying alcohol-related disorders
    • CrossRef Medline
    • Neasta J, Ben Hamida S, Yowell Q, Carnicella S, Ron D (2010) Role for mammalian targetof rapamycin complex 1signalingin neuroadaptations underlying alcohol-related disorders. Proc Natl Acad Sci U S A 107: 20093-20098. CrossRef Medline
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 20093-20098
    • Neasta, J.1    Ben Hamida, S.2    Yowell, Q.3    Carnicella, S.4    Ron, D.5
  • 35
    • 79958024816 scopus 로고    scopus 로고
    • AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors
    • CrossRef Medline
    • Neasta J, Ben Hamida S, Yowell QV, Carnicella S, Ron D (2011) AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. Biol Psychiatry 70:575-582. CrossRef Medline
    • (2011) Biol Psychiatry , vol.70 , pp. 575-582
    • Neasta, J.1    Ben Hamida, S.2    Yowell, Q.V.3    Carnicella, S.4    Ron, D.5
  • 36
    • 0242722234 scopus 로고    scopus 로고
    • Is the Ras-MAPK signalling pathway necessary for long-term memory formation?
    • CrossRef Medline
    • Orban PC, Chapman PF, Brambilla R (1999) Is the Ras-MAPK signalling pathway necessary for long-term memory formation? Trends Neurosci 22:38-44. CrossRef Medline
    • (1999) Trends Neurosci , vol.22 , pp. 38-44
    • Orban, P.C.1    Chapman, P.F.2    Brambilla, R.3
  • 37
    • 80054827869 scopus 로고    scopus 로고
    • Transcriptional and epigenetic mechanisms of addiction
    • CrossRef Medline
    • Robison AJ, Nestler EJ (2011) Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 12:623-637. CrossRef Medline
    • (2011) Nat Rev Neurosci , vol.12 , pp. 623-637
    • Robison, A.J.1    Nestler, E.J.2
  • 38
    • 84868530358 scopus 로고    scopus 로고
    • Signaling pathways mediating alcohol effects
    • CrossRef Medline
    • Ron D, Messing RO (2013) Signaling pathways mediating alcohol effects. Curr Top Behav Neurosci 13:87-126. CrossRef Medline
    • (2013) Curr Top Behav Neurosci , vol.13 , pp. 87-126
    • Ron, D.1    Messing, R.O.2
  • 40
    • 77953544634 scopus 로고    scopus 로고
    • The addicted synapse: Mechanisms of synaptic and structural plasticity in nucleus accumbens
    • CrossRef Medline
    • Russo SJ, Dietz DM, Dumitriu D, Morrison JH, Malenka RC, Nestler EJ (2010) The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci 33:267-276. CrossRef Medline
    • (2010) Trends Neurosci , vol.33 , pp. 267-276
    • Russo, S.J.1    Dietz, D.M.2    Dumitriu, D.3    Morrison, J.H.4    Malenka, R.C.5    Nestler, E.J.6
  • 41
    • 0034722890 scopus 로고    scopus 로고
    • Farnesyltransferase and geranylgeranyl-transferase I inhibitors and cancer therapy: Lessons from mechanism and bench-to-bedside translational studies
    • CrossRef Medline
    • Sebti SM, Hamilton AD (2000) Farnesyltransferase and geranylgeranyl-transferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies. Oncogene 19:6584-6593. CrossRef Medline
    • (2000) Oncogene , vol.19 , pp. 6584-6593
    • Sebti, S.M.1    Hamilton, A.D.2
  • 43
    • 84860465524 scopus 로고    scopus 로고
    • The neurobiology ofbinge-like ethanol drinking: Evidence from rodent models
    • CrossRef Medline
    • Sprow GM, Thiele TE (2012) The neurobiology ofbinge-like ethanol drinking: evidence from rodent models. Physiol Behav 106:325-331. CrossRef Medline
    • (2012) Physiol Behav , vol.106 , pp. 325-331
    • Sprow, G.M.1    Thiele, T.E.2
  • 44
    • 0035135929 scopus 로고    scopus 로고
    • Small GTP-binding proteins
    • Medline
    • Takai Y, Sasaki T, Matozaki T (2001) Small GTP-binding proteins. Physiol Rev 81:153-208. Medline
    • (2001) Physiol Rev , vol.81 , pp. 153-208
    • Takai, Y.1    Sasaki, T.2    Matozaki, T.3
  • 45
    • 0038267569 scopus 로고    scopus 로고
    • H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity
    • CrossRef Medline
    • Thornton C, Yaka R, Dinh S, Ron D (2003) H-Ras modulates N-methyl-D-aspartate receptor function via inhibition of Src tyrosine kinase activity. J Biol Chem 278:23823-23829. CrossRef Medline
    • (2003) J Biol Chem , vol.278 , pp. 23823-23829
    • Thornton, C.1    Yaka, R.2    Dinh, S.3    Ron, D.4
  • 47
    • 77950839936 scopus 로고    scopus 로고
    • Spatially restricting gene expression by local translation at synapses
    • CrossRef Medline
    • Wang DO, Martin KC, Zukin RS (2010) Spatially restricting gene expression by local translation at synapses. Trends Neurosci 33:173-182. CrossRef Medline
    • (2010) Trends Neurosci , vol.33 , pp. 173-182
    • Wang, D.O.1    Martin, K.C.2    Zukin, R.S.3
  • 48
    • 0037631371 scopus 로고    scopus 로고
    • Phos-phorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex
    • CrossRef Medline
    • Yang H, Cooley D, Legakis JE, Ge Q, Andrade R, Mattingly RR (2003) Phos-phorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex. J Biol Chem 278: 13278-13285. CrossRef Medline
    • (2003) J Biol Chem , vol.278 , pp. 13278-13285
    • Yang, H.1    Cooley, D.2    Legakis, J.E.3    Ge, Q.4    Andrade, R.5    Mattingly, R.R.6
  • 49
    • 78049309392 scopus 로고    scopus 로고
    • Small G protein signaling in neuronal plasticity and memory formation: The specific role of ras family proteins
    • CrossRef Medline
    • Ye X, Carew TJ (2010) Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins. Neuron 68: 340-361. CrossRef Medline
    • (2010) Neuron , vol.68 , pp. 340-361
    • Ye, X.1    Carew, T.J.2
  • 50
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • CrossRef Medline
    • Zhang FL, Casey PJ (1996) Protein prenylation: molecular mechanisms and functional consequences. Annu Rev Biochem 65:241-269. CrossRef Medline
    • (1996) Annu Rev Biochem , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2


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