Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents

PLoS ONE

Volumn 3, Issue 3, 2008, Pages

  Desrivières, Sylvane ^a   Krause, Kristina ^a,b   Dyer, Anne ^b   Frank, Josef ^b   Blomeyer, Dorothea ^b   Lathrop, Mark ^c   Mann, Karl ^b   Banaschewski, Tobias ^b   Laucht, Manfred ^b,d   Schumann, Gunter ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c CENTRE NATIONAL DE GÉNOTYPAGE   (France)

^d UNIVERSITY OF POTSDAM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85;

3' UNTRANSLATED REGION; ADOLESCENT; ARTICLE; CHILD BEHAVIOR; DRINKING BEHAVIOR; DRUNKENNESS; EXON; FAMILY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MALE; NUCLEOTIDE SEQUENCE; PARENT; PREVALENCE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; GENETICS; LONGITUDINAL STUDY; PROMOTER REGION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADOLESCENT; ADOLESCENT BEHAVIOR; ALCOHOL DRINKING; ALLELES; GENE FREQUENCY; HAPLOTYPES; HUMANS; LONGITUDINAL STUDIES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS);

EID: 46349083912     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0001769     Document Type: Article

References (50)

1. McCarty CA, Ebel BE, Garrison MM, DiGiuseppe DL, Christakis DA, et al. (2004) Continuity of binge and harmful drinking from late adolescence to early adulthood. Pediatrics 114: 714-719.
2. Tyndale RF (2003) Genetics of alcohol and tobacco use in humans. Ann Med 35: 94-121.
3. Crabbe JC (2002) Genetic contributions to addiction. Annu Rev Psychol 53: 435-462.
4. Higuchi S, Matsushita S, Kashima H (2006) New findings on the genetic influences on alcohol use and dependence. Curr Opin Psychiatry 19: 253-265.
5. Uhl GR, Drgon T, Johnson C, Fatusin OO, Liu QR, et al. (2008) "Higher order" addiction molecular genetics: Convergent data from genome-wide association in humans and mice. Biochem Pharmacol 75: 98-111.
6. Tsai G, Coyle JT (1998) The role of glutamatergic neurotransmission in the pathophysiology of alcoholism. Annu Rev Med 49: 173-184.
7. Dodd PR, Beckmann AM, Davidson MS, Wilce PA (2000) Glutamate-mediated transmission, alcohol, and alcoholism. Neurocheom Int 37: 509-533.
8. Backstrom P, Bachteler D, Koch S, Hyytia P, Spanagel R (2004) mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29: 921-928.
9. Schroeder JP, Overstreet DH, Hodge CW (2005) The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology (Berl) 179: 262-270.
10. Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, et al. (2005) the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Mol Pharmacol 67: 349-355.
11. Cowen MS, Djouma E, Lawrence AJ (2005) The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J Pharmacol Exp net 315: 590-600.
12. Hodge CW, Miles MF, Sharko AC, Stevenson RA, Hillmann JR, et al. (2006) The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology (Berl) 183: 429-438.
13. Daw MI, Bortolotto ZA, Saulle E, Zaman S, Collingridge GL, et al. (2002) Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression. Nat Neurosci 5: 835-836.
14. Perkinton MS, Ip JK, Wood GL, Crossthwaite AJ, Williams RJ (2002) Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurrones. J Neurochem 80: 239-254.
15. Man HY, Wang Q, Lu WY, Ju W, Ahmadian G, et al. (2003) Activation of PI3-kinase is required for AMPA receptor insertion during LIT of mEPSCs in cultured hippocampal neurons. Neuron 38: 611-624.
16. Hou L, Klann E (2004) Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression J Neurosci 24: 6352-6361.
17. Gong R, Park CS, Abbassi NR, Tang SJ (2006) Roles of glutamate receptors and the mammalian target of rapamycin (mTOR) signaling pathway in activity-dependent dendritic protein synthesis in hippocampal neurons. J Biol Chem 281: 18802-18815.
18. Izzo E, Martin-Fardon R, Koob GF, Weiss F, Sanna PP (2002) Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nat Neurosci 5: 1263-1264.
19. Corl AB, Rodan AR, Heberlein U (2005) Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci 8: 18-19.
20. Laucht M, Esser G, Baving L, Gerhold M, Hoesch I, et al. (2000) Behavioral sequelae of perinatal insults and early family adversity at 8 years of age. J Am Acad Child Adolesc Psychiatry 39: 1229-1237.
21. Müller R, Abbet JP (1991) [Changing trends in the consumption of legal and illegal drugs by 11-16-year-old adolescent pupils. Findings from a study conducted under the auspices of the WHO Europe]. Lausanne: Swiss Professional Service for Alcohol Problems.
22. Skinner HA, Shen WJ (1982) Reliability of alcohol use indices. The Lifetime Drinking History and the MAST. J Stud Alcohol 43: 1157-1170.
23. Dudbridge F (2003) Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25: 115-121.
24. Siepel A, Bejerano G, Pedersen JS, Hinrichs AS, Hou M, et al. (2005) Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res 15: 1034-1050.
25. Davuluri RV, Grosse I, Zhang MQ (2001) Computational identification of promoters and first exons in the human genome. Nat Genet 29: 412-417.
26. Long F, Liu H, Hahn C, Sumazin P, Zhang MQ et al. (2004) Genome-wide prediction and analysis of function-specific transcription factor binding sites. In Silico Biol 4: 395-410.
27. Sandelin A, Wasserman WW, Lenhard B (2004) ConSite: web-based prediction of regulatory elements using cross-species comparison. Nucleic Acids Res 32: W249-252.
28. Massari ME, Murre C (2000) Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol 20: 429-440.
29. Pincock S (2003) Binge drinking on rise in UK and elsewhere. Government report shows increases in alcohol consumption, cirrhosis, and premature deaths. Lancet 362: 1126-1127.
30. Bonomo YA, Bowes G, Coffey C, Carlin JB, Patton GC (2004) Teenage drinking and the onset of alcohol dependence: a cohort study over seven years. Addiction 99: 1520-1528.
31. Grant BF, Dawson DA (1997) Age at onset ofalcohol use and its association with DSM-IV alcohol abuse and dependence: results from the National Longitudinal Alcohol Epidemiologic Survey. J Subst Abuse 9: 103-110.
32. DeWit DJ, Adlaf EM, Offord DR, Ogborne AC (2000) Age at first alcohol use: a risk factor for the development of alcohol disorders. Am J Psychiatry 157: 745-750.
33. Hingson R, Heeren T, Zakocs R, Winter M, Wechsler H (2003) Age of first intoxication, heavy drinking, driving after drinking and risk of unintentional injury among U.S. college students. J Stud Alcohol 64: 23-31.
34. Nolen-Hoeksema S, Hilt L (2006) Possible contributors to the gender differences in alcohol use and problems. J Gen Psycbol 133: 357-374.
35. Sun M, Yang L, Feldman RI, Sun XM, Bhalla KN, et al. (2003) Activation of phosphatidylinositol 3-kinase/Akt pathway by androgen through interaction of p85alpha, androgen receptor, and Src. J Biol Chem 278: 42992-43000.
36. Simoncini T, Hafezi-Moghadam A, Brazil DP, Ley K, Chin WW, et al. (2000) Interaction of oestrogen receptor with the regulatory subunit of phosphatidy-linositol-3-OH kinase. Nature 407: 538-541.
37. Hyman SE, Malenka RC, Nestler EJ (2006) Neunal mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci 29: 565-598.
38. Yang F, He X, Feng L, Mizuno K, Liu XW, et al. (2001) PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation. Nat Neurosci 4: 19-28.
39. Kelly A, Lynch MA (2000) Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin. Neuropharmacology 39: 643-651.
40. Huang CC, Lee CC, Hsu KS (2004) An investigation into signal transduction mechanisms involved in insidin-induced long-term depression in the CAI region of the hippocampus. J Neurochem 89: 217-231.
41. Sanna PP, Cammalleri M, Berton F, Simpson C, Lutjens R, et al. (2002) Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CAI region. J Neurosci 22: 3359-3365.
42. Xu K, Anderson TR, Neyer KM, Lamparella N, Jenkins G, et al. (2007) Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. Pharmacogenomics J.
43. Urbanek P, Wang ZQ, Fetka I, Wagner EF, Busslinger M (1994) Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP. Cell 79: 901-912.
44. Sheng HZ, Zhadanov AB, Mosinger B Jr, Fujii T, Bertuzzi S, et al. (1996) Specification of pituitary cell lineages by the LIM homeobox gene Lhx3. Science 272: 1004-1007.
45. Sharma K, Sheng HZ, Lettieri K, Li H, Karavanov A, et al. (1998) LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell 95: 817-828.
46. MacKenzie A, Quinn J (1999) A scrotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proc Natl Acad Sci U S A 96: 15251-15255.
47. Fiskerstrand CE, Lovejoy EA, Quinn JP (1999) An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett 458: 171-174.
48. Pagani F, Baralle FE (2004) Genomic variants in exons and introns: identifying the splicing spoilers. Nat Rev Genet 5: 389-396.
49. Mattick JS, Makunin IV (2006) Non-coding RNA. Hum Mol Genet 15 Spec No 1: R17-29.
50. Sher KJ, Grekin ER, Williams NA (2005) The development of alcohol use disorders. Annu Rev Clin Psychol 1: 493-523.