Probing the effect of drug loading and humidity on the mechanical properties of solid dispersions with nanoindentation: Antiplasticization of a polymer by a drug molecule

Molecular Pharmaceutics

Volumn 9, Issue 11, 2012, Pages 3396-3402

  Lamm, Matthew S ^a   Simpson, Amanda ^b   McNevin, Michael ^a   Frankenfeld, Celeste ^a   Nay, Richard ^b   Variankaval, Narayan ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Bruker Corporation   (United States)

Author keywords

amorphous solid dispersions; antiplasticization; clotrimazole; copovidone; nanoindentation

Indexed keywords

CLOTRIMAZOLE; KOLLIDON VA64; POLYMER; UNCLASSIFIED DRUG; VINYL ACETATE;

ARTICLE; CONCENTRATION (PARAMETERS); DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG SYNTHESIS; FILM; GLASS TRANSITION TEMPERATURE; HARDNESS; HUMIDITY; MOISTURE; PRIORITY JOURNAL; WATER VAPOR; WEIGHT; WETTABILITY; YOUNG MODULUS;

CALORIMETRY, DIFFERENTIAL SCANNING; CLOTRIMAZOLE; DRUG STABILITY; HUMIDITY; MOLECULAR STRUCTURE; POVIDONE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; WETTABILITY;

EID: 84868553255     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp3003013     Document Type: Article

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