Influence of mechanical properties on impact fracture: Prediction of the milling behaviour of pharmaceutical powders by nanoindentation

Powder Technology

Volumn 188, Issue 3, 2009, Pages 301-313

  Meier, M ^a   John, E ^b   Wieckhusen, D ^b   Wirth, W ^b   Peukert, W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Breakage probability; Comminution; Grinding; Material properties; Nanoindentation; Single particle tests

Indexed keywords

CRYSTALLOGRAPHY; CRYSTALS; FORECASTING; FRACTURE MECHANICS; FRACTURE TOUGHNESS; GRINDING (COMMINUTION); GRINDING (MACHINING); HARDNESS; MECHANICAL PROPERTIES; MILLING (MACHINING); NANOINDENTATION; POWDERS; PROBABILITY; PROBABILITY DENSITY FUNCTION; TOUGHNESS;

BREAKAGE FUNCTIONS; BREAKAGE PARAMETERS; BREAKAGE PROBABILITY; BRITTLENESS INDICES; GRINDING; IMPACT FRACTURES; IMPACT GRINDING; INTRINSIC MATERIAL PROPERTIES; MATERIAL PROPERTIES; MILLING PROCESSES; MILLING TESTS; PHARMACEUTICAL POWDERS; SELECTION FUNCTIONS; SINGLE PARTICLE TESTS; SINGLE PARTICLES; YOUNG'S MODULUS;

FRACTURE;

ARTICLE; GRINDING; MECHANICAL STRESS; MOLECULAR DYNAMICS; PARAMETER; PHYSICAL CHEMISTRY; POWDER; YOUNG MODULUS;

EID: 56949083210     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2008.05.009     Document Type: Article

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