Effect of annurca apple polyphenols on human HaCaT keratinocytes proliferation

Journal of Medicinal Food

Volumn 15, Issue 11, 2012, Pages 1024-1031

  D'Angelo, Stefania ^a,b   La Porta, Raffaele ^b   Napolitano, Maria ^c   Galletti, Patrizia ^b   Quagliuolo, Lucio ^b   Boccellino, Mariarosaria ^b  

^a UNIVERSITY OF NAPLES PARTHENOPE   (Italy)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Annurca apple; apoptosis; HaCaT cells; polyphenols; proliferation

Indexed keywords

ANNURCA APPLE POLYPHENOL EXTRACT; PLANT MEDICINAL PRODUCT; POLYPHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANNURCA; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; APPLE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL;

APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE; CELL PROLIFERATION; CHLOROGENIC ACID; FLAVONOIDS; FRUIT; HUMANS; KERATINOCYTES; MALUS; PLANT EXTRACTS; POLYPHENOLS; TANNINS; TUMOR SUPPRESSOR PROTEIN P53;

MALUS X DOMESTICA;

EID: 84868544970     PISSN: 1096620X     EISSN: 15577600     Source Type: Journal    
DOI: 10.1089/jmf.2012.0076     Document Type: Article

References (41)

1. Bravo L: Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998;56:317-333.
2. Manach C, Scalbert A, Morand C, Remesy C, Jimenez L: Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004;79:727-747.
3. Rice-Evans CA, Miller NJ, Bolwell PG, Bramley PM, Pridham JB: The relative antioxidant activities of plant-derived polyphe-nolic flavonoids. Free Radic Res 1995;22:375-383.
4. Liu M, Li XQ, Weber C, Lee CY, Brown J, Liu RH: Antioxidant and antiproliferative activities of raspberries. J Agric Food Chem 2002;50:2926-2930.
5. Giovannini C, Scazzocchio B, Var̀i R, Santangelo C, D'Archivio M, Masella R: Apoptosis in cancer and atherosclerosis: polyphenol activities. Ann Ist Super Sanità 2007;43:406-416.
6. D'Angelo S, Cimmino A, Raimo M, Salvatore A, Zappia V, Galletti P: Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. 'Annurca' apple fruits. J Agric Food Chem 2007;55:9977-9985.
7. Lee KW, Kim YJ, Kim DO, Lee HJ, Lee CY: Major phenolics in apple and their contribution to the total antioxidant capacity. J Agric Food Chem 2003;51:6516-6520.
8. Bitsch R, Netzel M, Carlè E, Strass G: Bioavailability of anti-oxidantive compounds from Brettacher apple juice in humans. Innov Food Sci Emerg Technol 2000;1:245-249.
9. Nelson JAS, Falk RE: The efficacy of phloridzin on the cell growth. Anticancer Res 1993;13:2287-2292.
10. Person DA, Tan CH, German JB, Davis PA, Gershwin MEL: Apple juice inhibits human low density lipoprotein oxidation. Life Sci 1999;64:1913-1920.
11. Eberhardt MV, Lee CY, Liu RH: Antioxidant activity of fresh apples. Nature 2000;405:903-904.
12. Tse WP, Cheng CHK, Che CT, Zhao M, Lin ZX: Induction of apoptosis underlies the Radix Rubiae-mediated antiproliferative action on human epidermal keratinocytes: implications for psoriasis treatment. Inter J Mol Med 2007;20:663-672.
13. Ahmad N, Mukhtar H: Cytochrome p450: a target for drug development for skin diseases. J Invest Dermatol 2004;123:417-425.
14. Lebwohl M: Psoriasis. Lancet 2003;361:1197-1204.
15. Nickoloff BJ, Nestle FO: Recent insights into the im-munopathogenesis of psoriasis provide new therapeutic opportunities. J Clin Invest 2004;113:1664-1675.
16. Schwartz PM, Barnett SK, Atillasoy ES, Milstone LM: Metho-trexate induces differentiation of human keratinocytes. Proc Natl Acad Sci USA 1992;89:594-598.
17. Pol A, Bergers M, Schalkwijk J: Comparison of antiproliferative effects of experimental and established antipsoriatic drugs on human keratinocytes, using a simple 96-wellplate assay. In Vitro Cell Dev Biol Anim 2003;39:36-42.
18. Takahashi H, Ibe M, Kinouchi M, Ishida-Yamamoto A, Hashimoto Y, Iizuka H: Similarly potent action of 1, 25-dihy-droxyvitamin D3 and its analogues, tacalcitol, calcipotriol, and maxacalcitol on normal human keratinocyte proliferation and differentiation. J Dermatol Sci 2003;31:21-28.
19. Koo J, Arain S: Traditional Chinese medicine for the treatment of dermatologic disorders. Arch Dermatol 1998;134:1388-1393.
20. Tse TW: Use of common Chinese herbs in the treatment of psoriasis. Clin Exp Dermatol 2003;28:469-475.
21. Navarro-Perán E, Cabezas-Herrera J, Garćia-Cánovas F, Durrant MC, Thorneley RN, Rodŕiguez-López JN: The antifolate activity of tea catechins. Cancer Res 2005;65:2059-2064.
22. Hsu S, Dickinson D, Borke J, et al.: Green tea polyphenol induces caspase 14 in epidermal keratinocytes via MAPK pathways and reduces psoriasiform lesions in the flaky skin mouse model. Exp Dermatol 2007;16:678-684.
23. Singleton VL, Orthofer R, Lamuela-Raventos RM: Analysisoftotal phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 1999;299:152-178.
24. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE: Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988;106:761-771.
25. Garach-Jehoshua O, Ravid A, Liberman UA, Koren R:1, 25-Dihydroxyvitamin D3 increases the growth-promoting activity of autocrine epidermal growth factor receptor ligands in keratino-cytes. Endocrinology 1999;140:713-721.
26. Farkas A, Kemény L, et al.: Dithranol upregulates IL-10 receptors on the cultured human keratinocyte cell line HaCaT. Inflamm Res 2001;50:44-49.
27. Thielitz A, Bukowska A, Wolke C, et al.: Identification of extraand intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation. Biochem Biophys Res Commun 2004;321:795-801.
28. Bernhard D, Schwaiger W, Crazzolara R, Tinhofer I, Kofler R, Csordas A: Enhanced MTT-reducing activity under growth inhibition by resveratrol in CEM-C7H2 lymphocytic leukaemia cells. Cancer Lett 2003;195:193-199.
29. McGahon AJ, Martin SJ, Bissonnette RP, et al.: The end of the (cell) line: methods for the study of apoptosis in vitro. Methods Cell Biol 1995;46:153-185.
30. Tse WP, Che CT, Lin ZX: Evaluation of the anti-proliferative properties of selected psoriasis-treating Chinese medicines on cultured HaCaT cells. J Ethnopharmacol 2006;10:8133-8141.
31. Galati G, O'Brien PJ: Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 2004;37:287-303.
32. Vousden KH, Lane DP: p53 in health and disease. Nat Rev Mol Cell Biol 2007;8:275-283.
33. Ko LJ, Prives C: p53: puzzle and paradigm. Genes Dev 1996;10:1054-1072.
34. Vogelstein B, Lane D, Levine AJ: Surfing the p53 network. Nature 2000;40:8307-8310.
35. Wang P, Song JH, Song DK, Zhang J, Hao C: Role of death receptor and mitochondrial pathways in conventional chemotherapy drug induction of apoptosis. Cell Signal 2006;18:1528-1535.
36. Fadeel B, Ottosson A, Pervaiz S: Big wheel keeps on turning: apoptosome regulation and its role in chemoresistance. Cell Death Differ 2008;15:443-452.
37. Kern M, Pahlke G, Balavenkatraman KK, Bohmer FD, Marko D: Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. J Agric Food Chem 2007;55:4999-5006.
38. Krüger-Krasagakis S, Galanopoulos VK, Giannikaki L, Stefanidou M, Tosca AD: Programmed celldeathofkeratinocytesininfliximab-treated plaque-type psoriasis. Br J Dermatol 2006;154:460-466.
39. Wrone-Smith T, Johnson T, Nelson B, et al.: Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psori-atic keratinocytes in vivo. Am J Pathol 1995;146:1079-1088.
40. Wrone-Smith T, Mitra RS, Thompson CB, Jasty R, Castle VP, Nickoloff BJ: Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin. Am J Pathol 1997;151:1321-1329.
41. Takahashi H, Manabe A, Ishida-Yamamoto A, Hashimoto Y, Iizuka H: Aberrant expression of apoptosis-related molecules in psoriatic epidermis. J Dermatol Sci 2002;28:187-197.