Molecular alterations as target for therapy in metastatic osteosarcoma: A review of literature

Clinical and Experimental Metastasis

Volumn 28, Issue 5, 2011, Pages 493-503

  Posthumadeboer, J ^a   Witlox, M A ^b   Kaspers, G J L ^a   Van Royen, B J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Westfries Gasthuis ^*  (Netherlands)

Author keywords

Drug resistance; Metastasis; Osteosarcoma; Therapy

Indexed keywords

ALPHA INTERFERON; ANTINEOPLASTIC AGENT; BETA CATENIN; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; DASATINIB; ENDOSTATIN; EZRIN; FAS ANTIGEN; FOCAL ADHESION KINASE; GEMCITABINE; IFOSFAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 18; MURAMYL TRIPEPTIDE; MURAMYL TRIPEPTIDE PHOSPHATIDYLETHANOLAMINE; OCTREOTIDE; PHOSPHATIDYLETHANOLAMINE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN TYROSINE KINASE; R 1507; ROBATUMUMAB; SARACATINIB; SOMATOMEDIN C RECEPTOR; SORAFENIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN;

ANGIOGENESIS; ANOIKIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER RESISTANCE; CANCER THERAPY; CELL ADHESION; CELL CYCLE ARREST; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL TRIAL (TOPIC); DRUG TARGETING; HUMAN; IMMUNE SYSTEM; LUNG METASTASIS; METASTASIS; OSTEOSARCOMA; OSTEOSARCOMA CELL; OSTEOSARCOMA; PHOSPHATIDYLETHANOLAMINE; REVIEW;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE NEOPLASMS; HUMANS; MOLECULAR TARGETED THERAPY; NEOPLASM METASTASIS; OSTEOSARCOMA;

EID: 79955524738     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-011-9384-x     Document Type: Review

References (84)

1. L Mirabello RJ Troisi SA Savage 2009 Osteosarcoma incidence and survival rates from 1973 to 2004: data from the Surveillance, Epidemiology, and End Results Program Cancer 115 7 1531 1543 19197972
2. G Bacci M Rocca M Salone, et al. 2008 High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions J Surg Oncol 98 6 415 420 18792969
3. SS Bielack D Carrle J Hardes, et al. 2008 Bone tumors in adolescents and young adults Curr Treat Options Oncol 9 1 67 80 18449804
4. MT Harting ML Blakely 2006 Management of osteosarcoma pulmonary metastases Semin Pediatr Surg 15 1 25 29 16458843 (Pubitemid 43177159)
5. DP Hughes 2009 Strategies for the targeted delivery of therapeutics for osteosarcoma Expert Opin Drug Deliv 6 12 1311 1321 19761419 1:CAS:528: DC%2BD1MXhs1aqtLfP
6. PJ Messerschmitt RM Garcia FW bdul-Karim, et al. 2009 Osteosarcoma J Am Acad Orthop Surg 17 8 515 527 19652033
7. L Kager A Zoubek U Potschger, et al. 2003 Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols J Clin Oncol 21 10 2011 2018 12743156 (Pubitemid 46606391)
8. SS Bielack B Kempf-Bielack G Delling, et al. 2002 Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols J Clin Oncol 20 3 776 790 11821461 (Pubitemid 34111386)
9. SA Eccles DR Welch 2007 Metastasis: recent discoveries and novel treatment strategies Lancet 369 9574 1742 1757 17512859 1:CAS:528: DC%2BD2sXlsFertrc%3D (Pubitemid 46755391)
10. E Pradelli B Karimdjee-Soilihi JF Michiels, et al. 2009 Antagonism of chemokine receptor CXCR3 inhibits osteosarcoma metastasis to lungs Int J Cancer 125 11 2586 2594 19544560 1:CAS:528:DC%2BD1MXht1WmsLnL
11. NI Rodriguez WK Hoots NV Koshkina, et al. 2008 COX-2 expression correlates with survival in patients with osteosarcoma lung metastases J Pediatr Hematol Oncol 30 7 507 512 18797196 1:CAS:528:DC%2BD1cXptlGksbs%3D
12. J Fuchs G Seitz V Ellerkamp, et al. 2008 Analysis of sternotomy as treatment option for the resection of bilateral pulmonary metastases in pediatric solid tumors Surg Oncol 17 4 323 330 18586485
13. A Briccoli M Rocca M Salone, et al. 2010 High grade osteosarcoma of the extremities metastatic to the lung: long-term results in 323 patients treated combining surgery and chemotherapy, 1985-2005 Surg Oncol 19 4 193 199 19515554
14. K Krishnan C Khanna LJ Helman 2005 The biology of metastases in pediatric sarcomas Cancer J 11 4 306 313 16197720 1:CAS:528:DC%2BD2MXhtFegtLvE (Pubitemid 44698797)
15. F deNigris R Rossiello C Schiano, et al. 2008 Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis Cancer Res 68 6 1797 1808 1:CAS:528:DC%2BD1cXjtFOhsLk%3D (Pubitemid 351416565)
16. CM Diaz-Montero JN Wygant BW McIntyre 2006 PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation Eur J Cancer 42 10 1491 1500 16759849 1:CAS:528:DC%2BD28XlvF2jsbs%3D (Pubitemid 43903158)
17. Y Guo EM Rubin J Xie, et al. 2008 Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model Clin Orthop Relat Res 466 9 2039 2045 18566875
18. P Hingorani W Zhang R Gorlick, et al. 2009 Inhibition of Src phosphorylation alters metastatic potential of osteosarcoma in vitro but not in vivo Clin Cancer Res 15 10 3416 3422 19447875 1:CAS:528:DC%2BD1MXmtVKmu7g%3D
19. M Kansara DM Thomas 2007 Molecular pathogenesis of osteosarcoma DNA Cell Biol 26 1 1 18 17263592 1:CAS:528:DC%2BD2sXhtVKkur8%3D (Pubitemid 46219587)
20. M Kansara M Tsang L Kodjabachian, et al. 2009 Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice J Clin Invest 119 4 837 851 19307728 1:CAS:528:DC%2BD1MXktlSntrY%3D
21. C Khanna X Wan S Bose, et al. 2004 The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis Nat Med 10 2 182 186 14704791 1:CAS:528:DC%2BD2cXoslKmsw%3D%3D (Pubitemid 38524889)
22. SY Kim CH Lee BV Midura, et al. 2008 Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases Clin Exp Metastasis 25 3 201 211 18071913 1:CAS:528:DC%2BD1cXnt1ensL0%3D
23. EA Lafleur NV Koshkina J Stewart, et al. 2004 Increased Fas expression reduces the metastatic potential of human osteosarcoma cells Clin Cancer Res 10 23 8114 8119 15585647 1:CAS:528:DC%2BD2cXhtVCrs7vL (Pubitemid 39587553)
24. M Pasello F Michelacci I Scionti, et al. 2008 Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma Cancer Res 68 16 6661 6668 18701490 1:CAS:528:DC%2BD1cXpslKms74%3D
25. L Ren SH Hong J Cassavaugh, et al. 2009 The actin-cytoskeleton linker protein ezrin is regulated during osteosarcoma metastasis by PKC Oncogene 28 6 792 802 19060919 1:CAS:528:DC%2BD1cXhsVKlt7rJ
26. IC Wang YJ Chen DE Hughes, et al. 2008 FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness J Biol Chem 283 30 20770 20778 18524773 1:CAS:528:DC%2BD1cXoslWrsLY%3D
27. C Zucchini A Rocchi MC Manara, et al. 2008 Apoptotic genes as potential markers of metastatic phenotype in human osteosarcoma cell lines Int J Oncol 32 1 17 31 18097539 1:CAS:528:DC%2BD1cXhtVOltb0%3D (Pubitemid 351176058)
28. R Gorlick P Anderson I Andrulis, et al. 2003 Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary Clin Cancer Res 9 15 5442 5453 14654523 (Pubitemid 37499462)
29. T Kawabe 2004 G2 checkpoint abrogators as anticancer drugs Mol Cancer Ther 3 4 513 519 15078995 1:CAS:528:DC%2BD2cXivFygsr0%3D
30. KA Nyberg RJ Michelson CW Putnam, et al. 2002 Toward maintaining the genome: DNA damage and replication checkpoints Annu Rev Genet 36 617 656 12429704 1:CAS:528:DC%2BD3sXjslertA%3D%3D (Pubitemid 36109200)
31. HC Reinhardt AS Aslanian JA Lees, et al. 2007 p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage Cancer Cell 11 2 175 189 17292828 1:CAS:528: DC%2BD2sXitVartLc%3D (Pubitemid 46209849)
32. RG Syljuasen S Jensen J Bartek, et al. 2006 Adaptation to the ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1 kinases Cancer Res 66 21 10253 10257 17079442 1:CAS:528:DC%2BD28XhtFGjsrvP (Pubitemid 44799740)
33. D Hanahan RA Weinberg 2000 The hallmarks of cancer Cell 100 1 57 70 10647931 1:CAS:528:DC%2BD3cXks1CktA%3D%3D (Pubitemid 30046295)
34. T Kashima K Nakamura J Kawaguchi, et al. 2003 Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo Int J Cancer 104 2 147 154 12569568 1:CAS:528:DC%2BD3sXhvFyktrY%3D (Pubitemid 36249788)
35. PS Steeg 2006 Tumor metastasis: mechanistic insights and clinical challenges Nat Med 12 8 895 904 16892035 1:CAS:528:DC%2BD28Xnsl2iu74%3D (Pubitemid 44175140)
36. LL Worth EA Lafleur SF Jia, et al. 2002 Fas expression inversely correlates with metastatic potential in osteosarcoma cells Oncol Rep 9 4 823 827 12066216 1:CAS:528:DC%2BD38XltlGrsrY%3D
37. RO Hynes 2003 Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both? Cell 113 7 821 823 12837240 1:CAS:528:DC%2BD3sXlsVSjtb8%3D (Pubitemid 36792026)
38. C Khanna J Khan P Nguyen, et al. 2001 Metastasis-associated differences in gene expression in a murine model of osteosarcoma Cancer Res 61 9 3750 3759 11325848 1:CAS:528:DC%2BD3MXjsFCgurc%3D (Pubitemid 32694989)
39. AJ Minn GP Gupta PM Siegel, et al. 2005 Genes that mediate breast cancer metastasis to lung Nature 436 7050 518 524 16049480 1:CAS:528: DC%2BD2MXmsFCgs7o%3D (Pubitemid 41112921)
40. P Anderson L Kopp N Anderson, et al. 2008 Novel bone cancer drugs: investigational agents and control paradigms for primary bone sarcomas (Ewing's sarcoma and osteosarcoma) Expert Opin Investig Drugs 17 11 1703 1715 18922107 1:CAS:528:DC%2BD1cXht1CmsbnN
41. DP Hughes 2010 How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize Cancer Treat Res 152 479 496
42. C Laverdiere BH Hoang R Yang, et al. 2005 Messenger RNA expression levels of CXCR4 correlate with metastatic behavior and outcome in patients with osteosarcoma Clin Cancer Res 11 7 2561 2567 15814634 1:CAS:528: DC%2BD2MXivFKisrs%3D (Pubitemid 40569454)
43. DG Fan JY Dai J Tang, et al. 2009 Silencing of calpain expression reduces the metastatic potential of human osteosarcoma cells Cell Biol Int 33 12 1263 1267 19747555 1:CAS:528:DC%2BD1MXhsVGltbbP
44. LC Kim L Song EB Haura 2009 Src kinases as therapeutic targets for cancer Nat Rev Clin Oncol 6 10 587 595 19787002
45. Y Pignochino G Grignani G Cavalloni, et al. 2009 Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways Mol Cancer 8 118 20003259
46. EM Rubin Y Guo K Tu, et al. 2010 Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma Mol Cancer Ther 9 3 731 741 20197388 1:CAS:528:DC%2BC3cXivFensLg%3D
47. Y Guo X Zi Z Koontz, et al. 2007 Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells J Orthop Res 25 7 964 971 17318900 1:CAS:528:DC%2BD2sXotFanur0%3D (Pubitemid 47046444)
48. F Engin T Bertin O Ma, et al. 2009 Notch signaling contributes to the pathogenesis of human osteosarcomas Hum Mol Genet 18 8 1464 1470 19228774 1:CAS:528:DC%2BD1MXktV2hurY%3D
49. M Tanaka T Setoguchi M Hirotsu, et al. 2009 Inhibition of Notch pathway prevents osteosarcoma growth by cell cycle regulation Br J Cancer 100 12 1957 1965 19455146 1:CAS:528:DC%2BD1MXntFygurw%3D
50. P Zhang Y Yang PA Zweidler-McKay, et al. 2008 Critical role of notch signaling in osteosarcoma invasion and metastasis Clin Cancer Res 14 10 2962 2969 18483362 1:CAS:528:DC%2BD1cXmtVCmtLw%3D
51. FH Igney PH Krammer 2002 Death and anti-death: tumour resistance to apoptosis Nat Rev Cancer 2 4 277 288 12001989 1:CAS:528:DC%2BD38XivFGqt7s%3D (Pubitemid 37328781)
52. PC Leow Q Tian ZY Ong Z Yang PL Ee 2010 Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells Invest New Drugs 28 6 766 782 19730790 1:CAS:528:DC%2BC3cXht12qu73M
53. Y Cai AB Mohseny M Karperien, et al. 2010 Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma J Pathol 220 1 24 33 19882675 1:CAS:528:DC%2BC3cXpvFOjug%3D%3D
54. A Jeanes CJ Gottardi AS Yap 2008 Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 27 55 6920 6929 19029934 1:CAS:528:DC%2BD1cXhsVWhu73O
55. N Gordon NV Koshkina SF Jia, et al. 2007 Corruption of the Fas pathway delays the pulmonary clearance of murine osteosarcoma cells, enhances their metastatic potential, and reduces the effect of aerosol gemcitabine Clin Cancer Res 13 15 Pt 1 4503 4510 17671136 1:CAS:528:DC%2BD2sXotlGqtbY%3D (Pubitemid 47219720)
56. X Duan SF Jia N Koshkina, et al. 2006 Intranasal interleukin-12 gene therapy enhanced the activity of ifosfamide against osteosarcoma lung metastases Cancer 106 6 1382 1388 16453328 1:CAS:528:DC%2BD28XjtVCrsbk%3D (Pubitemid 43363918)
57. C Yang S Yang KB Wood, et al. 2009 Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression Apoptosis 14 1 124 133 19052873 1:CAS:528:DC%2BD1cXhsFejtrrP
58. XW Yuan XF Zhu XF Huang, et al. 2007 Interferon-alpha enhances sensitivity of human osteosarcoma U2OS cells to doxorubicin by p53-dependent apoptosis Acta Pharmacol Sin 28 11 1835 1841 17959036 1:CAS:528: DC%2BD2sXhtlGmsLrI
59. BH Hoang T Kubo JH Healey, et al. 2004 Expression of LDL receptor-related protein 5 (LRP5) as a novel marker for disease progression in high-grade osteosarcoma Int J Cancer 109 1 106 111 14735475 1:CAS:528:DC%2BD2cXhs1SmtbY%3D (Pubitemid 38160669)
60. S Schuetze K Wathen E Choy, et al. 2010 Results of a Sarcoma Alliance for Research through Collaboration (SARC) phase II trial of dasatinib in previously treated, high-grade, advanced sarcoma J Clin Oncol 28 15 10009
61. J Whelan D Patterson M Perisoglou, et al. 2010 The role of interferons in the treatment of osteosarcoma Pediatr Blood Cancer 54 3 350 354 19902521
62. EA Lafleur SF Jia LL Worth, et al. 2001 Interleukin (IL)-12 and IL-12 gene transfer up-regulate Fas expression in human osteosarcoma and breast cancer cells Cancer Res 61 10 4066 4071 11358827 1:CAS:528:DC%2BD3MXktVWqtr0%3D (Pubitemid 32720972)
63. Y Nakamura N Yamada H Ohyama, et al. 2006 Effect of interleukin-18 on metastasis of mouse osteosarcoma cells Cancer Immunol Immunother 55 9 1151 1158 16408211 1:CAS:528:DC%2BD28XkvFOju7s%3D (Pubitemid 43800730)
64. AJ Chou ES Kleinerman MD Krailo, et al. 2009 Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children's Oncology Group Cancer 115 22 5339 5348 19637348 1:CAS:528:DC%2BD1MXhsVyqs7bF
65. VO Lewis 2009 What's new in musculoskeletal oncology J Bone Joint Surg Am 91 6 1546 1556 19487537
66. EURAMOS. www.ctu.mrc.ac.uk/euramos. Accessed 18 May 2009. Ref Type: Electronic Citation
67. CY Huang CY Lee MY Chen, et al. 2009 Stromal cell-derived factor-1/CXCR4 enhanced motility of human osteosarcoma cells involves MEK1/2, ERK and NF-kappaB-dependent pathways J Cell Physiol 221 1 204 212 19496172 1:CAS:528:DC%2BD1MXptlOnt78%3D
68. RN Kaplan B Psaila D Lyden 2006 Bone marrow cells in the 'pre-metastatic niche': within bone and beyond Cancer Metastasis Rev 25 4 521 529 17186383 (Pubitemid 46071861)
69. PM Murphy 2001 Chemokines and the molecular basis of cancer metastasis N Engl J Med 345 11 833 835 11556308 1:CAS:528:DC%2BD3MXntFCnsbk%3D
70. X Wan SY Kim LM Guenther, et al. 2009 Beta4 integrin promotes osteosarcoma metastasis and interacts with ezrin Oncogene 28 38 3401 3411 19597468 1:CAS:528:DC%2BD1MXosFWhtr4%3D
71. EI Hauben S Bielack R Grimer, et al. 2006 Clinico-histologic parameters of osteosarcoma patients with late relapse Eur J Cancer 42 4 460 466 16426841 1:STN:280:DC%2BD28%2Fps1ylsg%3D%3D (Pubitemid 43227923)
72. SJ Strauss A McTiernan JS Whelan 2004 Late relapse of osteosarcoma: implications for follow-up and screening Pediatr Blood Cancer 43 6 692 697 15390283 (Pubitemid 39411226)
73. D Barkan JE Green AF Chambers 2010 Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth Eur J Cancer 46 7 1181 1188 20304630 1:CAS:528:DC%2BC3cXkvFKqtr4%3D
74. E Favaro A Amadori S Indraccolo 2008 Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy APMIS 116 7-8 648 659 18834409 1:CAS:528:DC%2BD1cXht1Cjsb%2FL
75. N Almog L Ma R Raychowdhury, et al. 2009 Transcriptional switch of dormant tumors to fast-growing angiogenic phenotype Cancer Res 69 3 836 844 19176381 1:CAS:528:DC%2BD1MXhtFOktrc%3D
76. X Liu M Lei RL Erikson 2006 Normal cells, but not cancer cells, survive severe Plk1 depletion Mol Cell Biol 26 6 2093 2108 16507989 (Pubitemid 43346913)
77. K Scotlandi P Picci H Kovar 2009 Targeted therapies in bone sarcomas Curr Cancer Drug Targets 9 7 843 853 20025572 1:CAS:528:DC%2BD1MXhsFGqtLrF
78. PJ Mansky DJ Liewehr SM Steinberg, et al. 2002 Treatment of metastatic osteosarcoma with the somatostatin analog OncoLar: significant reduction of insulin-like growth factor-1 serum levels J Pediatr Hematol Oncol 24 6 440 446 12218590
79. EA Kolb R Gorlick PJ Houghton, et al. 2008 Initial testing (stage 1) of a monoclonal antibody (SCH 717454) against the IGF-1 receptor by the pediatric preclinical testing program Pediatr Blood Cancer 50 6 1190 1197 18260118 (Pubitemid 351555543)
80. A Abdeen AJ Chou JH Healey, et al. 2009 Correlation between clinical outcome and growth factor pathway expression in osteogenic sarcoma Cancer 115 22 5243 5250 19670450
81. HS Kim SJ Lim YK Park 2009 Anti-angiogenic factor endostatin in osteosarcoma APMIS 117 10 716 723 19775339
82. K Ryu E Choy C Yang M Susa FJ Hornicek H Mankin Z Duan 2010 Activation of signal transducer and activator of transcription 3 (Stat3) pathway in osteosarcoma cells and overexpression of phosphorylated-Stat3 correlates with poor prognosis J Orthop Res 28 7 971 978 20063378 1:CAS:528:DC%2BC3cXosFelsrc%3D
83. M Kaya T Wada S Nagoya, et al. 2007 Prevention of postoperative progression of pulmonary metastases in osteosarcoma by antiangiogenic therapy using endostatin J Orthop Sci 12 6 562 567 18040639 (Pubitemid 350190510)
84. EA Kolb D Kamara W Zhang, et al. 2010 R1507, a fully human monoclonal antibody targeting IGF-1R, is effective alone and in combination with rapamycin in inhibiting growth of osteosarcoma xenografts Pediatr Blood Cancer 55 1 67 75 20486173